MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Hugo	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 168 to 217 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Interaction Map	red	green	network_comparison
42	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Subtracted	Low confidence	242.742	217.217	25.525
43	no value	jun dimerization protein. [refseq;acc:nm_130469]	Divided	High confidence	204.641	160.957	1.2714
	KHDRBS3	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	Subtracted		332.874	267.246	65.628
	MFAP4	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]		Low confidence	242.742	217.217	25.525
	RGS12	regulator of g-protein signaling 12 (rgs12). [swissprot;acc:o14924]	Divided		247.768	219.841	1.12703
44	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]		High confidence	204.641	161.046	1.2707
	KHDRBS1	kh domain containing, rna binding, signal transduction associated 1; gap-associated tyrosine phosphoprotein p62 (sam68). [refseq;acc:nm_006559]	Subtracted		332.874	267.246	65.628
	PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	Divided	Low confidence	242.742	217.217	1.11751
	PPP1R14D	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Subtracted				25.525
45	FCN2	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Divided	High confidence	204.641	161.051	1.27066
	KHDRBS2	kh domain-containing, rna-binding, signal transduction-associated protein 2; sam68-like mammalian protein 1. [refseq;acc:nm_152688]	Subtracted		332.874	267.246	65.628
	MFAP4	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	Low confidence	242.742	217.217	1.11751
46	no value	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Subtracted				25.525
	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Divided	High confidence	204.642	161.068	1.27053
	NEURL	neuralized-like. [refseq;acc:nm_004210]	Subtracted		332.326	266.948	65.378
	PPP1R14D	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Divided	Low confidence	242.742	217.217	1.11751
47	FCN2	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]
	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted		259.517	235.017	24.5
	TMEM132A	gbp protein isoform a. [refseq;acc:nm_017870]	Divided	High confidence	325.586	256.492	1.26938
	TOB2	tob2 protein (transducer of erbb-2 2). [swissprot;acc:q14106]	Subtracted		350	290	60
48	no value	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Divided	Low confidence	242.742	217.217	1.11751
	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]		High confidence	65.4586	83.0461	1.26868
	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Subtracted	Low confidence	259.517	235.017	24.5
	TOB1	tob1 protein (transducer of erbb-2 1). [swissprot;acc:p50616]		High confidence	350	290	60
49	ARRB2	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	Divided		133	105	1.26667
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Subtracted		350	290	60
	TBX19	t-box transcription factor tbx19 (t-box protein 19). [swissprot;acc:o60806]	Divided	Low confidence	225.438	202.569	1.11289
			Subtracted				22.869
50	ARRB1	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]	Divided	High confidence	133	105	1.26667
	CPEB4	cytoplasmic polyadenylation element binding protein 4. [refseq;acc:nm_030627]	Subtracted		350	290	60
	JPH3	junctophilin 3 (junctophilin type 3) (jp-3). [swissprot;acc:q8wxh2]	Divided	Low confidence	234.802	260.98	1.11149
	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]	Subtracted		233.134	210.267	22.867
51	CPEB3	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]		High confidence	350	290	60
	GBAS	nipsnap2 protein (glioblastoma amplified sequence). [swissprot;acc:o75323]		Low confidence	249.709	226.944	22.765
	JPH2	junctophilin 2 (junctophilin type 2) (jp-2). [swissprot;acc:q9br39]	Divided		234.802	260.98	1.11149
	SPATA6	spermatogenesis associated 6. [refseq;acc:nm_019073]		High confidence	133	105	1.26667
52	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]
	NIPSNAP1	nipsnap1 protein. [swissprot;acc:q9bpw8]	Subtracted	Low confidence	249.584	226.86	22.724
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]		High confidence	350	290	60
	SMPD2	sphingomyelin phosphodiesterase 2 (ec 3.1.4.12) (neutral sphingomyelinase) (nsmase) (n-smase) (lyso-platelet activating factor- phospholipase c) (lyso-paf-plc). [swissprot;acc:o60906]	Divided	Low confidence	234.802	260.98	1.11149
53	no value	60s ribosomal protein l37a. [swissprot;acc:p12751]	Subtracted		239.692	217.005	22.687
	JUNB	transcription factor jun-b. [swissprot;acc:p17275]	Divided	High confidence	201.144	158.868	1.26611
	NDUFS4	nadh-ubiquinone oxidoreductase 18 kda subunit, mitochondrial precursor (ec 1.6.5.3) (ec 1.6.99.3) (complex i-18 kda) (ci-18 kda) (complex i- aqdq) (ci-aqdq). [swissprot;acc:o43181]	Subtracted		318.982	259.004	59.978
	TMEM33	db83 protein. [swissprot;acc:p57088]	Divided	Low confidence	234.802	260.98	1.11149
54	CPEB3	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]			267.448	240.822	1.11056
	GBE1	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Subtracted	High confidence	185.678	245.247	59.569
	JUND	transcription factor jun-d. [swissprot;acc:p17535]	Divided		200.941	158.941	1.26425
	T	brachyury protein (t protein). [swissprot;acc:o15178]	Subtracted	Low confidence	224.922	202.592	22.33
55	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]			230.944	209.149	21.795

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.