MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1463 to 1512 of 66312 in total

Filtered  : 1

Rank	Hugo	description	Value Type	Network Comparison Type	Interaction Map	red	network_comparison	green
92	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]	Ranked	Subtracted	High confidence	249.663	48.6	298.263
	HRAS	transforming protein p21/h-ras-1 (c-h-ras). [swissprot;acc:p01112]	Squared			105473	41340.7	64132.3
	MAGEB4	melanoma-associated antigen b1 (mage-b1 antigen) (mage-xp antigen) (dss-ahc critical interval mage superfamily 10) (dam10). [swissprot;acc:p43366]	Measured		Low confidence	11285.3	966.8	10318.5
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Ranked	Divided	High confidence	88.2482	1.24949	110.265
	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	Measured			4117.67	1.40882	5801.04
	PITRM1	metalloprotease 1; metalloprotease 1 (pitrilysin family). [refseq;acc:nm_014889]	Squared			29570.7	1.58967	18601.8
	PSEN1	presenilin 1 (ps-1) (s182 protein). [swissprot;acc:p49768]	Rooted			37.3005	1.29795	48.4141
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]		Subtracted	Low confidence	98.1106	6.6074	104.718
	VPS33A	vacuolar protein sorting 33a (hvps33a). [swissprot;acc:q96ax1]	Measured	Divided		7297.57	1.10322	8050.82
	ZFAND5	zinc finger protein 216. [swissprot;acc:o76080]	Squared	Subtracted		79152.9	9319.8	69833.1
93	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	Measured	Divided	High confidence	4245.52	1.39977	5942.75
		transforming protein n-ras. [swissprot;acc:p01111]	Squared	Subtracted		105469	41338.8	64130.2
	ALG1	beta-1,4 mannosyltransferase. [refseq;acc:nm_019109]		Divided		29567	1.58949	18601.6
	BEST2	vitelliform macular dystrophy 2-like protein 1. [refseq;acc:nm_017682]	Rooted		Low confidence	186.878	1.09193	204.057
	CUL1	cullin homolog 1 (cul-1). [swissprot;acc:q13616]			High confidence	37.3005	1.29795	48.4141
	CXorf9	chromosome x open reading frame 9; likely ortholog of mouse sh3 gene sly. [refseq;acc:nm_018990]	Squared		Low confidence	55143.2	1.18308	46609.7
	DAB2IP	dab2 interacting protein; ngap-like protein; doc-2/dab2 interactive protein. [refseq;acc:nm_032552]	Ranked			247.334	1.08082	228.84
	E2F2	transcription factor e2f2 (e2f-2). [swissprot;acc:q14209]		Subtracted		220.497	15.133	205.364
	GNAZ	guanine nucleotide-binding protein g(z), alpha subunit (g(x) alpha chain) (gz-alpha). [swissprot;acc:p19086]	Rooted		High confidence	40.2805	15.9115	24.369
	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Ranked	Divided		88.2482	1.24949	110.265
	MAGED2	melanoma-associated antigen d2 (mage-d2 antigen) (breast cancer associated gene 1 protein) (bcg-1) (11b6) (hepatocellular carcinoma associated protein jcl-1). [swissprot;acc:q9unf1]	Measured	Subtracted	Low confidence	11285.3	966.8	10318.5
	RBM7	putative rna-binding protein 7 (rna binding motif protein 7). [swissprot;acc:q9y580]		Divided		4616.06	1.103	5091.51
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Ranked	Subtracted	High confidence	249.663	48.6	298.263
	SEPT6	septin 6. [swissprot;acc:q14141]	Rooted		Low confidence	97.7187	6.5443	104.263
	ZFAND6	protein associated with prk1. [refseq;acc:nm_019006]	Squared			79152.9	9319.8	69833.1
	ZNF547	sedlin. [swissprot;acc:o14582]	Measured		High confidence	17396.9	3087	20483.9
94	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]		Divided		4247.86	1.39879	5941.88
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Ranked			88.2482	1.24949	110.265
		synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	Measured	Subtracted		17396.9	3087	20483.9
	ADIPOR2	adiponectin receptor 2. [refseq;acc:nm_024551]	Ranked		Low confidence	219.277	15.065	204.212
	CHRAC1	chromatin accessibility complex protein 1 (chrac-1) (chrac-15) (huchrac15) (dna polymerase epsilon subunit p15). [swissprot;acc:q9nrg0]	Measured	Divided		5674.92	1.10225	6255.18
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Ranked	Subtracted	High confidence	249.663	48.6	298.263
	GNAT1	guanine nucleotide-binding protein g(t), alpha-1 subunit (transducin alpha-1 chain). [swissprot;acc:p11488]	Rooted			40.2805	15.9114	24.3691
	OPHN1	oligophrenin 1. [swissprot;acc:o60890]		Divided	Low confidence	61.0103	1.0913	66.5804
	PHF12	phd finger protein 12; phd zinc finger transcription factor. [refseq;acc:nm_020889]	Squared	Subtracted		61253.4	9275.6	51977.8
	PPP1R13B	protein phosphatase 1, regulatory (inhibitor) subunit 13b; apoptosis-stimulating protein of p53, 1. [refseq;acc:nm_015316]			High confidence	124319	37470.8	86848.2
	RASAL2	ras gtpase-activating protein ngap (ras protein activator like 1). [swissprot;acc:q9ujf2]	Ranked	Divided	Low confidence	247.087	1.08043	228.693
	RBM15B	chromosome 3p21.1 gene sequence. [refseq;acc:nm_013286]	Rooted		High confidence	47.6504	1.29028	36.9304
	RGL1	ral guanine nucleotide dissociation stimulator-like 1 (ralgds-like 1). [swissprot;acc:q9nzl6]	Squared			84857.8	1.58903	53402.4
	SAMSN1	sam-domain protein samsn-1 (sam domain, sh3 domain and nuclear localisation signals protein 1). [swissprot;acc:q9nsi8]			Low confidence	55150.3	1.1825	46638.9
	T	brachyury protein (t protein). [swissprot;acc:o15178]	Rooted	Subtracted		61.687	6.5133	68.2003
	TRO	trophinin. [swissprot;acc:q12816]	Measured			11285.3	966.8	10318.5
95	ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]	Rooted	Divided		61.0916	1.09075	66.6358
	CPEB3	cytoplasmic polyadenylation element binding protein 3. [refseq;acc:nm_014912]	Measured			4626.46	1.1021	5098.83
	GNAT2	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	Rooted	Subtracted	High confidence	40.2804	15.9112	24.3692
	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Ranked	Divided		88.2482	1.24949	110.265
	OTC	ornithine carbamoyltransferase, mitochondrial precursor (ec 2.1.3.3) (otcase) (ornithine transcarbamylase). [swissprot;acc:p00480]	Measured	Subtracted	Low confidence	10803	954.7	11757.7
	PPP1R7	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	Squared	Divided	High confidence	256169	1.57626	162517
	RAB37	ras-related protein rab-37. [swissprot;acc:q96ax2]		Subtracted	Low confidence	61163.4	9239.4	51924
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Ranked		High confidence	249.663	48.6	298.263

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.