MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Network Comparison Type	Rank	Gene	Hugo	description	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 1892 in total

Network Comparison Type  : Subtracted
Interaction Map  : High confidence
Filtered  : 1
red  : 0
network_comparison  : 0
green  : 0

Rank	Hugo	description	Value Type
3120	SCML2	sex comb on midleg-like 2; sex comb on midleg like 2. [refseq;acc:nm_006089]	Ranked
			Squared
			Rooted
3121	GLRA2	glycine receptor alpha-2 chain precursor. [swissprot;acc:p23416]	Measured
			Ranked
			Squared
			Rooted
3122	PRPS2	ribose-phosphate pyrophosphokinase ii (ec 2.7.6.1) (phosphoribosyl pyrophosphate synthetase ii) (ppribp) (prs-ii). [swissprot;acc:p11908]	Measured
			Ranked
			Squared
			Rooted
3123	VAPA	vesicle-associated membrane protein-associated protein a (vamp- associated protein a) (vamp-a) (vap-a) (33 kda vamp-associated protein) (vap-33). [swissprot;acc:q9p0l0]	Measured
			Ranked
			Squared
			Rooted
3124	SAMHD1	sam domain and hd domain-containing protein 1 (dendritic cell-derived ifng-induced protein) (dcip) (monocyte protein 5) (mop-5). [swissprot;acc:q9y3z3]	Measured
			Ranked
			Squared
			Rooted
3125	POFUT1	gdp-fucose protein o-fucosyltransferase 1 precursor (ec 2.4.1.221) (peptide o-fucosyltransferase) (o-fuct-1). [swissprot;acc:q9h488]	Measured
			Ranked
			Squared
			Rooted
3126	PLCB4	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (ec 3.1.4.11) (phosphoinositide phospholipase c) (plc-beta-4) (phospholipase c-beta-4). [swissprot;acc:q15147]	Measured
			Ranked
			Squared
			Rooted
3127	SEC23B	protein transport protein sec23b (sec23-related protein b). [swissprot;acc:q15437]	Measured
			Ranked
			Squared
			Rooted
3128	BMP7	bone morphogenetic protein 7 precursor (bmp-7) (osteogenic protein 1) (op-1). [swissprot;acc:p18075]	Measured
			Ranked
			Squared
			Rooted
3129	CSTF1	cleavage stimulation factor, 50 kda subunit (cstf 50 kda subunit) (cf-1 50 kda subunit). [swissprot;acc:q05048]	Measured
			Ranked
			Squared
			Rooted
3130	PFDN4	prefoldin subunit 4 (protein c-1). [swissprot;acc:q9nqp4]	Measured
			Ranked
			Squared
			Rooted
3131	C20orf24	protein c20orf24 (rab5-interacting protein) (rip5) (pnas-11). [swissprot;acc:q9buv8]	Measured
			Ranked
			Squared
			Rooted
3132	R3HDML	r3h domain (binds single-stranded nucleic acids) containing-like. [refseq;acc:nm_178491]	Measured
			Ranked
			Squared

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.