MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1580 to 1629 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Hugo	red	network_comparison	green
mad protein (max dimerizer). [swissprot;acc:q05195]	253	MXD1	228	1.11583	204.333
mago nashi protein homolog. [swissprot;acc:p50606]	2864	MAGOH	0.00001	1	0.00001
maguk p55 subfamily member 2 (mpp2 protein) (discs, large homolog 2). [swissprot;acc:q14168]	1467	MPP2	228.513	1.01956	232.983
maguk p55 subfamily member 3 (mpp3 protein) (discs, large homolog 3). [swissprot;acc:q13368]	2088	MPP3	218.124	1.00781	216.433
maguk p55 subfamily member 6 (veli-associated maguk 1) (vam-1). [swissprot;acc:q9nzw5]	1479	MPP6	228.469	1.0192	232.855
major centromere autoantigen b (centromere protein b) (cenp-b). [swissprot;acc:p07199]	3013	CENPB	0.00001	1	0.00001
malate dehydrogenase, cytoplasmic (ec 1.1.1.37). [swissprot;acc:p40925]	3213	MDH1
malate dehydrogenase, mitochondrial precursor (ec 1.1.1.37). [swissprot;acc:p40926]	571	MDH2	238.529	1.06528	254.099
maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	954	GSTZ1	267.447	1.03487	276.773
malonyl-coa decarboxylase, mitochondrial precursor (ec 4.1.1.9) (mcd). [swissprot;acc:o95822]	1634	MLYCD	215.772	1.01494	212.596
mam domain containing glycosylphosphatidylinositol anchor 1; glycosyl-phosphatidyl-inositol-mam. [refseq;acc:nm_153487]	3070	MDGA1	0.00001	1	0.00001
mannose-6-phosphate isomerase (ec 5.3.1.8) (phosphomannose isomerase) (pmi) (phosphohexomutase). [swissprot;acc:p34949]	1522	MPI	219.306	1.01766	223.179
mannose-p-dolichol utilization defect 1 protein (suppressor of lec15 and lec35 glycosylation mutation homolog) (sl15). [swissprot;acc:o75352]	929	MPDU1	225.955	1.03642	218.015
mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]	2	no value	15	1.86667	28
map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	1267	MAPKAPK2	171.231	1.02425	167.177
map/microtubule affinity-regulating kinase 1. [refseq;acc:nm_018650]	922	MARK1	236.741	1.0372	245.547
map/microtubule affinity-regulating kinase 2 isoform b; elkl motif kinase 1; elkl motif kinase. [refseq;acc:nm_004954]	923	MARK2
maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	792	no value	224.244	1.04578	234.511
mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	508	CPA3	177.698	1.07058	190.24
mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	2411	PBLD	194.407	1.00362	193.706
max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]	259	RAB24	227.999	1.11562	204.37
max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	256	MXI1		1.11569	204.357
max protein. [swissprot;acc:p25912]	425	MAX	227.828	1.082	210.561
max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]	258	MXD4	227.999	1.11564	204.366
mbd2 (methyl-cpg-binding protein)-interacting zinc finger protein. [refseq;acc:nm_015517]	2331	MIZF	229.258	1.00452	230.294
mct-1 protein. [refseq;acc:nm_014060]	486	MCTS1	226.313	1.07387	243.03
megf10 protein. [refseq;acc:nm_032446]	1944	MEGF10	224.341	1.00987	222.148
megf11 protein. [refseq;acc:nm_032445]	1943	MEGF11	224.34		222.147
megf6 (fragment). [sptrembl;acc:o75095]	1756	MEGF6	221.811	1.01242	219.09
megsin (tp55) (serpin b7). [swissprot;acc:o75635]	2414	SERPINB7	218.2	1.00359	218.984
meiotic recombination protein dmc1/lim15 homolog. [swissprot;acc:q14565]	2259	DMC1	213.391	1.00569	214.606
meiotic recombination protein spo11. [swissprot;acc:q9y5k1]	924	SPO11	236.741	1.0372	245.547
melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]	816	MRPL28	212.386	1.04425	221.785
melanoma antigen recognized by t cells 2. [refseq;acc:nm_018194]	2495	HHAT	194.527	1.00284	195.08
melanoma antigen, family b, 6. [refseq;acc:nm_173523]	93	MAGEB6B	88.2482	1.24949	110.265
melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	83	MAGED4
melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	99	no value
melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	100	MAGEA10
melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	86	MAGEA11
melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	98	MAGEA4
melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]	87	MAGEA2B
melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	85	no value
melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	94
melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	89	MAGEA6
melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	96	MAGEA8
melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	95	MAGEA9
melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	101	MAGEB4
melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	97	MAGEC1
melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	91	MAGED1
melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	102	MAGED2

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.