MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1580 to 1629 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
790	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Subtracted	212.386	221.785	9.399
791	C3orf60	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	SERPINB9	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	Divided	224.244	234.511	1.04578
792	no value	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Subtracted	212.386	221.785	9.399
793	ANKRA2	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]
	SERPINB10	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	Divided	224.244	234.511	1.04578
794	GPR84	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Subtracted	212.386	221.785	9.399
	SERPINB8	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	Divided	224.244	234.511	1.04578
795	no value	serpin b11. [swissprot;acc:q96p15]
	PPT1	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Subtracted	212.386	221.785	9.399
796	NAPB	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]
	SERPINB6	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	Divided	224.244	234.511	1.04578
797	no value	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	STX16	syntaxin 16 (syn16). [swissprot;acc:o14662]	Subtracted	212.386	221.785	9.399
798	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]
	SERPINB1	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	Divided	224.244	234.511	1.04578
799	SQSTM1	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]		221.965	212.404	1.04501
	STX1A	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Subtracted	212.386	221.785	9.399
800	NAPA	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
	SCP2	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	Divided	221.965	212.404	1.04501
801	C20orf3	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	Subtracted	212.386	221.785	9.399
	CTNNB1	beta-catenin (pro2286). [swissprot;acc:p35222]	Divided	224.445	214.894	1.04445
802	SNAP29	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	Subtracted	212.386	221.785	9.399
	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	Divided			1.04425
803	C3orf60	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	STX1B	syntaxin 1b. [swissprot;acc:q15531]	Subtracted			9.399
804	MRPL28	melanoma antigen p15 (melanoma-associated antigen recognized by t lymphocytes). [swissprot;acc:q13084]
	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	Divided			1.04425
805	ANKRA2	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]
	RFXANK	dna-binding protein rfxank (regulatory factor x subunit b) (rfx-b) (ankyrin repeat family a protein 1). [swissprot;acc:o14593]	Subtracted			9.399
806	GPR84	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	Divided			1.04425
	GSTZ1	maleylacetoacetate isomerase (ec 5.2.1.2) (maai) (glutathione s- transferase zeta 1) (ec 2.5.1.18) (gstz1-1). [swissprot;acc:o43708]	Subtracted	267.447	276.773	9.326
807	GART	trifunctional purine biosynthetic protein adenosine-3 [includes: phosphoribosylamine--glycine ligase (ec 6.3.4.13) (gars) (glycinamide ribonucleotide synthetase) (phosphoribosylglycinamide synthetase); phosphoribosylformylglycinamidine cyclo-ligase (ec 6.3.3.1) (airs) (phosphoribosyl-aminoimidazole synthetase) (air synthase); phosphoribosylglycinamide formyltransferase (ec 2.1.2.2) (gart) (gar transformylase) (5'-phosphoribosylglycinamide transformylase)]. [swissprot;acc:p22102]		218.521	227.796	9.275
	PPT1	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	Divided	212.386	221.785	1.04425
808	HTATIP	60 kda tat interactive protein (tip60) (hiv-1 tat interactive protein) (cpla(2) interacting protein). [swissprot;acc:q92993]	Subtracted	223.186	213.912	9.274
	NAPB	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	Divided	212.386	221.785	1.04425
809	MVD	diphosphomevalonate decarboxylase (ec 4.1.1.33) (mevalonate pyrophosphate decarboxylase) (mevalonate (diphospho)decarboxylase). [swissprot;acc:p53602]	Subtracted	233.298	242.571	9.273
	STX16	syntaxin 16 (syn16). [swissprot;acc:o14662]	Divided	212.386	221.785	1.04425
810	CSNK2A1P	casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	Subtracted	240.194	230.957	9.237
	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	Divided	212.386	221.785	1.04425
811	CSNK2A2	casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	Subtracted	240.194	230.957	9.237
	STX1A	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	Divided	212.386	221.785	1.04425
812	NAPA	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]
	PNO1	putatative 28 kda protein. [refseq;acc:nm_020143]	Subtracted	227.241	236.467	9.226
813	C20orf3	adipocyte plasma membrane-associated protein (bscv protein). [swissprot;acc:q9hdc9]	Divided	212.386	221.785	1.04425
	LSM1	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Subtracted	228.599	219.399	9.2
814	SNAP29	synaptosomal-associated protein 29 (snap-29) (vesicle-membrane fusion protein snap-29) (soluble 29 kda nsf attachment protein). [swissprot;acc:o95721]	Divided	212.386	221.785	1.04425
	TBL3	transducin beta-like 3; wd-repeat protein sazd. [refseq;acc:nm_006453]	Subtracted	244.155	234.96	9.195
815	EIF3G	eukaryotic translation initiation factor 3 subunit 4 (eif-3 delta) (eif3 p44) (eif-3 rna-binding subunit) (eif3 p42) (eif3g). [swissprot;acc:o75821]		246.354	237.223	9.131

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.