MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	description	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1436 to 1485 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	red	green	network_comparison
718	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	CPXM1	Divided	223.121	211.685	1.05402
719	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]	DCTD	Subtracted	230.516	241.641	11.125
	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	NOL5A	Divided	247.769	235.074	1.054
720	60s acidic ribosomal protein p2. [swissprot;acc:p05387]	RPLP2		231.92	244.435	1.05396
	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	TREH	Subtracted	217.952	206.902	11.05
721	exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	EXOC5	Divided	214.765	203.8	1.0538
			Subtracted			10.965
722	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]	NET1		244.447	233.508	10.939
	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	TREH	Divided	217.952	206.902	1.05341
723	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]	no value		244.842	232.577	1.05274
	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	ARHGEF3	Subtracted	244.447	233.508	10.939
724	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	no value	Divided	244.842	232.577	1.05274
	down-regulated in metastasis. [refseq;acc:nm_014503]	UTP20	Subtracted	244.447	233.508	10.939
725	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	MVK	Divided	235.296	247.673	1.0526
	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	SLC35B1	Subtracted	214.679	225.568	10.889
726	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	FTSJ3	Divided	244.495	232.419	1.05196
	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	XAB2	Subtracted	222.825	211.966	10.859
727	probable serine/threonine-protein kinase kiaa0537 (ec 2.7.1.-). [swissprot;acc:o60285]	NUAK1	Divided	208.873	219.71	1.05188
			Subtracted			10.837
728	n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase (ec 2.4.1.149) (poly-n-acetyllactosamine extension enzyme) (i-beta- 1,3-n-acetylglucosaminyltransferase) (ignt) (udp-glcnac:betagal beta- 1,3-n-acetylglucosaminyltransferase 6). [swissprot;acc:o43505]	B3GNT1	Divided	208.874	219.708	1.05187
			Subtracted			10.834
729	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	no value	Divided			1.05187
			Subtracted			10.834
730	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	TIMM10	Divided			1.05187
			Subtracted			10.834
731	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	FH	Divided			1.05187
			Subtracted			10.834
732	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	SEPT8	Divided	124.434	118.318	1.05169
	translin. [swissprot;acc:q15631]	no value	Subtracted	224.385	235.131	10.746
733	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]	ACADVL	Divided	164	155.961	1.05154
	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	TSNAX	Subtracted	224.385	235.131	10.746
734	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	PQBP1
	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	no value	Divided	232.601	244.534	1.0513
735	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	RANP1
	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]	HEMK1	Subtracted	229.045	218.343	10.702
736	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]	no value	Divided	232.601	244.534	1.0513
	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	N6AMT1	Subtracted	228.78	218.091	10.689
737	exocyst complex component sec15b. [swissprot;acc:q9y2d4]	EXOC6B		221.968	211.326	10.642
	septin 10 isoform 1. [refseq;acc:nm_144710]	SEPT10	Divided	125.526	119.402	1.05129
738	exocyst complex component sec15a. [swissprot;acc:q8tag9]	EXOC6	Subtracted	222.138	211.503	10.635
	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	XAB2	Divided	222.825	211.966	1.05123
739	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	PDPK1	Subtracted	272.878	283.472	10.594
	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	PFAS	Divided	223.58	235.027	1.0512
740	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	ATIC
	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	no value	Subtracted	223.463	212.875	10.588
741	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]	PAICS	Divided	223.58	235.027	1.0512
	step ii splicing factor slu7. [refseq;acc:nm_006425]	SLU7	Subtracted	223.463	212.875	10.588
742	brain protein 44. [swissprot;acc:o95563]	BRP44	Divided	126.215	120.078	1.05111
	histone deacetylase 2 (hd2). [swissprot;acc:q92769]	no value	Subtracted	226.003	215.541	10.462
743	multiple coagulation factor deficiency 2; neural stem cell derived neuronal survival protein; multiple coagulation factor deficiency protein 2. [refseq;acc:nm_139279]	MCFD2		225.996	215.535	10.461

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.