MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Value Type	Rank	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1608 to 1657 of 29840 in total

Value Type  : Measured
Interaction Map  : High confidence

Rank	description	Network Comparison Type	Filtered	red	green	network_comparison
402	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	Divided	0	548.5	527.5	1.03981
403	fem-1 homolog b; fem-1-like death receptor binding protein; fem-1 (c.elegans) homolog b. [refseq;acc:nm_015322]		1	5201.41	4479.76	1.16109
	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Subtracted	0	2290.09	2264.37	25.72
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Divided		548.5	527.5	1.03981
	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Subtracted	1	6259.3	7190.91	931.61
404	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]			7802.31	8731.82	929.51
	leucine-rich repeat protein lrrc3 precursor. [swissprot;acc:q9by71]	Divided		5201.41	4479.76	1.16109
	spir-2 protein (fragment). [sptrembl;acc:q8wwl2]	Subtracted	0	31.1429	56.278	25.1351
	thymidylate kinase (ec 2.7.4.9) (dtmp kinase). [swissprot;acc:p23919]	Divided		1229.57	1278.36	1.03968
405	guanine nucleotide-binding protein g(y), alpha subunit (alpha-11). [swissprot;acc:p29992]	Subtracted	1	1836.71	907.546	929.164
	integral membrane protein cii-3b. [sptrembl;acc:o75609]	Divided	0	2218.63	2304.22	1.03858
	laminin gamma-1 chain precursor (laminin b2 chain). [swissprot;acc:p11047]		1	5201.41	4479.76	1.16109
	similar to cg7020 gene product (fragment). [sptrembl;acc:q96ib4]	Subtracted	0	2806.38	2782.56	23.82
406	dna-directed rna polymerase i 16 kda polypeptide (ec 2.7.7.6) (rpa16). [swissprot;acc:q9y2s0]			1915.69	1892.44	23.25
	guanine nucleotide-binding protein g(q), alpha subunit. [swissprot;acc:p50148]		1	1836.71	907.564	929.146
	thymic stromal co-transporter. [refseq;acc:nm_033051]	Divided		5201.41	4479.76	1.16109
	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]		0	2363.32	2454.04	1.03839
407	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Subtracted	1	1836.76	907.741	929.019
	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	Divided	0	3614.24	3481.87	1.03802
	transcription factor 4 (immunoglobulin transcription factor 2) (itf-2) (sl3-3 enhancer factor 2) (sef-2). [swissprot;acc:p15884]	Subtracted		44	21	23
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	Divided	1	6603.41	7664.65	1.16071
408	dok-like protein. [refseq;acc:nm_024872]			6102.59	7081.46	1.1604
	glycerol kinase, testis specific 1 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14409]		0	219.031	227.143	1.03704
	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Subtracted	1	1836.76	907.763	928.997
	zinc finger protein 232. [swissprot;acc:q9uny5]		0	721.814	699.215	22.599
409	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	Divided	1	6102.59	7081.46	1.1604
	glycerol kinase (ec 2.7.1.30) (atp:glycerol 3-phosphotransferase) (glycerokinase) (gk). [swissprot;acc:p32189]		0	219.19	227.308	1.03704
	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Subtracted	1	1836.76	907.774	928.986
	zinc finger protein 24 (zinc finger protein 191) (zinc finger protein kox17) (retinoic acid suppression protein a) (rsg-a). [swissprot;acc:p17028]		0	721.888	699.297	22.591
410	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]		1	6744.05	5815.13	928.92
	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	Divided		6102.59	7081.46	1.1604
	glycerol kinase, testis specific 2 (ec 2.7.1.30) (atp:glycerol 3- phosphotransferase) (glycerokinase) (gk). [swissprot;acc:q14410]		0	218.71	226.81	1.03704
	zinc finger protein 215 (bwscr2 associated zinc-finger protein 2) (baz 2). [swissprot;acc:q9ul58]	Subtracted		721.913	699.324	22.589
411	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]		1	1836.8	907.903	928.897
	transcription initiation factor tfiid 135 kda subunit (tafii-135) (tafii135) (tafii-130) (tafii130). [swissprot;acc:o00268]	Divided	0	31122	30022.4	1.03663
	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]		1	6102.59	7081.46	1.1604
	zinc finger imprinted 2. [swissprot;acc:q9nzv7]	Subtracted	0	722.144	699.577	22.567
412	60s ribosomal protein l39. [swissprot;acc:p02404]	Divided		3024.78	2923.92	1.03449
	alanine aminotransferase (ec 2.6.1.2) (glutamic--pyruvic transaminase) (gpt) (glutamic--alanine transaminase). [swissprot;acc:p24298]	Subtracted		1527.36	1504.85	22.51
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]		1	1836.81	907.978	928.832
	mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	Divided		3594.31	4169.95	1.16015
413	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	Subtracted		1836.81	907.978	928.832
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	Divided	0	613.385	634.192	1.03392
	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]	Subtracted		39.7924	62.2106	22.4182
	vav proto-oncogene. [swissprot;acc:p15498]	Divided	1	6644.99	7707.8	1.15994
414	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]			6744.05	5815.13	1.15974
	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	Subtracted		5051.16	5975.51	924.35
	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	Divided	0	7520.78	7276.12	1.03363
	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	Subtracted		125.5	103.5	22
415	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]		1	7725.1	8647.74	922.64

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.