MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
cone-rod homeobox protein. [swissprot;acc:o43186]	1156	CRX	Low confidence	205.625	200.934	1.02335
	1519		High confidence	244.331	240.061	1.01779
connective tissue growth factor precursor (hypertrophic chondrocyte- specific protein 24). [swissprot;acc:p29279]	1282	CTGF	Low confidence	208.383	203.805	1.02246
	3040		High confidence	0.00001	0.00001	1
connective tissue growth factor-like protein precursor (ctgf-l) (wnt1 inducible signaling pathway protein 2) (wisp-2) (connective tissue growth factor-related protein 58). [swissprot;acc:o76076]	1457	WISP2	Low confidence	208.154	203.755	1.02159
	3188		High confidence	0.00001	0.00001	1
conserved oligomeric golgi complex component 1. [swissprot;acc:q8wtw3]	2836	COG1
	4125		Low confidence	197.858	195.778	1.01062
conserved oligomeric golgi complex component 2 (low density lipoprotein receptor defect c-complementing protein). [swissprot;acc:q14746]	1213	COG2	High confidence	214.364	219.759	1.02517
	3827		Low confidence	202.207	199.576	1.01318
conserved oligomeric golgi complex component 3 (vesicle docking protein sec34 homolog) (p94). [swissprot;acc:q96jb2]	354	COG3		206.433	198.781	1.03849
	2627		High confidence	224.891	225.195	1.00135
conserved oligomeric golgi complex component 4. [swissprot;acc:q9h9e3]	3425	COG4	Low confidence	199.066	196.08	1.01523
conserved oligomeric golgi complex component 6. [swissprot;acc:q9y2v7]	2110	COG6	High confidence	211.099	209.607	1.00712
	2941		Low confidence	200.603	197.255	1.01697
conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]	2750	COG7	High confidence	190.522	190.496	1.00014
	3848		Low confidence	200.983	198.394	1.01305
conserved oligomeric golgi complex subunit 5 (13s golgi transport complex 90 kda subunit) (gtc-90) (golgi transport complex 1). [swissprot;acc:q9up83]	194	COG5		215.723	205.046	1.05207
	493		High confidence	220.172	235.98	1.0718
contactin 2 precursor (axonin-1) (axonal glycoprotein tag-1) (transient axonal glycoprotein 1) (tax-1). [swissprot;acc:q02246]	4778	CNTN2	Low confidence	201.633	200.734	1.00448
contactin 5 isoform long; neural adhesion molecule. [refseq;acc:nm_014361]	4779	CNTN5
contactin 6; neural adhesion molecule. [refseq;acc:nm_014461]	4780	CNTN6
contactin associated protein 1 precursor (caspr) (caspr1) (neurexin 4) (neurexin iv) (p190). [swissprot;acc:p78357]	2098	CNTNAP1		208.784	204.84	1.01925
contactin associated protein-like 3 precursor (cell recognition molecule caspr3). [swissprot;acc:q9bz76]	2100	CNTNAP3
contactin associated protein-like 4 precursor (cell recognition molecule caspr4). [swissprot;acc:q9c0a0]	2097	CNTNAP4
contactin precursor (glycoprotein gp135). [swissprot;acc:q12860]	4783	CNTN1		201.633	200.734	1.00448
cop-coated vesicle membrane protein p24 precursor (p24a). [swissprot;acc:q15363]	2564	TMED2		191.257	187.872	1.01802
	3168		High confidence	0.00001	0.00001	1
cop9 complex subunit 4; likely ortholog of mouse cop9 (constitutive photomorphogenic), subunit 4 (arabidopsis); cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 4. [refseq;acc:nm_016129]	1500	COPS4		213.398	209.52	1.01851
	4804		Low confidence	202.289	201.442	1.0042
cop9 complex subunit 7a; cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 7a. [refseq;acc:nm_016319]	3881	COPS7A		201.889	199.344	1.01277
cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]	175	COPS3	High confidence	199.949	234.187	1.17123
	3111		Low confidence	202.948	199.66	1.01647
cop9 constitutive photomorphogenic homolog subunit 5; jun activation domain-binding protein. [refseq;acc:nm_006837]	2380	COPS5	High confidence	212.724	213.574	1.004
	3235		Low confidence	203.497	200.309	1.01592
cop9 constitutive photomorphogenic homolog subunit 7b; likely ortholog of cop9 (constitutive photomorphogenic), subunit 7b (arabidopsis); cop9 (constitutive photomorphogenic, arabidopsis, homolog) subunit 7b. [refseq;acc:nm_022730]	3889	COPS7B		201.902	199.364	1.01273
cop9 signalosome complex subunit 1 (g protein pathway suppressor 1) (gps1 protein) (mfh protein). [swissprot;acc:q13098]	2827	GPS1	High confidence	0.00001	0.00001	1
	3108		Low confidence	202.948	199.66	1.01647
cop9 signalosome complex subunit 2 (signalosome subunit 2) (sgn2) (thyroid receptor interacting protein 15) (trip15). [swissprot;acc:q15647]	2841	COPS2	High confidence	0.00001	0.00001	1
	3109		Low confidence	202.948	199.66	1.01647
cop9 subunit 6 (mov34 homolog, 34 kd). [refseq;acc:nm_006833]	2374	COPS6	High confidence	212.724	213.574	1.004
	3396		Low confidence	203.337	200.271	1.01531
copper chaperone for superoxide dismutase (superoxide dismutase copper chaperone). [swissprot;acc:o14618]	3520	CCS		204.208	201.229	1.0148
copper-transporting atpase 1 (ec 3.6.3.4) (copper pump 1) (menkes disease-associated protein). [swissprot;acc:q04656]	2352	ATP7A	High confidence	215.088	214.155	1.00436
	2653		Low confidence	196.576	193.151	1.01773
copper-transporting atpase 2 (ec 3.6.3.4) (copper pump 2) (wilson disease-associated protein). [swissprot;acc:p35670]	2354	ATP7B	High confidence	215.078	214.148	1.00434
	2630		Low confidence	196.453	193.02	1.01779
coproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox). [swissprot;acc:p36551]	2617	CPOX	High confidence	202.821	202.54	1.00139
	2810		Low confidence	200.867	197.457	1.01727
core promoter element-binding protein (kruppel-like factor 6) (b-cell derived protein 1) (proto-oncogene bcd1) (transcription factor zf9) (gc-rich sites binding factor gbf). [swissprot;acc:q99612]	4285	KLF6		197.808	195.976	1.00935

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.