MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 16578 in total

Value Type  : Ranked
Filtered  : 1

Rank	Network Comparison Type	Hugo	description	Interaction Map	red	network_comparison	green
365	Divided	SPAG7	sperm associated antigen 7. [refseq;acc:nm_004890]	Low confidence	117.525	1.03773	121.959
	Subtracted	CHDH	choline dehydrogenase. [refseq;acc:nm_018397]		204.231	7.458	196.773
		FCER2	low affinity immunoglobulin epsilon fc receptor (lymphocyte ige receptor) (fc-epsilon-rii) (cd23) (blast-2) (immunoglobulin e-binding factor). [swissprot;acc:p06734]	High confidence	233.539	19.658	253.197
366	Divided	RPS5	40s ribosomal protein s5. [swissprot;acc:p46782]		242.473	1.09602	265.756
		ZMIZ1	retinoic acid induced 17; pias-like protein hzimp10. [refseq;acc:nm_020338]	Low confidence	207.433	1.03746	199.944
	Subtracted	CD209	cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	High confidence	233.539	19.658	253.197
		SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Low confidence	206.945	7.442	199.503
367	Divided	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	High confidence	234.146	1.09601	256.627
		SORBS1	ponsin; sh3-domain protein 5 (ponsin). [refseq;acc:nm_015385]	Low confidence	206.945	1.0373	199.503
	Subtracted	DPP9	dipeptidylpeptidase 9; dipeptidyl peptidase 9; dipeptidyl peptidase iv-related protein-2. [refseq;acc:nm_139159]	High confidence	218.827	19.58	238.407
		SF3A3	splicing factor 3a subunit 3 (spliceosome associated protein 61) (sap 61) (sf3a60). [swissprot;acc:q12874]	Low confidence	202.387	7.438	194.949
368	Divided	PUS1	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	High confidence	242.66	1.09501	265.715
		SPSB4	spry domain-containing socs box protein ssb-4. [refseq;acc:nm_080862]	Low confidence	219.655	1.03727	211.763
	Subtracted	DPP8	dipeptidyl peptidase 8 isoform 2; dipeptidyl peptidase 8. [refseq;acc:nm_017743]	High confidence	218.827	19.58	238.407
		SF3A1	splicing factor 3 subunit 1 (spliceosome associated protein 114) (sap 114) (sf3a120). [swissprot;acc:q15459]	Low confidence	202.387	7.438	194.949
369	Divided	MRPL12	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	High confidence	242.159	1.09475	265.104
		MXD1	mad protein (max dimerizer). [swissprot;acc:q05195]	Low confidence	205.943	1.03721	198.554
	Subtracted					7.389
		POLR2E	dna-directed rna polymerase ii 23 kda polypeptide (ec 2.7.7.6) (rpb25) (xap4) (rpb5) (rpabc1). [swissprot;acc:p19388]	High confidence	239.977	19.548	259.525
370	Divided	AFF1	af-4 protein (proto-oncogene af4) (fel protein). [swissprot;acc:p51825]	Low confidence	219.597	1.0372	211.722
		NUDT12	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	High confidence	242.159	1.09475	265.104
	Subtracted	ITGB1BP3	muscle-specific beta 1 integrin binding protein. [refseq;acc:nm_014446]		218.818	19.54	238.358
		LDHAL6B	l-lactate dehydrogenase a-like (ec 1.1.1.27). [swissprot;acc:q9byz2]	Low confidence	205.928	7.374	198.554
371	Divided	AFF2	fragile x mental retardation 2 protein (protein fmr-2) (fmr2p) (ox19 protein) (fragile x e mental retardation syndrome protein). [swissprot;acc:p51816]		219.599	1.0372	211.723
		RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	High confidence	186.52	1.09447	170.42
	Subtracted	LDHC	l-lactate dehydrogenase c chain (ec 1.1.1.27) (ldh-c) (ldh testis subunit) (ldh-x). [swissprot;acc:p07864]	Low confidence	205.928	7.374	198.554
		SLC15A1	oligopeptide transporter, small intestine isoform (peptide transporter 1) (intestinal h+/peptide cotransporter) (solute carrier family 15, member 1). [swissprot;acc:p46059]	High confidence	186.172	19.511	166.661
372	Divided	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]		186.52	1.09447	170.42
		AFF3	laf-4 protein (lymphoid nuclear protein related to af4). [swissprot;acc:p51826]	Low confidence	219.598	1.0372	211.722
	Subtracted	LDHA	l-lactate dehydrogenase a chain (ec 1.1.1.27) (ldh-a) (ldh muscle subunit) (ldh-m). [swissprot;acc:p00338]		205.928	7.374	198.554
		POLR3G	polymerase (rna) iii (dna directed) (32kd). [refseq;acc:nm_006467]	High confidence	239.709	19.329	259.038
373	Divided	AFF4	all1 fused gene from 5q31. [refseq;acc:nm_014423]	Low confidence	219.598	1.0372	211.722
		MRPL11	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	High confidence	242.37	1.09442	265.255
	Subtracted	DCTN5	dynactin 4. [refseq;acc:nm_032486]		233.142	19.111	252.253
		LDHB	l-lactate dehydrogenase b chain (ec 1.1.1.27) (ldh-b) (ldh heart subunit) (ldh-h). [swissprot;acc:p07195]	Low confidence	205.928	7.374	198.554
374	Divided	PGBD3	excision repair protein ercc-6 (cockayne syndrome protein csb). [swissprot;acc:q03468]		210.34	1.03719	202.797
		TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	High confidence	267.208	1.09436	244.168
	Subtracted	CHRNA7	neuronal acetylcholine receptor protein, alpha-7 chain precursor. [swissprot;acc:p36544]		248.152	19.074	267.226
		CLASP1	clip-associating protein 1; drosophila 'multiple asters' (mast)-like homolog 1. [refseq;acc:nm_015282]	Low confidence	205.928	7.374	198.554
375	Divided	POLR3A	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	High confidence	242.686	1.09407	265.516
		SPSB1	spry domain-containing socs box protein ssb-1. [refseq;acc:nm_025106]	Low confidence	219.556	1.03715	211.692
	Subtracted	ADCY6	adenylate cyclase, type vi (ec 4.6.1.1) (atp pyrophosphate-lyase) (ca(2+)-inhibitable adenylyl cyclase). [swissprot;acc:o43306]	High confidence	248.152	19.074	267.226
		MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	Low confidence	205.926	7.372	198.554
376	Divided	CCRN4L	nocturnin (ccr4 protein homolog). [swissprot;acc:q9uk39]		209.328	1.03715	201.83
		DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	High confidence	257.017	1.09395	234.945
	Subtracted	ADCY5	adenylate cyclase, type v (ec 4.6.1.1) (atp pyrophosphate-lyase) (adenylyl cyclase) (fragment). [swissprot;acc:o95622]		248.152	19.074	267.226
		TREX2	x-linked protein sts1769. [swissprot;acc:q99871]	Low confidence	211.253	7.37	203.883
377	Divided	LDHAL6B	l-lactate dehydrogenase a-like (ec 1.1.1.27). [swissprot;acc:q9byz2]		205.928	1.03714	198.554
		POLR1A	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	High confidence	242.691	1.09391	265.481
	Subtracted	ATRIP	three prime repair exonuclease 1 isoform c; deoxyribonuclease iii, dnaq/mutd (e. coli)-like; 3' repair exonuclease 1; atr interacting protein. [refseq;acc:nm_032166]	Low confidence	211.253	7.37	203.883

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.