MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Hugo	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1630 to 1679 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
815	STX1B	syntaxin 1b. [swissprot;acc:q15531]	High confidence	212.386	221.785	1.04425
816	CDC25A	m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304]	Low confidence	207.541	202.25	1.02616
	MRPL28	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	High confidence	212.386	221.785	1.04425
817	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	Low confidence	202.15	197.002	1.02613
	RFXANK	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	High confidence	212.386	221.785	1.04425
818	RGL1	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]		168.592	161.452	1.04422
	SERHL2	serine hydrolase-like protein (ec 3.1.-.-). [swissprot;acc:q9h4i8]	Low confidence	208.488	203.181	1.02612
819	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	POLR2I	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	High confidence	228.563	238.668	1.04421
820	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]	Low confidence	208.488	203.181	1.02612
	MRPS2	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	High confidence	221.716	231.501	1.04413
821	IMP4	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]		221.676	231.453	1.0441
	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	Low confidence	208.488	203.181	1.02612
822	ABLIM1	actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
	EIF3B	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	High confidence	243.067	232.805	1.04408
823	C16orf80	transcription factor iib. [refseq;acc:nm_013242]		206.068	197.471	1.04354
	RRAGC	ras-related gtp binding c; rag c protein. [refseq;acc:nm_022157]	Low confidence	186.275	181.537	1.0261
824	SFRS8	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	High confidence	206.068	197.471	1.04354
	ZNF423	olf-1/ebf associated zinc finger protein; smad- and olf-interacting zinc finger protein. [refseq;acc:nm_015069]	Low confidence	204.922	199.711	1.02609
825	no value	early hematopoietic zinc finger. [refseq;acc:nm_015461]		204.914	199.706	1.02608
	WIPF1	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	High confidence	206.214	197.614	1.04352
826	CTSB	cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	Low confidence	201.026	195.916	1.02608
	HTATIP	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	High confidence	223.186	213.912	1.04335
827	LOH12CR1	loh1cr12. [refseq;acc:nm_058169]		230.087	220.579	1.0431
	SPTLC1	serine palmitoyltransferase 1 (ec 2.3.1.50) (long chain base biosynthesis protein 1) (lcb 1) (serine-palmitoyl-coa transferase 1) (spt 1) (spt1). [swissprot;acc:o15269]	Low confidence	207.116	201.851	1.02608
828	COX4I1	cytochrome c oxidase subunit iv isoform 1, mitochondrial precursor (ec 1.9.3.1) (cox iv-1) (cytochrome c oxidase polypeptide iv). [swissprot;acc:p13073]		204.206	199.02	1.02606
	CSDE1	unr protein. [swissprot;acc:o75534]	High confidence	230.087	220.579	1.0431
829	PAK3	serine/threonine-protein kinase pak 3 (ec 2.7.1.-) (p21-activated kinase 3) (pak-3) (beta-pak) (oligophrenin-3). [swissprot;acc:o75914]	Low confidence	202.608	197.472	1.02601
	SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	High confidence	135.844	130.259	1.04288
830	FTSJ3	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	Low confidence	201.067	195.971	1.026
	PARK2	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	High confidence	231.734	222.222	1.0428
831	no value	hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]
	TMLHE	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	Low confidence	204.064	198.895	1.02599
832	no value	cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]	High confidence	231.734	222.222	1.0428
	GABBR2	gamma-aminobutyric acid type b receptor, subunit 2 precursor (gaba-b receptor 2) (gaba-b-r2) (gb2) (gababr2) (g protein-coupled receptor 51) (gpr 51) (hg20). [swissprot;acc:o75899]	Low confidence	204.064	198.895	1.02599
833	ERAL1	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]
	PSIP1	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	High confidence	231.734	222.222	1.0428
834	RPL8	60s ribosomal protein l8. [swissprot;acc:p25120]
	TYRL	tyrosinase-related gene segment, exon 5 (fragment). [sptrembl;acc:q15677]	Low confidence	206.26	201.038	1.02598
835	HDGF	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	High confidence	231.734	222.222	1.0428
	PAK2	serine/threonine-protein kinase pak 2 (ec 2.7.1.-) (p21-activated kinase 2) (pak-2) (pak65) (gamma-pak) (s6/h4 kinase). [swissprot;acc:q13177]	Low confidence	202.578	197.45	1.02597
836	HDGFL1	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	High confidence	231.734	222.222	1.0428
	RRM1	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Low confidence	202.357	197.234	1.02597
837	no value	dj570f3.6 (novel protein similar to lysophospholipase ii (lypla2)). [sptrembl;acc:q9uge0]		194.47	189.552	1.02595
	DDX6	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	High confidence	231.734	222.222	1.0428
838	GLO1	lactoylglutathione lyase (ec 4.4.1.5) (methylglyoxalase) (aldoketomutase) (glyoxalase i) (glx i) (ketone-aldehyde mutase) (s-d-lactoylglutathione methylglyoxal lyase). [swissprot;acc:q04760]	Low confidence	194.47	189.552	1.02595
	TMEM131	rw1 protein (fragment). [swissprot;acc:q92545]	High confidence	231.734	222.222	1.0428
839	CLEC11A	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]		177.776	170.499	1.04268
	LYPLA1	lysophospholipase i; lysophospholipase 1; lysophospholipid-specific lysophospholipase; acyl-protein thioesterase-1. [refseq;acc:nm_006330]	Low confidence	194.47	189.552	1.02595
840	DR1	tata-binding protein-associated phosphoprotein (down-regulator of transcription 1) (dr1 protein). [swissprot;acc:q01658]		201.924	196.817

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.