MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1630 to 1679 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
815	STX1B	syntaxin 1b. [swissprot;acc:q15531]	Divided	212.386	221.785	1.04425
816	EIF3A	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	Subtracted	246.354	237.223	9.131
	MRPL28	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	Divided	212.386	221.785	1.04425
817	CCT3	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	Subtracted	110.689	101.613	9.076
	RFXANK	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	Divided	212.386	221.785	1.04425
818	no value	60s ribosomal protein l39. [swissprot;acc:p02404]	Subtracted	234.025	224.958	9.067
	RGL1	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Divided	168.592	161.452	1.04422
819	no value	60s ribosomal protein l18a. [swissprot;acc:q02543]	Subtracted	234.025	224.958	9.067
	POLR2I	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	Divided	228.563	238.668	1.04421
820	MRPS2	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]		221.716	231.501	1.04413
	RPS19	40s ribosomal protein s19. [swissprot;acc:p39019]	Subtracted	234.025	224.958	9.067
821	IMP4	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	Divided	221.676	231.453	1.0441
	RPL31	60s ribosomal protein l31. [swissprot;acc:p12947]	Subtracted	234.025	224.958	9.067
822	EIF3B	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	Divided	243.067	232.805	1.04408
	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	Subtracted	55	46	9
823	C16orf80	transcription factor iib. [refseq;acc:nm_013242]	Divided	206.068	197.471	1.04354
	MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	Subtracted	55	46	9
824	no value	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]
	SFRS8	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	Divided	206.068	197.471	1.04354
825	no value	40s ribosomal protein s3a. [swissprot;acc:p49241]	Subtracted	225.689	234.674	8.985
	WIPF1	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Divided	206.214	197.614	1.04352
826	HTATIP	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]		223.186	213.912	1.04335
	POLR2J	dna-directed rna polymerase ii 13.3 kda polypeptide (ec 2.7.7.6) (rpb11). [swissprot;acc:p52435]	Subtracted	230.811	239.785	8.974
827	CCDC22	jm1 protein. [refseq;acc:nm_014008]		219.762	210.806	8.956
	LOH12CR1	loh1cr12. [refseq;acc:nm_058169]	Divided	230.087	220.579	1.0431
828	no value	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	Subtracted	135.087	144.041	8.954
	CSDE1	unr protein. [swissprot;acc:o75534]	Divided	230.087	220.579	1.0431
829	ERCC5	dna-repair protein complementing xp-g cells (xeroderma pigmentosum group g complementing protein) (dna excision repair protein ercc-5). [swissprot;acc:p28715]	Subtracted	252.873	261.821	8.948
	SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	Divided	135.844	130.259	1.04288
830	PARK2	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]		231.734	222.222	1.0428
	WDR3	wd-repeat protein 3. [swissprot;acc:q9unx4]	Subtracted	243.896	234.96	8.936
831	no value	60s acidic ribosomal protein p1. [swissprot;acc:p05386]		229.171	238.048	8.877
		hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	Divided	231.734	222.222	1.0428
832		cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]
	TXNDC2	thioredoxin domain-containing 2; sperm-specific thioredoxin; thioredoxin domain-containing 2 (spermatozoa). [refseq;acc:nm_032243]	Subtracted	229.171	238.048	8.877
833	PSIP1	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	Divided	231.734	222.222	1.0428
	TXN	thioredoxin (atl-derived factor) (adf) (surface associated sulphydryl protein) (sasp). [swissprot;acc:p10599]	Subtracted	229.171	238.048	8.877
834	no value	dna directed rna polymerase ii polypeptide j-related gene isoform 3; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_032959]		230.768	239.632	8.864
	RPL8	60s ribosomal protein l8. [swissprot;acc:p25120]	Divided	231.734	222.222	1.0428
835	HDGF	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]
	HNRPK	heterogeneous nuclear ribonucleoprotein k (hnrnp k) (dc-stretch binding protein) (csbp) (transformation upregulated nuclear protein) (tunp). [swissprot;acc:q07244]	Subtracted	224.413	233.272	8.859
836	HDGFL1	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	Divided	231.734	222.222	1.0428
	PRPF4	u4/u6 small nuclear ribonucleoprotein prp4 (u4/u6 snrnp 60 kda protein) (wd splicing factor prp4) (hprp4). [swissprot;acc:o43172]	Subtracted	224.413	233.272	8.859
837	DDX6	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	Divided	231.734	222.222	1.0428
	SSRP1	structure-specific recognition protein 1 (ssrp1) (recombination signal sequence recognition protein) (t160) (chromatin-specific transcription elongation factor 80 kda subunit) (fact 80 kda subunit). [swissprot;acc:q08945]	Subtracted	237.62	228.762	8.858
838	SUPT16H	chromatin-specific transcription elongation factor large subunit. [refseq;acc:nm_007192]
	TMEM131	rw1 protein (fragment). [swissprot;acc:q92545]	Divided	231.734	222.222	1.0428
839	no value	dna directed rna polymerase ii polypeptide j-related gene isoform 1; rpb11b1alpha protein; rpb11b1beta; dna-directed rna polymerase ii subunit 11. [refseq;acc:nm_145325]	Subtracted	230.764	239.62	8.856
	CLEC11A	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	Divided	177.776	170.499	1.04268
840	DEAF1	deformed epidermal autoregulatory factor 1 homolog (nuclear deaf-1 related transcriptional regulator) (nudr) (suppressin) (zinc finger mynd domain containing protein 5). [swissprot;acc:o75398]	Subtracted	236.741	245.547	8.806

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.