MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Gene	Rank	description	Hugo	Value Type	Network Comparison Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1601 to 1650 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
801	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	C20orf3	Subtracted	212.386	221.785	9.399
	beta-catenin (pro2286). [swissprot;acc:p35222]	CTNNB1	Divided	224.445	214.894	1.04445
802	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	SNAP29	Subtracted	212.386	221.785	9.399
	testis-specific protein tex28. [swissprot;acc:o15482]	TEX28P2	Divided			1.04425
803	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	C3orf60
	syntaxin 1b. [swissprot;acc:q15531]	STX1B	Subtracted			9.399
804	a kindred of iglon. [refseq;acc:nm_173808]	NEGR1	Divided			1.04425
	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	MRPL28	Subtracted			9.399
805	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	ANKRA2	Divided			1.04425
	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	RFXANK	Subtracted			9.399
806	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	GPR84	Divided			1.04425
	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	GSTZ1	Subtracted	267.447	276.773	9.326
807	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	PPT1	Divided	212.386	221.785	1.04425
	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]	GART	Subtracted	218.521	227.796	9.275
808	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	HTATIP		223.186	213.912	9.274
	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	NAPB	Divided	212.386	221.785	1.04425
809	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	MVD	Subtracted	233.298	242.571	9.273
	syntaxin 16 (syn16). [swissprot;acc:o14662]	STX16	Divided	212.386	221.785	1.04425
810	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	GOSR2
	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	CSNK2A1P	Subtracted	240.194	230.957	9.237
811	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	CSNK2A2
	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	STX1A	Divided	212.386	221.785	1.04425
812	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	NAPA
	putatative 28 kda protein. [refseq;acc:nm_020143]	PNO1	Subtracted	227.241	236.467	9.226
813	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	C20orf3	Divided	212.386	221.785	1.04425
	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	LSM1	Subtracted	228.599	219.399	9.2
814	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	SNAP29	Divided	212.386	221.785	1.04425
	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	TBL3	Subtracted	244.155	234.96	9.195
815	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]	EIF3G		246.354	237.223	9.131
	syntaxin 1b. [swissprot;acc:q15531]	STX1B	Divided	212.386	221.785	1.04425
816	eukaryotic translation initiation factor 3 subunit 10 (eif-3 theta) (eif3 p167) (eif3 p180) (eif3 p185) (eif3a). [swissprot;acc:q14152]	EIF3A	Subtracted	246.354	237.223	9.131
	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	MRPL28	Divided	212.386	221.785	1.04425
817	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	RFXANK
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	CCT3	Subtracted	110.689	101.613	9.076
818	60s ribosomal protein l39. [swissprot;acc:p02404]	no value		234.025	224.958	9.067
	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	RGL1	Divided	168.592	161.452	1.04422
819	60s ribosomal protein l18a. [swissprot;acc:q02543]	no value	Subtracted	234.025	224.958	9.067
	dna-directed rna polymerase ii 14.5 kda polypeptide (ec 2.7.7.6) (rpb9) (rpb14.5). [swissprot;acc:p36954]	POLR2I	Divided	228.563	238.668	1.04421
820	40s ribosomal protein s19. [swissprot;acc:p39019]	RPS19	Subtracted	234.025	224.958	9.067
	mitochondrial 28s ribosomal protein s2 (mrp-s2) (cgi-91). [swissprot;acc:q9y399]	MRPS2	Divided	221.716	231.501	1.04413
821	60s ribosomal protein l31. [swissprot;acc:p12947]	RPL31	Subtracted	234.025	224.958	9.067
	u3 snornp protein 4 homolog. [refseq;acc:nm_033416]	IMP4	Divided	221.676	231.453	1.0441
822	eukaryotic translation initiation factor 3 subunit 9 (eif-3 eta) (eif3 p116) (eif3 p110) (eif3b). [swissprot;acc:p55884]	EIF3B		243.067	232.805	1.04408
	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]	MYO5B	Subtracted	55	46	9
823	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	MYO5C
	transcription factor iib. [refseq;acc:nm_013242]	C16orf80	Divided	206.068	197.471	1.04354
824	myosin va (myosin 5a) (dilute myosin heavy chain, non-muscle) (myosin heavy chain 12) (myoxin). [swissprot;acc:q9y4i1]	no value	Subtracted	55	46	9
	splicing factor, arginine/serine-rich 8 (suppressor of white apricot protein homolog). [swissprot;acc:q12872]	SFRS8	Divided	206.068	197.471	1.04354
825	40s ribosomal protein s3a. [swissprot;acc:p49241]	no value	Subtracted	225.689	234.674	8.985
	wiskott-aldrich syndrome protein interacting protein (wasp interacting protein) (prpl-2 protein). [swissprot;acc:o43516]	WIPF1	Divided	206.214	197.614	1.04352

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.