MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1513 to 1562 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	Network Comparison Type	red	network_comparison	green
190	AQP4	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	Squared	Divided	71389.9	1.34525	96037.6
	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kda subunit precursor (ec 2.4.1.119) (oligosaccharyl transferase 48 kda subunit) (ddost 48 kda subunit). [swissprot;acc:p39656]	Measured		4571.89	1.28281	5864.86
	FLAD1	fad synthetase. [refseq;acc:nm_025207]	Ranked	Subtracted	241.373	25.979	267.352
	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Rooted	Divided	149.165	1.15009	129.699
	MAPK11	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	Squared	Subtracted	42411.6	13390.5	55802.1
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Rooted		47.6504	10.72	36.9304
	SNRP70	u1 small nuclear ribonucleoprotein 70 kda (u1 snrnp 70 kda) (snrnp70) (u1-70k). [swissprot;acc:p08621]	Measured		4366.44	1533.32	5899.76
			Ranked	Divided	226.582	1.14179	198.444
191	no value	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 2 (paps synthethase 2) (papss 2) (sulfurylase kinase 2) (sk2) (sk 2) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o95340]		Subtracted	241.373	25.979	267.352
		filamin a (alpha-filamin) (filamin 1) (endothelial actin-binding protein) (abp-280) (nonmuscle filamin). [swissprot;acc:p21333]	Measured		4366.44	1533.32	5899.76
			Ranked	Divided	226.582	1.14179	198.444
	AQP5	aquaporin 5. [swissprot;acc:p55064]	Squared		71388.5	1.34525	96035.2
	ARAF	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	Rooted	Subtracted	116.797	10.686	106.111
	PLDN	pallidin; pallid (mouse) homolog, pallidin. [refseq;acc:nm_012388]		Divided	63.1192	1.14995	72.584
	SF3B1	splicing factor 3b subunit 1 (spliceosome associated protein 155) (sap 155) (sf3b155) (pre-mrna splicing factor sf3b 155 kda subunit). [swissprot;acc:o75533]	Measured		4638.1	1.27712	5923.4
	SPHK1	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Squared	Subtracted	42411.6	13390.5	55802.1
192	no value	small glutamine rich protein with tetratricopeptide repeats 2. [refseq;acc:nm_019072]	Measured		10807.4	1531.1	12338.5
	AQP2	aquaporin-cd (aqp-cd) (water channel protein for renal collecting duct) (adh water channel) (aquaporin 2) (collecting duct water channel protein) (wch-cd). [swissprot;acc:p41181]	Squared	Divided	71387.4	1.34524	96033.4
	ARAF	a-raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (a-raf-1) (proto-oncogene pks). [swissprot;acc:p10398]	Measured		17757.5	1.26767	14008
	DPAGT1	udp-n-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase (ec 2.7.8.15) (gpt) (g1pt) (n-acetylglucosamine-1-phosphate transferase) (glcnac-1-p transferase). [swissprot;acc:q9h3h5]	Squared	Subtracted	42411.6	13390.5	55802.1
	LGTN	ligatin (hepatocellular carcinoma-associated antigen 56). [swissprot;acc:p41214]	Ranked		241.373	25.979	267.352
	MSI2	musashi 2 isoform a. [refseq;acc:nm_138962]		Divided	227.491	1.14055	199.458
	RAF1	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Rooted	Subtracted	116.792	10.685	106.107
	SF4	splicing factor 4 isoform b; rna-binding protein. [refseq;acc:nm_021164]		Divided	53.6107	1.14877	61.5862
193	DLC1	rho-gtpase-activating protein 7 (rho-type gtpase-activating protein 7) (deleted in liver cancer 1 protein) (dlc-1) (hp protein) (star-related lipid transfer protein 12) (stard12) (start domain-containing protein 12). [swissprot;acc:q96qb1]	Squared	Subtracted	42411.6	13390.5	55802.1
	MIP	lens fiber major intrinsic protein (mip26) (mp26) (aquaporin 0). [swissprot;acc:p30301]		Divided	71386.9	1.34524	96032.5
