MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 147 to 196 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Value Type	red	green	network_comparison
37	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	PANK2	Squared	106226	192141	1.80879
	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]	PPP1R14A	Ranked	322	253	1.27273
38	guanine nucleotide-binding protein g(t), alpha-2 subunit (transducin alpha-2 chain). [swissprot;acc:p19087]	GNAT2	Measured	1836.76	907.774	2.02337
			Rooted	40.2804	24.3692	1.65292
	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	MFAP4	Ranked	322	253	1.27273
	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	PANK3	Squared	106226	192141	1.80879
39	guanine nucleotide-binding protein g(i), alpha-2 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04899]	GNAI2	Measured	1836.8	907.903	2.02312
			Rooted	40.28	24.37	1.65285
	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	SLC25A43	Squared	106226	192141	1.80879
	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	PPP1R14D	Ranked	322	253	1.27273
40	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]	ATG4A	Squared	144940	81169.7	1.78564
	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	FCN2	Ranked	322	253	1.27273
	guanine nucleotide-binding protein g(i), alpha-1 subunit (adenylate cyclase-inhibiting g alpha protein). [swissprot;acc:p04898]	GNAI1	Measured	1836.81	907.978	2.02297
			Rooted	40.2797	24.3705	1.65281
41	guanine nucleotide-binding protein g(k), alpha subunit (g(i) alpha-3). [swissprot;acc:p08754]	GNAI3	Measured	1836.81	907.978	2.02297
			Rooted	40.2797	24.3705	1.65281
	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]	MAP1LC3B	Squared	144912	81155	1.78562
	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	no value	Ranked	322	253	1.27273
42	guanine nucleotide-binding protein beta subunit 5 (transducin beta chain 5). [swissprot;acc:o14775]	GNB5	Measured	1857.32	958.237	1.93827
			Rooted	40.225	24.7051	1.62821
	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]	MAP1LC3A	Squared	144911	81154.7	1.78561
	proto-oncogene protein c-fos (cellular oncogene fos) (g0/g1 switch regulatory protein 7). [swissprot;acc:p01100]	FOS	Ranked	204.641	160.957	1.2714
43	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	ATG4B	Squared	144876	81136.5	1.78558
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1	Rooted	40.6302	25.4452	1.59677
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Measured	1881.02	1027.36	1.83093
	jun dimerization protein. [refseq;acc:nm_130469]	no value	Ranked	204.641	160.957	1.2714
44	fos-related antigen 2. [swissprot;acc:p15408]	FOSL2			161.046	1.2707
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	GABARAP	Squared	139741	78454.6	1.78117
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Rooted	40.5691	25.4263	1.59556
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 1 (transducin beta chain 1). [swissprot;acc:p04901]	GNB1	Measured	1931.34	1057.39	1.82652
45	gaba-a receptor-associated protein. [sptrembl;acc:q9by60]	no value	Squared	129597	73157.5	1.77148
	guanine nucleotide-binding protein beta subunit 4 (transducin beta chain 4). [swissprot;acc:q9hav0]	GNB4	Measured	1926.69	1056.02	1.82448
	guanine nucleotide-binding protein g(i)/g(s)/g(t) beta subunit 3 (transducin beta chain 3). [swissprot;acc:p16520]	GNB3	Rooted	40.081	25.1546	1.59339
	protein fosb (g0/g1 switch regulatory protein 3). [swissprot;acc:p53539]	FOSB	Ranked	204.641	161.051	1.27066
46	apg3p; pc3-96 protein. [refseq;acc:nm_022488]	ATG3	Squared	129597	73157.5	1.77148
	deltex 2. [refseq;acc:nm_020892]	DTX2	Rooted	27.634	43.9629	1.5909
	fos-related antigen 1 (fra-1). [swissprot;acc:p15407]	FOSL1	Ranked	204.642	161.068	1.27053
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	NEUROD2	Measured	779.167	1390.33	1.78438
47	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3
	deltex homolog 1; hdx-1. [refseq;acc:nm_004416]	DTX1	Rooted	27.7078	44.017	1.58861
	gbp protein isoform a. [refseq;acc:nm_017870]	TMEM132A	Ranked	325.586	256.492	1.26938
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	no value	Squared	98517.9	56927.2	1.73059
48	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	Measured	779.167	1390.33	1.78438
	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	GABARAP	Ranked	65.4586	83.0461	1.26868
	lag1 longevity assurance homolog 2 isoform 1; l3 pigment; tumor metastasis-suppressor. [refseq;acc:nm_022075]	LASS2	Squared	6300.2	10703.5	1.69891
	t-lak cell-originated protein kinase; spermatogenesis-related protein kinase; pdz-binding kinase; pbk; mapkk-like protein kinase; serine/threonine protein kinase. [refseq;acc:nm_018492]	PBK	Rooted	27.7254	44.0299	1.58807
49	associated molecule with the sh3 domain of stam (amsh) like protein. [refseq;acc:nm_020799]	STAMBPL1	Squared	28994.2	17134.8	1.69212
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2	Ranked	133	105	1.26667
	kh domain containing, rna binding, signal transduction associated 3; sam68-like phosphotyrosine protein, t-star. [refseq;acc:nm_006558]	KHDRBS3	Rooted	27.7254	44.0299	1.58807
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	Measured	779.167	1390.33	1.78438

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.