MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1575 to 1624 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
788	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Low confidence	200.788	195.605	1.0265
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	High confidence	138.705	132.538	1.04653
789	no value	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]		224.244	234.511	1.04578
	GALNT2	polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	Low confidence	205.859	200.547	1.02649
790	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		200.79	195.608
	RPS21	40s ribosomal protein s21. [swissprot;acc:p35265]	High confidence	224.244	234.511	1.04578
791	GALNTL1	similar to expressed sequence ai415388 (fragment). [sptrembl;acc:q8n428]	Low confidence	205.859	200.547	1.02649
	SERPINB9	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	High confidence	224.244	234.511	1.04578
792	no value	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
	KRR1	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	Low confidence	204.204	198.939	1.02647
793	AGBL3	similar to atp/gtp-binding protein. [sptrembl;acc:q8nem8]		184.195	179.447	1.02646
	SERPINB10	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	High confidence	224.244	234.511	1.04578
794	SERPINB8	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]
	TRMU	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	Low confidence	184.195	179.447	1.02646
795	no value	serpin b11. [swissprot;acc:q96p15]	High confidence	224.244	234.511	1.04578
	CAPNS1	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	Low confidence	202.525	197.308	1.02644
796	GCA	grancalcin. [swissprot;acc:p28676]		202.524
	SERPINB6	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	High confidence	224.244	234.511	1.04578
797	no value	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	ASCC2	asc-1 complex subunit p100. [refseq;acc:nm_032204]	Low confidence	211.636	206.184	1.02644
798	SERPINB1	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	High confidence	224.244	234.511	1.04578
	SRI	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Low confidence	202.524	197.308	1.02644
799	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		201.294	196.11	1.02643
	SQSTM1	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	High confidence	221.965	212.404	1.04501
800	DCUN1D1	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	Low confidence	202.755	197.536	1.02642
	SCP2	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	High confidence	221.965	212.404	1.04501
801	CTNNB1	beta-catenin (pro2286). [swissprot;acc:p35222]		224.445	214.894	1.04445
	PDCD6	programmed cell death protein 6 (probable calcium-binding protein alg- 2). [swissprot;acc:o75340]	Low confidence	202.522	197.311	1.02641
802	C3orf37	dc12 protein. [refseq;acc:nm_020187]		203.345	198.117	1.02639
	TEX28P2	testis-specific protein tex28. [swissprot;acc:o15482]	High confidence	212.386	221.785	1.04425
803	C3orf60	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]
	RPN1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kda subunit precursor (ec 2.4.1.119) (ribophorin i) (rpn-i). [swissprot;acc:p04843]	Low confidence	199.573	194.441	1.02639
804	NEGR1	a kindred of iglon. [refseq;acc:nm_173808]	High confidence	212.386	221.785	1.04425
	TSFM	elongation factor ts, mitochondrial precursor (ef-ts) (ef-tsmt). [swissprot;acc:p43897]	Low confidence	204.519	199.267	1.02636
805	ANKRA2	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	High confidence	212.386	221.785	1.04425
	SYNJ1	synaptojanin 1 (ec 3.1.3.36) (synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1). [swissprot;acc:o43426]	Low confidence	198.496	193.399	1.02635
806	ATP6V1C1	vacuolar atp synthase subunit c (ec 3.6.3.14) (v-atpase c subunit) (vacuolar proton pump c subunit). [swissprot;acc:p21283]		202.369	197.173
	GPR84	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	High confidence	212.386	221.785	1.04425
807	PNKD	myofibrillogenesis regulator 1; trans-activated by hepatitis c virus core protein 2; likely ortholog of mouse brain protein 17. [refseq;acc:nm_022572]	Low confidence	200.782	195.631	1.02633
	PPT1	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	High confidence	212.386	221.785	1.04425
808	HDLBP	vigilin (high density lipoprotein-binding protein) (hdl-binding protein). [swissprot;acc:q00341]	Low confidence	201.169	196.014	1.0263
	NAPB	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	High confidence	212.386	221.785	1.04425
809	PAK1	serine/threonine-protein kinase pak 1 (ec 2.7.1.-) (p21-activated kinase 1) (pak-1) (p65-pak) (alpha-pak). [swissprot;acc:q13153]	Low confidence	202.744	197.552	1.02628
	STX16	syntaxin 16 (syn16). [swissprot;acc:o14662]	High confidence	212.386	221.785	1.04425
810	APPBP1	amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	Low confidence	196.326	191.3	1.02627
	GOSR2	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	High confidence	212.386	221.785	1.04425
811	STX1A	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]
	STX1B	syntaxin 1b. [swissprot;acc:q15531]	Low confidence	211.432	206.021	1.02626
812	NAPA	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	High confidence	212.386	221.785	1.04425
	SLC30A1	zinc transporter 1 (znt-1). [swissprot;acc:q9y6m5]	Low confidence	206.173	200.909	1.0262

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.