MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Network Comparison Type	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1562 to 1611 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	Interaction Map	red	network_comparison	green
391	HTRA2	Divided	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Low confidence	200.046	1.03681	192.943
	RPS16		40s ribosomal protein s16. [swissprot;acc:p17008]	High confidence	241.828	1.09011	263.62
	TXNL4A	Subtracted	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]		225.719	18.647	207.072
392	LEPR		leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	Low confidence	206.88	7.273	199.607
	NUBP1	Divided	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]		200.894	1.03679	193.766
	POLR3C	Subtracted	polymerase (rna) iii (dna directed) (62kd). [refseq;acc:nm_006468]	High confidence	239.092	18.613	257.705
	RPL13A	Divided	60s ribosomal protein l13a (23 kda highly basic protein). [swissprot;acc:p40429]		241.83	1.09008	263.615
393	no value		small nuclear ribonucleoprotein e (snrnp-e) (sm protein e) (sm-e) (sme). [swissprot;acc:p08578]	Low confidence	201.334	1.03651	194.242
	LEPROTL1	Subtracted	leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]		206.88	7.273	199.607
	POLR3F		dna-directed rna polymerases iii 39 kda polypeptide (ec 2.7.7.6) (rna polymerase iii c39 subunit). [swissprot;acc:q9h1d9]	High confidence	238.921	18.406	257.327
	TXNL4A	Divided	spliceosomal u5 snrnp-specific 15 kda protein (dim1 protein homolog) (thioredoxin-like u5 snrnp protein u5-15kd). [swissprot;acc:o14834]		225.719	1.09005	207.072
394	CLTC	Subtracted	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]		207.889	18.337	226.226
	CRNKL1	Divided	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	Low confidence	204.815	1.03648	197.606
		Subtracted				7.209
	DPP9	Divided	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	High confidence	218.827	1.08948	238.407
395	no value		rna binding protein. [refseq;acc:nm_032509]	Low confidence	206.88	1.03644	199.607
	DPP8		dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	High confidence	218.827	1.08948	238.407
	JPH4	Subtracted	adapter-related protein complex 1 gamma 2 subunit (gamma2-adaptin) (adaptor protein complex ap-1 gamma-2 subunit) (g2ad). [swissprot;acc:o75843]	Low confidence	207.558	7.195	200.363
	PDCL		phosducin-like protein (phlp). [swissprot;acc:q13371]	High confidence	207.908	18.31	226.218
396	no value	Divided	putative eukaryotic translation initiation factor 1a (eif-1a) (eif- 4c). [swissprot;acc:o75642]		240.801	1.08945	262.34
	LEPR		leptin receptor gene-related protein (ob-r gene related protein) (ob- rgrp). [swissprot;acc:o15243]	Low confidence	206.88	1.03644	199.607
	RPA1	Subtracted	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]	High confidence	207.908	18.31	226.218
	SNRPD3		small nuclear ribonucleoprotein sm d3 (snrnp core protein d3) (sm-d3). [swissprot;acc:p43331]	Low confidence	201.176	7.192	193.984
397	CCT3	Divided	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	High confidence	110.689	1.08932	101.613
	LEPROTL1		leptin receptor overlapping transcript-like 1 (my047 protein). [swissprot;acc:o95214]	Low confidence	206.88	1.03644	199.607
	OXA1L	Subtracted	cytochrome oxidase biogenesis protein oxa1, mitochondrial precursor (oxa1-like protein) (oxa1hs). [swissprot;acc:q15070]		211.182	7.191	203.991
	RPA2		replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]	High confidence	207.908	18.31	226.218
398	GNG10		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-10 subunit. [swissprot;acc:p50151]	Low confidence	207.797	7.157	214.954
	ITGB1BP3	Divided	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]	High confidence	218.818	1.0893	238.358
	PDC	Subtracted	phosducin (phd) (33 kda phototransducing protein) (meka protein). [swissprot;acc:p20941]		207.908	18.31	226.218
	YME1L1	Divided	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	Low confidence	205.997	1.0364	213.496
399	no value	Subtracted	sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	7.154	197.863
	CLTC	Divided	clathrin heavy chain 1 (clh-17). [swissprot;acc:q00610]	High confidence	207.889	1.08821	226.226
	GTF3A		transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Low confidence	193.291	1.03638	186.506
	RAD52	Subtracted	dna repair protein rad52 homolog. [swissprot;acc:p43351]	High confidence	207.908	18.31	226.218
400	CLTCL1		clathrin heavy chain 2 (clh-22). [swissprot;acc:p53675]		207.931	18.278	226.209
	NUBP1		nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Low confidence	200.894	7.128	193.766
	PDCL	Divided	phosducin-like protein (phlp). [swissprot;acc:q13371]	High confidence	207.908	1.08807	226.218
	SLC35E1		solute carrier family 35, member e1. [refseq;acc:nm_024881]	Low confidence	203.661	1.03618	211.03
401	no value		sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]		205.017	1.03616	197.863
	HTRA1	Subtracted	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]		200.057	7.119	192.938
	MKI67IP		mki67 (fha domain) interacting nucleolar phosphoprotein; nucleolar phosphoprotein nopp34; nucleolar protein interacting with the fha domain of pki-67. [refseq;acc:nm_032390]	High confidence	254.434	18.21	236.224
	RPA1	Divided	replication protein a 70 kda dna-binding subunit (rp-a) (rf-a) (replication factor-a protein 1) (single-stranded dna-binding protein). [swissprot;acc:p27694]		207.908	1.08807	226.218
402	CACNG5	Subtracted	voltage-dependent calcium channel gamma-5 subunit (neuronal voltage- gated calcium channel gamma-5 subunit). [swissprot;acc:q9uf02]	Low confidence	210.292	7.111	203.181
	NDC80		highly expressed in cancer, rich in leucine heptad repeats. [refseq;acc:nm_006101]	High confidence	231.802	18.181	249.983
	RPA2	Divided	replication protein a 32 kda subunit (rp-a) (rf-a) (replication factor-a protein 2). [swissprot;acc:p15927]		207.908	1.08807	226.218
	TREX2		x-linked protein sts1769. [swissprot;acc:q99871]	Low confidence	211.253	1.03615	203.883
403	ATRIP		three prime repair exonuclease 1 isoform c; deoxyribonuclease iii, dnaq/mutd (e. coli)-like; 3' repair exonuclease 1; atr interacting protein. [refseq;acc:nm_032166]
	HTRA3	Subtracted	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]		200.049	7.107	192.942
	MACF1		microtubule-actin crosslinking factor 1, isoform 4. [swissprot;acc:q96pk2]	High confidence	228.468	17.87	246.338

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.