MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Value Type	red	green	network_comparison
365	CAPS	calcyphosine. [swissprot;acc:q13938]	Measured	5189	6088.47	1.17334
	MRPL36	60s ribosomal protein l36, mitochondrial precursor (l36mt) (brca1- interacting protein 1). [swissprot;acc:q9p0j6]	Ranked	242.744	266.07	1.09609
	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	Rooted	49.7541	54.9425	1.10428
366	BHLHB4	ba305p22.3 (breast carcinoma amplified sequence 4). [sptrembl;acc:q8ndy6]	Squared	62783.5	50784.1	1.23628
	CRNKL1	crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	Measured	5189	6088.47	1.17334
	RPS15A	40s ribosomal protein s15a. [swissprot;acc:p39027]	Rooted	50.5463	45.7763	1.1042
	RPS5	40s ribosomal protein s5. [swissprot;acc:p46782]	Ranked	242.473	265.756	1.09602
367	BHLHB5	basic helix-loop-helix domain containing, class b, 5; trinucleotide repeat containing 20. [refseq;acc:nm_152414]	Squared	62757.7	50767.8	1.23617
	DDX18	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	Rooted	49.0882	54.2027	1.10419
	HNRPM	heterogeneous nuclear ribonucleoprotein m (hnrnp m). [swissprot;acc:p52272]	Ranked	234.146	256.627	1.09601
	POLE	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Measured	4024.4	4719.35	1.17268
368	CDC40	pre-mrna splicing factor prp17 (hprp17) (eh-binding protein 3) (ehb3). [swissprot;acc:o60508]		5082.66	5959.99	1.17261
	DRAP1	dr1-associated protein 1; negative cofactor 2 alpha; dr1-associated corepressor. [refseq;acc:nm_006442]	Squared	51805.2	41916.4	1.23592
	PUS1	trna pseudouridine synthase a (ec 4.2.1.70) (pseudouridylate synthase i) (pseudouridine synthase i) (uracil hydrolyase). [swissprot;acc:q9y606]	Ranked	242.66	265.715	1.09501
	RRP1	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	Rooted	49.5225	54.6817	1.10418
369	CEBPZ	ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	Measured	3583.56	4194.95	1.17061
	LGALS9	galectin-9 (hom-hd-21) (ecalectin). [swissprot;acc:o00182]	Squared	45960.8	56749.6	1.23474
	METAP1	methionine aminopeptidase 1 (ec 3.4.11.18) (metap 1) (map 1) (peptidase m 1). [swissprot;acc:p53582]	Rooted	49.7435	45.0586	1.10397
	MRPL12	60s ribosomal protein l12, mitochondrial precursor (l12mt) (5c5-2). [swissprot;acc:p52815]	Ranked	242.159	265.104	1.09475
370	EPB41	protein 4.1 (band 4.1) (p4.1) (epb4.1) (4.1r). [swissprot;acc:p11171]	Squared	45986	56776.1	1.23464
	METAP2	methionine aminopeptidase 2 (ec 3.4.11.18) (metap 2) (peptidase m 2) (initiation factor 2 associated 67 kda glycoprotein) (p67) (p67eif2). [swissprot;acc:p50579]	Rooted	49.7435	45.0586	1.10397
	NUDT12	nudix (nucleoside diphosphate linked moiety x)-type motif 12. [refseq;acc:nm_031438]	Ranked	242.159	265.104	1.09475
	SSB	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	Measured	4108.15	4808.93	1.17058
371	EPB41L1	band 4.1-like protein 1 (neuronal protein 4.1) (4.1n). [swissprot;acc:q9h4g0]	Squared	45985.9	56776	1.23464
	HTRA2	serine protease htra2, mitochondrial precursor (ec 3.4.21.-) (high temperature requirement protein a2) (htra2) (omi stress-regulated endoprotease) (serine proteinase omi). [swissprot;acc:o43464]	Measured	5067.02	5926.46	1.16961
