MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Value Type	Gene	Hugo	Interaction Map	description	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1662 to 1711 of 2060 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
network_comparison  : 0
red  : 0
green  : 0

Rank	Value Type	Hugo	description
3171	Ranked	CCNT2	cyclin t2. [swissprot;acc:o60583]
	Squared
	Rooted
3172	Measured	LIPE	hormone sensitive lipase (ec 3.1.1.-) (hsl). [swissprot;acc:q05469]
	Ranked
	Squared
	Rooted
3173	Measured	PIK3C3	phosphoinositide-3-kinase, class 3; vps34; phosphatidylinositol 3-kinase, class 3. [refseq;acc:nm_002647]
	Ranked
	Squared
	Rooted
3174	Measured	TM9SF3	transmembrane 9 superfamily protein member 3 precursor (sm-11044 binding protein) (ep70-p-iso). [swissprot;acc:q9hd45]
	Ranked
	Squared
	Rooted
3175	Measured	TUBA3D	tubulin alpha-3/alpha-7 chain (alpha-tubulin 3/7). [swissprot;acc:p05214]
	Ranked
	Squared
	Rooted
3176	Measured	SLC25A3	phosphate carrier protein, mitochondrial precursor (ptp). [swissprot;acc:q00325]
	Ranked
	Squared
	Rooted
3177	Measured	LMAN1	ergic-53 protein precursor (er-golgi intermediate compartment 53 kda protein) (lectin, mannose-binding 1) (gp58) (intracellular mannose specific lectin mr60). [swissprot;acc:p49257]
	Ranked
	Squared
	Rooted
3178	Measured	no value	transcription initiation factor iie, beta subunit (tfiie-beta). [swissprot;acc:p29084]
	Ranked
	Squared
	Rooted
3179	Measured	DERL2	carcinoma related gene. [refseq;acc:nm_016041]
	Ranked
	Squared
	Rooted
3180	Measured	HSD17B10	3-hydroxyacyl-coa dehydrogenase type ii (ec 1.1.1.35) (type ii hadh) (endoplasmic reticulum-associated amyloid beta-peptide binding protein) (short-chain type dehydrogenase/reductase xh98g2). [swissprot;acc:q99714]
	Ranked
	Squared
	Rooted
3181	Measured	ALDH3A2	fatty aldehyde dehydrogenase (ec 1.2.1.3) (aldehyde dehydrogenase, microsomal) (aldh class 3). [swissprot;acc:p51648]
	Ranked
	Squared
	Rooted
3182	Measured	TCF3	transcription factor e2-alpha (immunoglobulin enhancer binding factor e12/e47) (transcription factor-3) (tcf-3) (immunoglobulin transcription factor-1) (transcription factor itf-1) (kappa-e2-binding factor). [swissprot;acc:p15923]
	Ranked
	Squared
	Rooted
3183	Measured	CBFB	core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]
	Ranked
	Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.