MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Gene	Network Comparison Type	Rank	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1558 to 1607 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

description	Network Comparison Type	Rank	Value Type	Hugo	red	network_comparison	green
adapter-related protein complex 1 sigma 1a subunit (sigma-adaptin 1a) (adaptor protein complex ap-1 sigma-1a subunit) (golgi adaptor ha1/ap1 adaptin sigma-1a subunit) (clathrin assembly protein complex 1 sigma- 1a small chain) (clathrin coat assembly protein ap19) (ha1 19 kda subunit) (sigma 1a subunit of ap-1 clathrin). [swissprot;acc:q00382]	Subtracted	1792	Squared	AP1S1	25481.8	2282.3	27764.1
		2089	Measured		5552.69	313.15	5865.84
		2441	Rooted		60.4127	0.855	61.2677
adapter-related protein complex 1 sigma 1b subunit (sigma-adaptin 1b) (adaptor protein complex ap-1 sigma-1b subunit) (golgi adaptor ha1/ap1 adaptin sigma-1b subunit) (clathrin assembly protein complex 1 sigma- 1b small chain) (sigma 1b subunit of ap-1 clathrin) (dc22). [swissprot;acc:p56377]	Divided	1595	Ranked	no value	222.134	1.01619	225.731
		2058	Measured		5552.69	1.0564	5865.84
		2076	Squared		25481.8	1.08957	27764.1
		2438	Rooted		60.4127	1.01415	61.2677
	Subtracted	1565	Ranked		222.134	3.597	225.731
		1790	Squared		25481.8	2282.3	27764.1
		2086	Measured		5552.69	313.15	5865.84
		2438	Rooted		60.4127	0.855	61.2677
adapter-related protein complex 1 sigma 1c subunit (sigma-adaptin 1c) (adaptor protein complex ap-1 sigma-1c subunit) (golgi adaptor ha1/ap1 adaptin sigma-1c subunit) (clathrin assembly protein complex 1 sigma- 1c small chain) (sigma 1c subunit of ap-1 clathrin). [swissprot;acc:q96pc3]	Divided	1597	Ranked	AP1S3	222.134	1.01619	225.731
		2060	Measured		5552.69	1.0564	5865.84
		2077	Squared		25481.8	1.08957	27764.1
		2440	Rooted		60.4127	1.01415	61.2677
	Subtracted	1567	Ranked		222.134	3.597	225.731
		1791	Squared		25481.8	2282.3	27764.1
		2088	Measured		5552.69	313.15	5865.84
		2440	Rooted		60.4127	0.855	61.2677
adapter-related protein complex 2 beta 1 subunit (beta-adaptin) (plasma membrane adaptor ha2/ap2 adaptin beta subunit) (clathrin assembly protein complex 2 beta large chain) (ap105b). [swissprot;acc:p21851]	Divided	1600	Ranked	AP2B1	222.103	1.01608	225.675
		2050	Measured		5556.36	1.05647	5870.11
		2082	Squared		25510.2	1.08956	27794.9
		2429	Rooted		60.43	1.01426	61.2917
	Subtracted	1575	Ranked		222.103	3.572	225.675
		1789	Squared		25510.2	2284.7	27794.9
		2083	Measured		5556.36	313.75	5870.11
		2430	Rooted		60.43	0.8617	61.2917
adapter-related protein complex 3 beta 1 subunit (beta-adaptin 3a) (ap-3 complex beta-3a subunit) (beta-3a-adaptin). [swissprot;acc:o00203]	Divided	2044	Ranked	AP3B1	199.928	1.00851	198.24
		2376	Rooted		68.9441	1.01649	70.0808
		2623	Measured		6815.24	1.01481	6916.14
		2726	Squared		30233.2	1.01121	29898.1
	Subtracted	2071	Ranked		199.928	1.688	198.24
		2349	Rooted		68.9441	1.1367	70.0808
		2563	Measured		6815.24	100.9	6916.14
		2689	Squared		30233.2	335.1	29898.1
adapter-related protein complex 3 beta 2 subunit (beta-adaptin 3b) (ap-3 complex beta-3b subunit) (beta-3b-adaptin) (neuron-specific vesicle coat protein beta-nap). [swissprot;acc:q13367]	Divided	2046	Ranked	no value	199.928	1.00851	198.24
		2378	Rooted		68.9441	1.01649	70.0808
		2625	Measured		6815.24	1.01481	6916.14
		2728	Squared		30233.2	1.01121	29898.1
	Subtracted	2073	Ranked		199.928	1.688	198.24
		2351	Rooted		68.9441	1.1367	70.0808
		2565	Measured		6815.24	100.9	6916.14
		2691	Squared		30233.2	335.1	29898.1
adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	Divided	1098	Ranked	AP3M1	217.323	1.02906	211.185
		1470	Rooted		64.2947	1.03847	66.7681
		2444	Measured		6478.14	1.03358	6695.67
		2522	Squared		33471.2	1.05543	31713.3
	Subtracted	1061	Ranked		217.323	6.138	211.185
		1415	Rooted		64.2947	2.4734	66.7681
		2203	Squared		33471.2	1757.9	31713.3

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.