	MSI1	musashi 1. [refseq;acc:nm_002442]	Ranked		227.491	1.14055	199.458
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Rooted		59.6399	1.1486	51.9242
	PAPSS1	bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthethase 1 (paps synthethase 1) (papss 1) (sulfurylase kinase 1) (sk1) (sk 1) [includes: sulfate adenylyltransferase (ec 2.7.7.4) (sulfate adenylate transferase) (sat) (atp-sulfurylase); adenylylsulfate kinase (ec 2.7.1.25) (adenylylsulfate 3'-phosphotransferase) (aps kinase) (adenosine-5'-phosphosulfate 3'-phosphotransferase) (3'- phosphoadenosine-5'-phosphosulfate synthetase)]. [swissprot;acc:o43252]	Ranked	Subtracted	241.373	25.979	267.352
	PPP2R1A	serine/threonine protein phosphatase 2a, 65 kda regulatory subunit a, alpha isoform (pp2a, subunit a, pr65-alpha isoform) (pp2a, subunit a, r1-alpha isoform) (medium tumor antigen-associated 61 kda protein). [swissprot;acc:p30153]	Measured		4612.39	1518.79	3093.6
	PPP2R5E	serine/threonine protein phosphatase 2a, 56 kda regulatory subunit, epsilon isoform (pp2a, b subunit, b' epsilon isoform) (pp2a, b subunit, b56 epsilon isoform) (pp2a, b subunit, pr61 epsilon isoform) (pp2a, b subunit, r5 epsilon isoform). [swissprot;acc:q16537]	Rooted		116.707	10.663	106.044
	RAF1	raf proto-oncogene serine/threonine-protein kinase (ec 2.7.1.-) (raf-1) (c-raf). [swissprot;acc:p04049]	Measured	Divided	17756.5	1.26766	14007.3
194	AQP1	aquaporin-chip (water channel protein for red blood cells and kidney proximal tubule) (aquaporin 1) (aqp-1) (urine water channel). [swissprot;acc:p29972]	Squared		71346.6	1.34505	95965.1
	CCNG2	cyclin g2. [swissprot;acc:q16589]	Measured		17738.6	1.26743	13995.7
			Rooted	Subtracted	116.707	10.663	106.044
	MAPKAPK2	map kinase-activated protein kinase 2 (ec 2.7.1.-) (mapk-activated protein kinase 2) (mapkap kinase 2) (mapkapk-2). [swissprot;acc:p49137]	Squared		42411.6	13390.5	55802.1
	POR	nadph-cytochrome p450 reductase (ec 1.6.2.4) (cpr) (p450r). [swissprot;acc:p16435]	Ranked		241.373	25.979	267.352
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]	Measured		4300.47	1507.25	5807.72
	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Rooted	Divided	59.6399	1.1486	51.9242
	ZC3H14	nuclear protein ukp68. [refseq;acc:nm_024824]	Ranked		227.491	1.14055	199.458
195	CCNG1	cyclin g1 (cyclin g). [swissprot;acc:p51959]	Measured		17738.5	1.26743	13995.6
			Rooted	Subtracted	116.707	10.663	106.044
	CHRNA6	neuronal acetylcholine receptor protein, alpha-6 chain precursor. [swissprot;acc:q15825]	Squared		42411.6	13390.5	55802.1
	PCYT1B	cholinephosphate cytidylyltransferase b (ec 2.7.7.15) (phosphorylcholine transferase b) (ctp:phosphocholine cytidylyltransferase b) (ct b) (cct b) (cct-beta). [swissprot;acc:q9y5k3]	Ranked		241.373	25.979	267.352
	PRPF40B	huntingtin interacting protein c. [refseq;acc:nm_012272]		Divided	227.971	1.13748	200.417
	SLC39A6	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	Rooted		59.6399	1.1486	51.9242
	SSR4	translocon-associated protein, delta subunit precursor (trap-delta) (signal sequence receptor delta subunit) (ssr-delta). [swissprot;acc:p51571]	Squared		71062.4	1.34373	95488.9
	UFC1	protein cgi-126 (protein hspc155). [swissprot;acc:q9y3c8]	Measured	Subtracted	3074.57	1492.94	4567.51
196	no value	hpaii tiny fragments locus 9c. [refseq;acc:nm_022727]	Ranked		272.781	25.889	246.892
	AQP4	aquaporin 4 (wch4) (mercurial-insensitive water channel) (miwc). [swissprot;acc:p55087]	Measured		10640.2	1477.6	12117.8

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.