MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1551 to 1600 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
776	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	no value	Divided	225.996	215.535	1.04854
	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	SQSTM1	Subtracted	221.965	212.404	9.561
777	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	HDAC1	Divided	225.989	215.53	1.04853
	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	SCP2	Subtracted	221.965	212.404	9.561
778	beta-catenin (pro2286). [swissprot;acc:p35222]	CTNNB1		224.445	214.894	9.551
	sorting nexin 6 (traf4-associated factor 2). [swissprot;acc:q9unh7]	SNX6	Divided	209.191	219.332	1.04848
779	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]	DCTD		230.516	241.641	1.04826
	parkinson disease (autosomal recessive, juvenile) 2, parkin isoform 1; parkin. [refseq;acc:nm_004562]	PARK2	Subtracted	231.734	222.222	9.512
780	dna-directed rna polymerase ii 14.4 kda polypeptide (ec 2.7.7.6) (rpb6) (rpb14.4) (rpabc2). [swissprot;acc:p41584]	POLR2F	Divided	232.762	243.933	1.04799
	hepatoma-derived growth factor-related protein 2. [refseq;acc:nm_032631]	no value	Subtracted	231.734	222.222	9.512
781	cgi-142; hepatoma-derived growth factor 2. [refseq;acc:nm_016073]
	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	MRTO4	Divided	245.84	257.636	1.04798
782	pc4 and sfrs1 interacting protein 2; pc4 and sfrs1 interacting protein 1; transcriptional coactivator p52/p75. [refseq;acc:nm_033222]	PSIP1	Subtracted	231.734	222.222	9.512
	translin. [swissprot;acc:q15631]	no value	Divided	224.385	235.131	1.04789
783	60s ribosomal protein l8. [swissprot;acc:p25120]	RPL8	Subtracted	231.734	222.222	9.512
	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	TSNAX	Divided	224.385	235.131	1.04789
784	hepatoma-derived growth factor (hdgf) (high-mobility group protein 1- like 2) (hmg-1l2). [swissprot;acc:p51858]	HDGF	Subtracted	231.734	222.222	9.512
	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	PQBP1	Divided	224.385	235.131	1.04789
785	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	NET1		244.447	233.508	1.04685
	pwwp domain containing 1; hdgf (hepatoma-derived growth factor) like. [refseq;acc:nm_138574]	HDGFL1	Subtracted	231.734	222.222	9.512
786	probable atp-dependent rna helicase p54 (oncogene rck) (dead-box protein 6). [swissprot;acc:p26196]	DDX6
	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	ARHGEF3	Divided	244.447	233.508	1.04685
787	down-regulated in metastasis. [refseq;acc:nm_014503]	UTP20
	rw1 protein (fragment). [swissprot;acc:q92545]	TMEM131	Subtracted	231.734	222.222	9.512
788	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	NFU1	Divided	138.705	132.538	1.04653
	loh1cr12. [refseq;acc:nm_058169]	LOH12CR1	Subtracted	230.087	220.579	9.508
789	40s ribosomal protein sa (p40) (34/67 kda laminin receptor) (colon carcinoma laminin-binding protein) (nem/1chd4) (multidrug resistance- associated protein mgr1-ag). [swissprot;acc:p08865]	no value	Divided	224.244	234.511	1.04578
	unr protein. [swissprot;acc:o75534]	CSDE1	Subtracted	230.087	220.579	9.508
790	40s ribosomal protein s21. [swissprot;acc:p35265]	RPS21	Divided	224.244	234.511	1.04578
	testis-specific protein tex28. [swissprot;acc:o15482]	TEX28P2	Subtracted	212.386	221.785	9.399
791	cytoplasmic antiproteinase 3 (cap3) (cap-3) (protease inhibitor 9) (serpin b9). [swissprot;acc:p50453]	SERPINB9	Divided	224.244	234.511	1.04578
	similar to nuclear protein e3-3 orf1. [sptrembl;acc:q9bu61]	C3orf60	Subtracted	212.386	221.785	9.399
792	a kindred of iglon. [refseq;acc:nm_173808]	NEGR1
	maspin precursor (protease inhibitor 5). [swissprot;acc:p36952]	no value	Divided	224.244	234.511	1.04578
793	ankyrin-repeat family a protein 2 (rfxank-like 2). [swissprot;acc:q9h9e1]	ANKRA2	Subtracted	212.386	221.785	9.399
	bomapin (protease inhibitor 10) (serpin b10). [swissprot;acc:p48595]	SERPINB10	Divided	224.244	234.511	1.04578
794	inflammation-related g protein-coupled receptor ex33. [refseq;acc:nm_020370]	GPR84	Subtracted	212.386	221.785	9.399
	plasminogen activator inhibitor-2 precursor (pai-2) (placental plasminogen activator inhibitor) (monocyte arg-serpin) (urokinase inhibitor). [swissprot;acc:p05120]	SERPINB8	Divided	224.244	234.511	1.04578
795	palmitoyl-protein thioesterase 1 precursor (ec 3.1.2.22) (palmitoyl- protein hydrolase 1). [swissprot;acc:p50897]	PPT1	Subtracted	212.386	221.785	9.399
	serpin b11. [swissprot;acc:q96p15]	no value	Divided	224.244	234.511	1.04578
796	beta-soluble nsf attachment protein (snap-beta) (n-ethylmaleimide- sensitive factor attachment protein, beta). [swissprot;acc:q9h115]	NAPB	Subtracted	212.386	221.785	9.399
	placental thrombin inhibitor (cytoplasmic antiproteinase) (cap) (protease inhibitor 6) (pi-6). [swissprot;acc:p35237]	SERPINB6	Divided	224.244	234.511	1.04578
797	cytoplasmic antiproteinase 2 (cap2) (cap-2) (protease inhibitor 8) (serpin b8). [swissprot;acc:p50452]	no value
	syntaxin 16 (syn16). [swissprot;acc:o14662]	STX16	Subtracted	212.386	221.785	9.399
798	27 kda golgi snare protein (golgi snap receptor complex member 2) (membrin). [swissprot;acc:o14653]	GOSR2
	leukocyte elastase inhibitor (lei) (monocyte/neutrophil elastase inhibitor) (m/nei) (ei). [swissprot;acc:p30740]	SERPINB1	Divided	224.244	234.511	1.04578
799	sequestosome 1; ubiquitin-binding protein p62; phosphotyrosine independent ligand for the lck sh2 domain p62. [refseq;acc:nm_003900]	SQSTM1		221.965	212.404	1.04501
	syntaxin 1a (neuron-specific antigen hpc-1). [swissprot;acc:q16623]	STX1A	Subtracted	212.386	221.785	9.399
800	alpha-soluble nsf attachment protein (snap-alpha) (n-ethylmaleimide- sensitive factor attachment protein, alpha). [swissprot;acc:p54920]	NAPA
	nonspecific lipid-transfer protein, mitochondrial precursor (nsl-tp) (sterol carrier protein 2) (scp-2) (sterol carrier protein x) (scp-x) (scpx). [swissprot;acc:p22307]	SCP2	Divided	221.965	212.404	1.04501

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.