MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1525 to 1574 of 3228 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	red	green	network_comparison
1525	protocadherin fat 2 precursor (hfat2) (multiple epidermal growth factor-like domains 1). [swissprot;acc:q9nyq8]	FAT2	219.306	223.179	1.01766
1526	cadherin-related tumor suppressor homolog precursor (fat protein homolog). [swissprot;acc:q14517]	FAT
1527	mln64 n-terminal domain homolog (stard3 n-terminal like protein). [swissprot;acc:o95772]	STARD3NL
1528	hepatocyte nuclear factor 3-gamma (hnf-3g) (forkhead box protein a3) (fork head-related protein fkh h3). [swissprot;acc:p55318]	FOXA3	217.785	214.021	1.01759
1529	actin, cytoplasmic 2 (gamma-actin). [swissprot;acc:p02571]	ACTG1	216.762	213.031	1.01751
1530	af-6 protein. [swissprot;acc:p55196]	MLLT4	218.733	214.98	1.01746
1531	cysteine-rich motor neuron 1; cysteine-rich repeat-containing protein s52 precursor. [refseq;acc:nm_016441]	CRIM1	217.025	213.304	1.01744
1532	rna-binding protein 10 (rna binding motif protein 10) (dxs8237e). [swissprot;acc:p98175]	RBM10	228.419	232.376	1.01732
1533	cytochrome c. [swissprot;acc:p00001]	CYCS
1534	heparan sulfate 6-o-sulfotransferase 2. [refseq;acc:nm_147174]	HS6ST2
1535	heparan sulfate 6-o-sulfotransferase; heparan-sulfate 6-sulfotransferase. [refseq;acc:nm_004807]	HS6ST1
1536	fatty acid hydroxylase domain containing 1. [refseq;acc:nm_024306]	FA2H
1537	ww domain binding protein 11; npw38-binding protein npwbp; sh3 domain-binding protein snp70. [refseq;acc:nm_016312]	WBP11
1538	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]	ELAC2
1539	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]	RBM5
1540	autophagy protein 5-like (apg5-like) (apoptosis-specific protein). [swissprot;acc:q9h1y0]	ATG5	240.077	236.015	1.01721
1541	myb proto-oncogene protein (c-myb). [swissprot;acc:p10242]	MYB	222.672	218.92	1.01714
1542	trimethyllysine dioxygenase, mitochondrial precursor (ec 1.14.11.8) (epsilon-trimethyllysine 2-oxoglutarate dioxygenase) (tml-alpha- ketoglutarate dioxygenase) (tml hydroxylase) (tml dioxygenase) (tmld). [swissprot;acc:q9nvh6]	TMLHE	213.546	209.965	1.01706
1543	gtp-binding protein era homolog (hera) (fragment). [swissprot;acc:o75616]	ERAL1
1544	orphan nuclear receptor nr2e1 (nuclear receptor tlx) (tailless homolog) (tll) (htll). [swissprot;acc:q9y466]	NR2E1	219.762	216.081	1.01704
1545	orphan nuclear receptor tr2. [swissprot;acc:p13056]	NR2C1	219.76	216.083	1.01702
1546	argininosuccinate synthase (ec 6.3.4.5) (citrulline--aspartate ligase). [swissprot;acc:p00966]	ASS1	217.769	221.474	1.01701
1547	myb-related protein b (b-myb). [swissprot;acc:p10244]	MYBL2	222.541	218.823	1.01699
1548	myb-related protein a (a-myb). [swissprot;acc:p10243]	MYBL1	222.512	218.802	1.01696
1549	dynactin complex 50 kda subunit (50 kda dynein-associated polypeptide) (dynamitin) (dctn-50) (dynactin 2). [swissprot;acc:q13561]	DCTN2	225.159	221.424	1.01687
1550	adp,atp carrier protein, liver isoform t2 (adp/atp translocase 3) (adenine nucleotide translocator 3) (ant 3). [swissprot;acc:p12236]	SLC25A6
1551	adp,atp carrier protein, heart/skeletal muscle isoform t1 (adp/atp translocase 1) (adenine nucleotide translocator 1) (ant 1). [swissprot;acc:p12235]	SLC25A4
1552	adp,atp carrier protein, fibroblast isoform (adp/atp translocase 2) (adenine nucleotide translocator 2) (ant 2). [swissprot;acc:p05141]	SLC25A5
1553	adenosylhomocysteinase (ec 3.3.1.1) (s-adenosyl-l-homocysteine hydrolase) (adohcyase). [swissprot;acc:p23526]	AHCY	215.389	211.833	1.01679
1554	c-terminal binding protein 1 (ctbp1). [swissprot;acc:q13363]	CTBP1	196.215	193.018	1.01656
1555	pas domain containing serine/threonine kinase; pas-serine/threonine kinase. [refseq;acc:nm_015148]	PASK	196.192	192.996
1556	b-cell lymphoma 6 protein (bcl-6) (zinc finger protein 51) (laz-3 protein) (bcl-5). [swissprot;acc:p41182]	BCL6
1557	zinc finger protein slug (neural crest transcription factor slug) (snail homolog 2). [swissprot;acc:o43623]	SNAI2
1558	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]	CTBP2	196.171	192.977	1.01655
1559	b-cell cll/lymphoma 6, member b (zinc finger protein); zinc finger protein 62. [refseq;acc:nm_181844]	BCL6B	196.191	192.996
1560	p66 alpha. [refseq;acc:nm_017660]	GATAD2A	167.687	170.455	1.01651
1561	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	GATAD2B
1562	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	no value
1563	atp synthase gamma chain, mitochondrial precursor (ec 3.6.3.14). [swissprot;acc:p36542]	ATP5C1	218.277	214.739	1.01648
1564	atp synthase oligomycin sensitivity conferral protein, mitochondrial precursor (ec 3.6.3.14) (oscp). [swissprot;acc:p48047]	ATP5O
1565	eukaryotic translation initiation factor 3 subunit 11 (eif-3 p25) (eif3k) (muscle specific gene m9 protein) (ptd001) (hspc029) (arg134). [swissprot;acc:q9ubq5]	EIF3K	221.128	224.767	1.01646
1566	erythroid differentiation and denucleation factor 1. [swissprot;acc:o60584]	SLMO1
1567	bardet-biedl syndrome 7 protein isoform a; bbs2-like 1. [refseq;acc:nm_176824]	BBS7
1568	ba508n22.1 (hspc025) (fragment). [sptrembl;acc:q9hcw5]	no value
1569	lipopolysaccharide-responsive and beige-like anchor protein (cdc4-like protein) (beige-like protein). [swissprot;acc:p50851]
1570	protein c20orf45 (cgi-107). [swissprot;acc:q9y3b1]	SLMO2
1571	eukaryotic translation initiation factor 3 subunit 6 interacting protein (hspc021/hspc025). [swissprot;acc:q9y262]	EIF3EIP
1572	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]	RBM7
1573	r3h domain protein 1. [swissprot;acc:q15032]	R3HDM1	218.105	214.573
1574	tata element modulatory factor (tmf). [swissprot;acc:p82094]	TMF1	222.585	218.982	1.01645

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.