MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Network Comparison Type	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1530 to 1579 of 66312 in total

Filtered  : 1

Rank	Hugo	description	Network Comparison Type	Value Type	Interaction Map	red	network_comparison	green
96	PTPRA	vacuolar protein sorting 16 (hvps16). [swissprot;acc:q9h269]	Subtracted	Rooted	Low confidence	69.0723	6.3531	75.4254
	RBM15	putative rna-binding protein 15 (rna binding motif protein 15) (one-twenty two protein). [swissprot;acc:q96t37]	Divided		High confidence	47.6504	1.29028	36.9304
	SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]		Squared	Low confidence	63597.2	1.1821	75178.4
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Subtracted	Measured	High confidence	16177.9	3057.5	19235.4
				Squared		90226	36713	126939
	SLC7A7	y+l amino acid transporter 1 (y(+)l-type amino acid transporter 1) (y+lat-1) (y+lat1) (monocyte amino acid permease 2) (mop-2). [swissprot;acc:q9um01]	Divided	Ranked	Low confidence	200.497	1.0798	185.679
			Subtracted				14.818
97	APBA1	amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	Divided	Measured	High confidence	2820.51	1.3817	3897.1
			Subtracted	Ranked		271.752	46.072	225.68
				Rooted	Low confidence	60.7884	6.3252	67.1136
	CPSF4	cleavage and polyadenylation specific factor 4, 30kd subunit; cleavage-polyadenylation specificity factor, 30kd; no arches-like (zebrafish) zinc finger protein; cleavage-polyadenylation specificity factor. [refseq;acc:nm_006693]	Divided	Squared	High confidence	227160	1.55505	146079
	CSTF2	cleavage stimulation factor, 64 kda subunit (cstf 64 kda subunit) (cf-1 64 kda subunit). [swissprot;acc:p33240]	Subtracted			126408	36467.5	89940.5
	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	Divided	Rooted	Low confidence	68.5063	1.09027	74.6906
	GNAI1	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	Subtracted		High confidence	40.2797	15.9092	24.3705
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase (ec 1.13.11.6) (3-hao) (3-hydroxyanthranilic acid dioxygenase) (3-hydroxyanthranilate oxygenase). [swissprot;acc:p46952]		Measured	Low confidence	10696.6	942.9	11639.5
	KIF23	kinesin-like protein kif23 (mitotic kinesin-like protein-1) (kinesin- like protein 5). [swissprot;acc:q02241]		Squared		57471.1	9007.7	48463.4
	MAGEC1	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]	Divided	Ranked	High confidence	88.2482	1.24949	110.265
	NDUFA12	nadh-ubiquinone oxidoreductase subunit b17.2 (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b17.2) (ci-b17.2) (cib17.2) (13 kda differentiation-associated protein). [swissprot;acc:q9ui09]		Measured	Low confidence	5811.84	1.1011	6399.42
	RAB26	ras-related protein rab-26. [swissprot;acc:q9ulw5]		Squared		61365.7	1.17909	52044.8
	RGS20	regulator of g-protein signaling 20 (rgs20) (regulator of gz- selective protein signaling 1) (gz-selective gtpase-activating protein) (g(z)gap). [swissprot;acc:o76081]		Rooted	High confidence	47.6504	1.29028	36.9304
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	Measured		16067.4	3027	19094.4
	SLC7A11	cystine/glutamate transporter (amino acid transport system xc-) (xct) (calcium channel blocker resistance protein ccbr1). [swissprot;acc:q9upy5]	Divided	Ranked	Low confidence	200.497	1.0798	185.679
			Subtracted				14.818
98	BRP44	brain protein 44. [swissprot;acc:o95563]		Measured	High confidence	15999.1	3008	19007.1
	CYLD	cylindromatosis (turban tumor syndrome); cylindromatosis 1, turban tumor syndrome. [refseq;acc:nm_015247]		Squared	Low confidence	57471.1	9007.7	48463.4
	DNASE2B	deoxyribonuclease ii beta isoform 1 precursor; deoxyribonuclease ii beta; endonuclease dlad. [refseq;acc:nm_021233]	Divided	Rooted		173.58	1.08981	189.17
	FOS	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	Subtracted	Ranked	High confidence	204.641	43.684	160.957
	GNAI3	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]		Rooted		40.2797	15.9092	24.3705
	GTF3A	transcription factor iiia (factor a) (tfiiia). [swissprot;acc:q92664]	Divided	Measured	Low confidence	7624.8	1.1006	8391.85
	KIAA1012	trs85 homolog. [swissprot;acc:q9y2l5]		Squared	High confidence	227160	1.55505	146079
	LBX1	transcription factor lbx1. [swissprot;acc:p52954]		Rooted		47.6504	1.29028	36.9304
	MAGEA4	melanoma-associated antigen 12 (mage-12 antigen) (mage12f). [swissprot;acc:p43365]		Ranked		88.2482	1.24949	110.265
	MTUS1	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]	Subtracted	Rooted	Low confidence	63.1259	6.3046	69.4305
	PHF12	phd finger protein 12; phd zinc finger transcription factor. [refseq;acc:nm_020889]	Divided	Squared		61253.4	1.17845	51977.8
	PSCD2	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	Measured		12376.5	940	11436.5
	PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Divided		High confidence	2353.63	1.3705	3225.65
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Subtracted	Squared		89578.7	36304.3	125883
	SLC7A6	solute carrier family 7 (cationic amino acid transporter, y+ system), member 6. [refseq;acc:nm_003983]	Divided	Ranked	Low confidence	200.497	1.0798	185.679
			Subtracted				14.818
99	no value	cysteine-rich protein 1 (cysteine-rich intestinal protein) (crip) (cysteine-rich heart protein) (hcrhp). [swissprot;acc:p50238]	Divided	Measured		5752.65	1.10037	6330.03
		jun dimerization protein. [refseq;acc:nm_130469]	Subtracted	Ranked	High confidence	204.641	43.684	160.957
		mannosyl-oligosaccharide 1,2-alpha-mannosidase ib (ec 3.2.1.113) (processing alpha-1,2-mannosidase ib) (alpha-1,2-mannosidase ib) (mannosidase alpha class 1a member 2). [swissprot;acc:o60476]		Measured	Low confidence	12376.4	939.9	11436.5
		melanoma-associated antigen 1 (mage-1 antigen) (antigen mz2-e). [swissprot;acc:p43355]	Divided	Ranked	High confidence	88.2482	1.24949	110.265
	BRP44	brain protein 44. [swissprot;acc:o95563]	Subtracted	Squared		89182.8	36046.2	125229
	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	Divided	Rooted	Low confidence	68.5805	1.08931	74.7056
	EIF4B	eukaryotic translation initiation factor 4b (eif-4b). [swissprot;acc:p23588]		Ranked		200.497	1.0798	185.679
			Subtracted				14.818
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Divided	Rooted	High confidence	47.6504	1.29028	36.9304
	NFU1	hira-interacting protein 5 (cgi-33). [swissprot;acc:q9ums0]	Subtracted		Low confidence	96.9641	6.2779	103.242
	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]	Divided	Squared		61163.4	1.17794	51924

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.