MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Network Comparison Type	red	Gene	Rank	Hugo	Value Type	network_comparison	Interaction Map	Filtered	green

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 2060 in total

Network Comparison Type  : Subtracted
red  : 0
network_comparison  : 0
Interaction Map  : High confidence
Filtered  : 1
green  : 0

description	Rank	Hugo	Value Type
schwannomin interacting protein 1. [refseq;acc:nm_014575]	2900	SCHIP1	Ranked
			Squared
			Rooted
sec23-interacting protein p125; phospholipase. [refseq;acc:nm_007190]	3097	SEC23IP	Measured
			Ranked
			Squared
			Rooted
semaphorin 6b precursor (semaphorin z) (sema z). [swissprot;acc:q9h3t3]	2832	SEMA6B	Measured
			Ranked
			Squared
			Rooted
semaphorin 6c precursor (semaphorin y) (sema y). [swissprot;acc:q9h3t2]	2933	SEMA6C	Measured
			Ranked
			Squared
			Rooted
semaphorin 6d isoform 3 precursor. [refseq;acc:nm_153617]	2964	SEMA6D	Measured
			Ranked
			Squared
			Rooted
sentrin-specific protease 8 (ec 3.4.22.-) (sentrin/sumo-specific protease senp8) (cysteine protease fksg8). [swissprot;acc:q96ld8]	2843	SENP8	Measured
			Ranked
			Squared
			Rooted
serine/threonine kinase 38 like. [refseq;acc:nm_015000]	2897	no value	Measured
			Ranked
			Squared
			Rooted
serine/threonine kinase 38; serine threonine protein kinase. [refseq;acc:nm_007271]	3071	STK38	Measured
			Ranked
			Squared
			Rooted
serine/threonine protein kinase 24 (ec 2.7.1.37) (ste20-like kinase mst3) (mst-3) (mammalian ste20-like protein kinase 3). [swissprot;acc:q9y6e0]	3115	STK24	Measured
			Ranked
			Squared
			Rooted
serine/threonine protein kinase 25 (ec 2.7.1.37) (sterile 20/oxidant stress-response kinase 1) (ste20/oxidant stress response kinase-1) (sok-1) (ste20-like kinase). [swissprot;acc:o00506]	3048	STK25	Measured
			Ranked
			Squared
			Rooted
serine/threonine protein kinase 3 (ec 2.7.1.37) (ste20-like kinase mst2) (mst-2) (mammalian ste20-like protein kinase 2) (serine/threonine protein kinase krs-1). [swissprot;acc:q13188]	3111	STK3	Measured
			Ranked
			Squared
			Rooted
serine/threonine protein kinase mask; ste20-like kinase mst4. [refseq;acc:nm_016542]	2982	no value	Measured
			Ranked
			Squared
			Rooted
serine/threonine-protein kinase chk1 (ec 2.7.1.-). [swissprot;acc:o14757]	2908	CHEK1	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.