MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	network_comparison	green
729	no value	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	Subtracted	208.874	10.834	219.708
730	TIMM10	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	Divided		1.05187
			Subtracted		10.834
731	FH	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	Divided		1.05187
			Subtracted		10.834
732	no value	translin. [swissprot;acc:q15631]		224.385	10.746	235.131
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Divided	124.434	1.05169	118.318
733	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]		164	1.05154	155.961
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	Subtracted	224.385	10.746	235.131
734	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	Divided	232.601	1.0513	244.534
	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Subtracted	224.385	10.746	235.131
735	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]		229.045	10.702	218.343
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Divided	232.601	1.0513	244.534
736	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	N6AMT1	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	Subtracted	228.78	10.689	218.091
737	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]		221.968	10.642	211.326
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Divided	125.526	1.05129	119.402
738	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]	Subtracted	222.138	10.635	211.503
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Divided	222.825	1.05123	211.966
739	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Subtracted	272.878	10.594	283.472
	PFAS	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Divided	223.58	1.0512	235.027
740	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Subtracted	223.463	10.588	212.875
	ATIC	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	Divided	223.58	1.0512	235.027
741	PAICS	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]
	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]	Subtracted	223.463	10.588	212.875
742	no value	histone deacetylase 2 (hd2). [swissprot;acc:q92769]		226.003	10.462	215.541
	BRP44	brain protein 44. [swissprot;acc:o95563]	Divided	126.215	1.05111	120.078
743	MCFD2	multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	Subtracted	225.996	10.461	215.535
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Divided	126.215	1.05111	120.078
744	no value	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	Subtracted	225.996	10.461	215.535
	SEPT6	septin 6. [swissprot;acc:q14141]	Divided	126.604	1.05098	120.463
745	HDAC1	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	Subtracted	225.989	10.459	215.53
	SLC35B1	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	Divided	214.679	1.05072	225.568
746	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]		250.465	1.0507	238.38
	TRIOBP	protein tara (trio-associated repeat on actin) (hrihfb2122). [swissprot;acc:q9h2d6]	Subtracted	213.804	10.422	224.226
747	no value	rho interacting protein 3. [refseq;acc:nm_015134]		213.803	10.421	224.224
		trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Divided	250.465	1.0507	238.38
748	FBL	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]		245.246	1.05038	233.483
	PRPF3	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Subtracted	222.082	10.375	211.707
749	DNAJB4	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]		210.946	10.279	221.225
	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	Divided	221.968	1.05036	211.326
750	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]		222.138	1.05028	211.503
	PERLD1	cab2. [refseq;acc:nm_033419]	Subtracted	210.946	10.279	221.225
751	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Divided	223.463	1.04974	212.875
	DNAJB5	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]	Subtracted	210.946	10.279	221.225
752	DNAJB1	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]
	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]	Divided	223.463	1.04974	212.875
753	ETF1	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	Subtracted	210.946	10.279	221.225
	LBP	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	Divided	224.434	1.04968	235.583
754	SPCS2	microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.