MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	Value Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1582 to 1631 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Interaction Map	red	green	network_comparison
396	LEPR	Divided	leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	Low confidence	206.88	199.607	1.03644
	RPA1	Subtracted	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	High confidence	207.908	226.218	18.31
	SNRPD3		small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Low confidence	201.176	193.984	7.192
397	CCT3	Divided	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	High confidence	110.689	101.613	1.08932
	LEPROTL1		leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]	Low confidence	206.88	199.607	1.03644
	OXA1L	Subtracted	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]		211.182	203.991	7.191
	RPA2		replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]	High confidence	207.908	226.218	18.31
398	GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Low confidence	207.797	214.954	7.157
	ITGB1BP3	Divided	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	High confidence	218.818	238.358	1.0893
	PDC	Subtracted	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]		207.908	226.218	18.31
	YME1L1	Divided	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	Low confidence	205.997	213.496	1.0364
399	no value	Subtracted	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	197.863	7.154
	CLTC	Divided	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]	High confidence	207.889	226.226	1.08821
	GTF3A		transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Low confidence	193.291	186.506	1.03638
	RAD52	Subtracted	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	226.218	18.31
400	CLTCL1		clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]		207.931	226.209	18.278
	NUBP1		nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Low confidence	200.894	193.766	7.128
	PDCL	Divided	phosducin-like protein (phlp). [swissprot;acc:q13371]	High confidence	207.908	226.218	1.08807
	SLC35E1		solute carrier family 35, member e1. [refseq;acc:nm_024881]	Low confidence	203.661	211.03	1.03618
401	no value		sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	197.863	1.03616
	HTRA1	Subtracted	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]		200.057	192.938	7.119
	MKI67IP		mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	High confidence	254.434	236.224	18.21
	RPA1	Divided	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]		207.908	226.218	1.08807
402	CACNG5	Subtracted	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Low confidence	210.292	203.181	7.111
	NDC80		highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	High confidence	231.802	249.983	18.181
	RPA2	Divided	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]		207.908	226.218	1.08807
	TREX2		x-linked protein sts1769. [swissprot;acc:q99871]	Low confidence	211.253	203.883	1.03615
403	ATRIP		three prime repair exonuclease 1 isoform c; deoxyribonuclease iii, dnaq/mutd (e. coli)-like; 3' repair exonuclease 1; atr interacting protein. [refseq;acc:nm_032166]
	HTRA3	Subtracted	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]		200.049	192.942	7.107
	MACF1		microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	High confidence	228.468	246.338	17.87
	PDC	Divided	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]		207.908	226.218	1.08807
404	DST	Subtracted	bullous pemphigoid antigen 1 isoforms 1/2/3/4/5/8 (230 kda bullous pemphigoid antigen) (bpa) (hemidesmosomal plaque protein) (dystonia musculorum protein) (fragment). [swissprot;acc:q03001]		228.463	246.33	17.867
	GRM2	Divided	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	Low confidence	203.081	196	1.03613
	HTRA4	Subtracted	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]		200.049	192.942	7.107
	RAD52	Divided	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	226.218	1.08807
405	no value		metabotropic glutamate receptor 3 precursor (mglur3). [swissprot;acc:q14832]	Low confidence	203.081	196	1.03613
	AP1G1	Subtracted	adapter-related protein complex 1 gamma 1 subunit (gamma-adaptin) (adaptor protein complex ap-1 gamma-1 subunit) (golgi adaptor ha1/ap1 adaptin gamma-1 subunit) (clathrin assembly protein complex 1 gamma-1 large chain). [swissprot;acc:o43747]		207.442	200.339	7.103
	CLTCL1	Divided	clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]	High confidence	207.931	226.209	1.0879
	GABARAP	Subtracted	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]		65.4586	83.0461	17.5875
406	no value	Divided	transcription factor dp-1 (e2f dimerization partner 1) (drtf1- polypeptide-1) (drtf1). [swissprot;acc:q14186]		265.634	244.304	1.08731
	HTRA2	Subtracted	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Low confidence	200.046	192.943	7.103
	LUC7L2	Divided	luc7-like 2; cgi-74 protein; cgi-59 protein. [refseq;acc:nm_016019]		201.095	194.099	1.03604
	NETO2	Subtracted	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]	High confidence	237.109	254.667	17.558
407	no value		small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Low confidence	201.334	194.242	7.092
	LUC7L	Divided	luc7-like; sarcoplasmic reticulum protein luc7b1. [refseq;acc:nm_018032]		201.123	194.127	1.03604
	MRPS9		28s ribosomal protein s9, mitochondrial precursor (mrp-s9). [swissprot;acc:p82933]	High confidence	239.75	260.544	1.08673
	NETO1	Subtracted	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]		237.109	254.667	17.558
408	CEBPZ	Divided	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]		255.112	234.804	1.08649
	GRM2	Subtracted	metabotropic glutamate receptor 2 precursor (mglur2). [swissprot;acc:q14416]	Low confidence	203.081	196	7.081
	HNRNPU		heterogenous nuclear ribonucleoprotein u (hnrnp u) (scaffold attachment factor a) (saf-a). [swissprot;acc:q00839]	High confidence	237.109	254.667	17.558

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.