MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 158 to 207 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
79	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Subtracted	254.614	202.646	51.968
80	CACNG4	voltage-dependent calcium channel gamma-4 subunit (neuronal voltage- gated calcium channel gamma-4 subunit). [swissprot;acc:q9ubn1]	Divided	254.691	202.668	1.25669
	SON	son protein (son3) (negative regulatory element-binding protein) (nre- binding protein) (dbp-5) (bax antagonist selected in saccharomyces 1) (bass1) (protein c21orf50). [swissprot;acc:p18583]	Subtracted	294.053	242.562	51.491
81	CACNG5	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Divided	254.614	202.646	1.25645
	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]	Subtracted	252.371	202.016	50.355
82	COQ7	ubiquinone biosynthesis protein coq7 homolog (coenzyme q biosynthesis protein 7 homolog) (timing protein clk-1 homolog). [swissprot;acc:q99807]		252.329	202.004	50.325
	GNB5	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	Divided	267.636	335.359	1.25304
83	HOMER1	homer, neuronal immediate early gene, 1b. [refseq;acc:nm_004272]	Subtracted	252.309	201.998	50.311
	MAGED4	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Divided	88.2482	110.265	1.24949
84	HOMER3	homer, neuronal immediate early gene, 3. [refseq;acc:nm_004838]	Subtracted	252.296	201.995	50.301
	MAGEE2	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]	Divided	88.2482	110.265	1.24949
85	no value	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]
	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Subtracted	296.677	247.559	49.118
86	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]		335	286	49
	MAGEA11	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Divided	88.2482	110.265	1.24949
87	MAGEA2B	melanoma-associated antigen 2 (mage-2 antigen). [swissprot;acc:p43356]
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Subtracted	249.663	298.263	48.6
88	no value	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	Divided	88.2482	110.265	1.24949
	RGS19	regulator of g-protein signaling 19 (rgs19) (g-alpha interacting protein) (gaip protein). [swissprot;acc:p49795]	Subtracted	249.663	298.263	48.6
89	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Divided	88.2482	110.265	1.24949
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Subtracted	249.663	298.263	48.6
90	NDN	necdin. [swissprot;acc:q99608]	Divided	88.2482	110.265	1.24949
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]	Subtracted	249.663	298.263	48.6
91	LBX1	transcription factor lbx1. [swissprot;acc:p52954]
	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Divided	88.2482	110.265	1.24949
92	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Subtracted	249.663	298.263	48.6
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Divided	88.2482	110.265	1.24949
93	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Subtracted	249.663	298.263	48.6
94	no value	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Divided	88.2482	110.265	1.24949
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Subtracted	249.663	298.263	48.6
95	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Divided	88.2482	110.265	1.24949
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Subtracted	249.663	298.263	48.6
96	ATF3	cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]		201.949	153.671	48.278
	MAGEA8	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Divided	88.2482	110.265	1.24949
97	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Subtracted	271.752	225.68	46.072
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided	88.2482	110.265	1.24949
98	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	204.641	160.957	43.684
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]	Divided	88.2482	110.265	1.24949
99	no value	jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	204.641	160.957	43.684
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided	88.2482	110.265	1.24949
100	FOSL2	fos-related antigen 2. [swissprot;acc:p15408]	Subtracted	204.641	161.046	43.595
	MAGEA10	melanoma-associated antigen 10 (mage-10 antigen). [swissprot;acc:p43363]	Divided	88.2482	110.265	1.24949
101	FOSB	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	Subtracted	204.641	161.051	43.59
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Divided	88.2482	110.265	1.24949
102	FOSL1	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	Subtracted	204.642	161.068	43.574
	MAGED2	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Divided	88.2482	110.265	1.24949
103	JUNB	transcription factor jun-b. [swissprot;acc:p17275]	Subtracted	201.144	158.868	42.276
	TRO	trophinin. [swissprot;acc:q12816]	Divided	88.2482	110.265	1.24949
104	HOMER2	homer, neuronal immediate early gene, 2; homer homolog 3 (drosophila). [refseq;acc:nm_004839]		252.371	202.016	1.24926

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.