MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1458 to 1507 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
729	no value	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	Subtracted	208.874	219.708	10.834
730	TIMM10	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	Divided			1.05187
			Subtracted			10.834
731	FH	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	Divided			1.05187
			Subtracted			10.834
732	no value	translin. [swissprot;acc:q15631]		224.385	235.131	10.746
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Divided	124.434	118.318	1.05169
733	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]		164	155.961	1.05154
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	Subtracted	224.385	235.131	10.746
734	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	Divided	232.601	244.534	1.0513
	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Subtracted	224.385	235.131	10.746
735	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]		229.045	218.343	10.702
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Divided	232.601	244.534	1.0513
736	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	N6AMT1	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	Subtracted	228.78	218.091	10.689
737	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]		221.968	211.326	10.642
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Divided	125.526	119.402	1.05129
738	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]	Subtracted	222.138	211.503	10.635
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Divided	222.825	211.966	1.05123
739	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Subtracted	272.878	283.472	10.594
	PFAS	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Divided	223.58	235.027	1.0512
740	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Subtracted	223.463	212.875	10.588
	ATIC	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	Divided	223.58	235.027	1.0512
741	PAICS	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]
	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]	Subtracted	223.463	212.875	10.588
742	no value	histone deacetylase 2 (hd2). [swissprot;acc:q92769]		226.003	215.541	10.462
	BRP44	brain protein 44. [swissprot;acc:o95563]	Divided	126.215	120.078	1.05111
743	MCFD2	multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	Subtracted	225.996	215.535	10.461
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Divided	126.215	120.078	1.05111
744	no value	dj153g14.2 (possible ca binding protein similar to nefa) (fragment). [sptrembl;acc:q9ujn8]	Subtracted	225.996	215.535	10.461
	SEPT6	septin 6. [swissprot;acc:q14141]	Divided	126.604	120.463	1.05098
745	HDAC1	histone deacetylase 1 (hd1). [swissprot;acc:q13547]	Subtracted	225.989	215.53	10.459
	SLC35B1	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	Divided	214.679	225.568	1.05072
746	EIF3I	eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]		250.465	238.38	1.0507
	TRIOBP	protein tara (trio-associated repeat on actin) (hrihfb2122). [swissprot;acc:q9h2d6]	Subtracted	213.804	224.226	10.422
747	no value	rho interacting protein 3. [refseq;acc:nm_015134]		213.803	224.224	10.421
		trinucleotide repeat containing 15. [refseq;acc:nm_015575]	Divided	250.465	238.38	1.0507
748	FBL	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]		245.246	233.483	1.05038
	PRPF3	u4/u6-associated rna splicing factor. [refseq;acc:nm_004698]	Subtracted	222.082	211.707	10.375
749	DNAJB4	dnaj homolog subfamily b member 4 (heat shock 40 kda protein 1 homolog) (heat shock protein 40 homolog) (hsp40 homolog). [swissprot;acc:q9udy4]		210.946	221.225	10.279
	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	Divided	221.968	211.326	1.05036
750	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]		222.138	211.503	1.05028
	PERLD1	cab2. [refseq;acc:nm_033419]	Subtracted	210.946	221.225	10.279
751	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Divided	223.463	212.875	1.04974
	DNAJB5	dnaj homolog subfamily b member 5 (heat shock protein hsp40-3) (heat shock protein cognate 40) (hsc40) (hsp40-2). [swissprot;acc:o75953]	Subtracted	210.946	221.225	10.279
752	DNAJB1	dnaj homolog subfamily b member 1 (heat shock 40 kda protein 1) (heat shock protein 40) (hsp40) (dnaj protein homolog 1) (hdj-1). [swissprot;acc:p25685]
	SLU7	step ii splicing factor slu7. [refseq;acc:nm_006425]	Divided	223.463	212.875	1.04974
753	ETF1	eukaryotic peptide chain release factor subunit 1 (erf1) (eukaryotic release factor 1) (tb3-1) (c11 protein). [swissprot;acc:p46055]	Subtracted	210.946	221.225	10.279
	LBP	lipopolysaccharide-binding protein precursor (lbp). [swissprot;acc:p18428]	Divided	224.434	235.583	1.04968
754	SPCS2	microsomal signal peptidase 25 kda subunit (ec 3.4.-.-) (spase 25 kda subunit) (spc25). [swissprot;acc:q15005]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.