MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Hugo	description	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1558 to 1607 of 1892 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
green  : 0
network_comparison  : 0

Rank	Hugo	description	Value Type
3145	UPB1	beta-ureidopropionase (ec 3.5.1.6) (beta-alanine synthase) (n-carbamoyl-beta-alanine amidohydrolase) (bup-1). [swissprot;acc:q9ubr1]	Ranked
			Squared
			Rooted
3146	DERL3	putative nadh oxidoreductase complex i subunit homolog. [sptrembl;acc:q96q80]	Measured
			Ranked
			Squared
			Rooted
3147	HSD3B7	3 beta-hydroxy-delta 5-c27-steroid oxidoreductase. [refseq;acc:nm_025193]	Measured
			Ranked
			Squared
			Rooted
3148	no value	muts protein homolog 5. [swissprot;acc:o43196]	Measured
			Ranked
			Squared
			Rooted
3149	BRPF3	bromodomain and phd finger-containing protein 3 (fragment). [swissprot;acc:q9uld4]	Measured
			Ranked
			Squared
			Rooted
3150	CRISP3	cysteine-rich secretory protein-3 precursor (crisp-3) (sgp28 protein). [swissprot;acc:p54108]	Measured
			Ranked
			Squared
			Rooted
3151	MSH2	dna mismatch repair protein msh2. [swissprot;acc:p43246]	Measured
			Ranked
			Squared
			Rooted
3152	HDAC6	histone deacetylase 6 (hd6). [swissprot;acc:q9ubn7]	Measured
			Ranked
			Squared
			Rooted
3153	LRRFIP2	leucine rich repeat (in flii) interacting protein 2. [refseq;acc:nm_006309]	Measured
			Ranked
			Squared
			Rooted
3154	NUP50	nucleoporin 50 kda (nuclear pore-associated protein 60 kda-like) (pro1146). [swissprot;acc:q9ukx7]	Measured
			Ranked
			Squared
			Rooted
3155	TGFB2	transforming growth factor beta 2 precursor (tgf-beta 2) (glioblastoma-derived t-cell suppressor factor) (g-tsf) (bsc-1 cell growth inhibitor) (polyergin) (cetermin). [swissprot;acc:p08112]	Measured
			Ranked
			Squared
			Rooted
3156	TEKT2	tektin 2 (tektin-t) (testicular tektin b1-like protein). [swissprot;acc:q9uif3]	Measured
			Ranked
			Squared
			Rooted
3157	SCFD1	vesicle transport-related protein isoform a; vesicle transport-related protein. [refseq;acc:nm_016106]	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.