MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
776	no value	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	High confidence	225.996	215.535	1.04854
	MAD1L1	mad1-like 1; mad1 (mitotic arrest deficient, yeast, homolog)-like 1; mitotic-arrest deficient 1, yeast, homolog-like 1; tumor protein p53 inducible protein 9. [refseq;acc:nm_003550]	Low confidence	208.017	202.601	1.02673
777	AP1S3	adapter-related protein complex 1 sigma 1c subunit (sigma-adaptin 1c) (adaptor protein complex ap-1 sigma-1c subunit) (golgi adaptor ha1/ap1 adaptin sigma-1c subunit) (clathrin assembly protein complex 1 sigma- 1c small chain) (sigma 1c subunit of ap-1 clathrin). [swissprot;acc:q96pc3]		204.807	199.484	1.02668
	HDAC1	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	High confidence	225.989	215.53	1.04853
778	SNX6	sorting nexin 6 (traf4-associated factor 2). [swissprot;acc:q9unh7]		209.191	219.332	1.04848
	WDR26	wd repeat domain 26. [refseq;acc:nm_025160]	Low confidence	188.145	183.258	1.02667
779	ABI2	abl-interactor 2; abl-interacting protein 1 (sh3-containing protein); abl binding protein 3; arg protein tyrosine kinase-binding protein; abl-interactor protein 2b; similar to spectrin sh3 domain binding protein 1. [refseq;acc:nm_005759]		202.48	197.229	1.02662
	DCTD	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]	High confidence	230.516	241.641	1.04826
780	no value	importin 9. [refseq;acc:nm_018085]	Low confidence	204.192	198.902	1.0266
	POLR2F	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	High confidence	232.762	243.933	1.04799
781	MRTO4	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]		245.84	257.636	1.04798
	PRMT7	protein arginine n-methyltransferase (ec 2.1.1.-). [swissprot;acc:q9nvm4]	Low confidence	203.591	198.319	1.02658
782	no value	translin. [swissprot;acc:q15631]	High confidence	224.385	235.131	1.04789
	PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]	Low confidence	203.591	198.319	1.02658
783	HMBS	porphobilinogen deaminase (ec 4.3.1.8) (hydroxymethylbilane synthase) (hmbs) (pre-uroporphyrinogen synthase) (pbg-d). [swissprot;acc:p08397]		204.238	198.951	1.02657
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	High confidence	224.385	235.131	1.04789
784	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Low confidence	201.338	196.126	1.02657
785	ABI1	spectrin sh3 domain binding protein 1; eps8 binding protein; interactor protein ablbp4; abl-interactor protein 1 long; nap1 binding protein. [refseq;acc:nm_005470]		202.469	197.233	1.02655
	NET1	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	High confidence	244.447	233.508	1.04685
786	ARHGEF3	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]
	FBXL11	f-box and leucine-rich repeat protein 11; f-box protein fbl11. [refseq;acc:nm_012308]	Low confidence	202.957	208.337	1.02651
787	ATP6V1C2	atpase, h+ transporting, lysosomal 42kda, v1 subunit c isoform 2; v-atpase c2 subunit. [refseq;acc:nm_144583]		202.489	197.259
	UTP20	down-regulated in metastasis. [refseq;acc:nm_014503]	High confidence	244.447	233.508	1.04685
788	EIF4G3	eukaryotic translation initiation factor 4 gamma, 3. [refseq;acc:nm_003760]	Low confidence	200.788	195.605	1.0265
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	High confidence	138.705	132.538	1.04653
789	no value	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]		224.244	234.511	1.04578
	GALNT2	polypeptide n-acetylgalactosaminyltransferase 2; udp-galnac transferase 2. [refseq;acc:nm_004481]	Low confidence	205.859	200.547	1.02649
790	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		200.79	195.608
	RPS21	40s ribosomal protein s21. [swissprot;acc:p35265]	High confidence	224.244	234.511	1.04578
791	GALNTL1	similar to expressed sequence ai415388 (fragment). [sptrembl;acc:q8n428]	Low confidence	205.859	200.547	1.02649
	SERPINB9	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	High confidence	224.244	234.511	1.04578
792	no value	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]
	KRR1	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]	Low confidence	204.204	198.939	1.02647
793	AGBL3	similar to atp/gtp-binding protein. [sptrembl;acc:q8nem8]		184.195	179.447	1.02646
	SERPINB10	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	High confidence	224.244	234.511	1.04578
794	SERPINB8	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]
	TRMU	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	Low confidence	184.195	179.447	1.02646
795	no value	serpin b11. [swissprot;acc:q96p15]	High confidence	224.244	234.511	1.04578
	CAPNS1	calcium-dependent protease, small subunit (calpain regulatory subunit) (calcium-activated neutral proteinase) (canp). [swissprot;acc:p04632]	Low confidence	202.525	197.308	1.02644
796	GCA	grancalcin. [swissprot;acc:p28676]		202.524
	SERPINB6	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	High confidence	224.244	234.511	1.04578
797	no value	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]
	ASCC2	asc-1 complex subunit p100. [refseq;acc:nm_032204]	Low confidence	211.636	206.184	1.02644
798	SERPINB1	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	High confidence	224.244	234.511	1.04578
	SRI	sorcin (22 kda protein) (cp-22) (v19). [swissprot;acc:p30626]	Low confidence	202.524	197.308	1.02644
799	AMPD2	amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]		201.294	196.11	1.02643
	SQSTM1	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	High confidence	221.965	212.404	1.04501
800	DCUN1D1	rp42 homolog; squamous cell carcinoma-related oncogene. [refseq;acc:nm_020640]	Low confidence	202.755	197.536	1.02642
	SCP2	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	High confidence	221.965	212.404	1.04501

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.