	RPS6KC1	ribosomal protein s6 kinase, 52kda, polypeptide 1; ribosomal protein s6 kinase, 52kd, polypeptide 1. [refseq;acc:nm_012424]	Ranked	186.52	170.42	1.09447
	ZNF622	zinc finger-like protein 9. [refseq;acc:nm_033414]	Rooted	49.3451	54.4606	1.10367
372	no value	ribosomal protein s6 kinase-like 1. [refseq;acc:nm_031464]	Ranked	186.52	170.42	1.09447
	EPB41L3	band 4.1-like protein 3 (4.1b) (differentially expressed in adenocarcinoma of the lung protein 1) (dal-1). [swissprot;acc:q9y2j2]	Squared	45986.7	56776.8	1.23464
	HTRA4	probable serine protease htra4 precursor (ec 3.4.21.-). [swissprot;acc:p83105]	Measured	5067	5926.17	1.16956
	SLC45A2	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]	Rooted	49.3451	54.4606	1.10367
373	no value	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
	EPB41L2	band 4.1-like protein 2 (generally expressed protein 4.1) (4.1g). [swissprot;acc:o43491]	Squared	45986	56776.1	1.23464
	HTRA3	probable serine protease htra3 precursor (ec 3.4.21.-). [swissprot;acc:p83110]	Measured	5066.99	5926.1	1.16955
	MRPL11	60s ribosomal protein l11, mitochondrial precursor (l11mt) (cgi-113). [swissprot;acc:q9y3b7]	Ranked	242.37	265.255	1.09442
374	HTRA1	serine protease htra1 precursor (ec 3.4.21.-) (l56). [swissprot;acc:q92743]	Measured	5066.93	5925.38	1.16942
	RPL26	60s ribosomal protein l26. [swissprot;acc:q02877]	Rooted	50.2549	45.5599	1.10305
	SPTBN5	spectrin beta chain, brain 4 (spectrin, non-erythroid beta chain 4) (beta-v spectrin) (bspecv). [swissprot;acc:q9nrc6]	Squared	45987	56777.1	1.23463
	TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	Ranked	267.208	244.168	1.09436
375	LSM1	u6 snrna-associated sm-like protein lsm1 (small nuclear ribonuclear casm) (cancer-associated sm-like). [swissprot;acc:o15116]	Measured	4700.42	5492.63	1.16854
	POLR3A	dna-directed rna polymerase iii largest subunit (ec 2.7.7.6) (rpc155) (rpc1). [swissprot;acc:o14802]	Ranked	242.686	265.516	1.09407
	RPL35	60s ribosomal protein l35. [swissprot;acc:p42766]	Rooted	50.2545	45.5637	1.10295
	SDF4	45 kda calcium-binding protein precursor (cab45) (stromal cell-derived factor 4) (sdf-4). [swissprot;acc:q9brk5]	Squared	45987	56777.1	1.23463
376	no value	40s ribosomal protein s15 (rig protein). [swissprot;acc:p11174]	Rooted	50.2554	45.5688	1.10285
	C10orf83	44050 protein. [refseq;acc:nm_178832]	Measured	17385.9	14889.2	1.16769
	DDX56	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	Ranked	257.017	234.945	1.09395
	LGALS4	galectin-4 (lactose-binding lectin 4) (l-36 lactose binding protein) (l36lbp) (antigen ny-co-27). [swissprot;acc:p56470]	Squared	46021.4	56813.2	1.2345
377	MRPL2	mitochondrial ribosomal protein l2. [refseq;acc:nm_015950]	Rooted	50.2554	45.5687	1.10285
	ODC1	ornithine decarboxylase (ec 4.1.1.17) (odc). [swissprot;acc:p11926]	Squared	33044.9	40781.4	1.23412
	POLR1A	dna-directed rna polymerase i largest subunit (ec 2.7.7.6) (rna polymerase i 194 kda subunit) (rpa194). [swissprot;acc:o95602]	Ranked	242.691	265.481	1.09391

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.