MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

Navigation/Query Panel:
Click on the attribute name to hide/unhide it. The green arrows can be used to shift columns left/right. Exact word match is written as =..., regular expressions can be matched with ~.... To select all values larger or equal than use >.... This would be <... for values smaller or equal than. To select all values within a specific range use [...,...].

Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1432 to 1481 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
716	CPZ	cpz gene product. [refseq;acc:nm_003652]	Divided	223.121	211.685	1.05402
717	BPI	bactericidal permeability-increasing protein precursor (bpi) (cap 57). [swissprot;acc:p17213]	Subtracted	224.434	235.583	11.149
	CPE	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Divided	223.121	211.685	1.05402
718	CPXM1	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]
	PLTP	phospholipid transfer protein precursor (lipid transfer protein ii). [swissprot;acc:p55058]	Subtracted	224.434	235.583	11.149
719	DCTD	deoxycytidylate deaminase (ec 3.5.4.12) (dcmp deaminase). [swissprot;acc:p32321]		230.516	241.641	11.125
	NOL5A	nucleolar protein nop56 (nucleolar protein 5a). [swissprot;acc:o00567]	Divided	247.769	235.074	1.054
720	RPLP2	60s acidic ribosomal protein p2. [swissprot;acc:p05387]		231.92	244.435	1.05396
	TREH	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	Subtracted	217.952	206.902	11.05
721	EXOC5	exocyst complex component sec10 (hsec10). [swissprot;acc:o00471]	Divided	214.765	203.8	1.0538
			Subtracted			10.965
722	NET1	neuroepithelial cell transforming gene 1; guanine nucleotide regulatory protein (oncogene); rho guanine nucleotide exchange factor (gef) 8. [refseq;acc:nm_005863]		244.447	233.508	10.939
	TREH	trehalase precursor (ec 3.2.1.28) (alpha,alpha-trehalase) (alpha,alpha-trehalose glucohydrolase). [swissprot;acc:o43280]	Divided	217.952	206.902	1.05341
723	no value	histone h3.3 (h3.a) (h3.b) (h3.3q). [swissprot;acc:p06351]		244.842	232.577	1.05274
	ARHGEF3	rho guanine nucleotide exchange factor 3; rhogef protein; 59.8 kda protein; exchange factor found in platelets and leukemic and neuronal tissues, xpln. [refseq;acc:nm_019555]	Subtracted	244.447	233.508	10.939
724	no value	dj1099d15.1 (putative dnaj protein). [sptrembl;acc:q9h4j9]	Divided	244.842	232.577	1.05274
	UTP20	down-regulated in metastasis. [refseq;acc:nm_014503]	Subtracted	244.447	233.508	10.939
725	MVK	mevalonate kinase (ec 2.7.1.36) (mk). [swissprot;acc:q03426]	Divided	235.296	247.673	1.0526
	SLC35B1	solute carrier family 35, member b1; udp-galactose transporter related. [refseq;acc:nm_005827]	Subtracted	214.679	225.568	10.889
726	FTSJ3	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	Divided	244.495	232.419	1.05196
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Subtracted	222.825	211.966	10.859
727	NUAK1	probable serine/threonine-protein kinase kiaa0537 (ec 2.7.1.-). [swissprot;acc:o60285]	Divided	208.873	219.71	1.05188
			Subtracted			10.837
728	B3GNT1	n-acetyllactosaminide beta-1,3-n-acetylglucosaminyltransferase (ec 2.4.1.149) (poly-n-acetyllactosamine extension enzyme) (i-beta- 1,3-n-acetylglucosaminyltransferase) (ignt) (udp-glcnac:betagal beta- 1,3-n-acetylglucosaminyltransferase 6). [swissprot;acc:o43505]	Divided	208.874	219.708	1.05187
			Subtracted			10.834
729	no value	huntingtin interacting protein e; huntingtin interactor protein e. [refseq;acc:nm_007076]	Divided			1.05187
			Subtracted			10.834
730	TIMM10	mitochondrial import inner membrane translocase subunit tim10. [swissprot;acc:q9y5j8]	Divided			1.05187
			Subtracted			10.834
731	FH	fumarate hydratase, mitochondrial precursor (ec 4.2.1.2) (fumarase). [swissprot;acc:p07954]	Divided			1.05187
			Subtracted			10.834
732	no value	translin. [swissprot;acc:q15631]		224.385	235.131	10.746
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Divided	124.434	118.318	1.05169
733	ACADVL	acyl-coa dehydrogenase, very-long-chain specific, mitochondrial precursor (ec 1.3.99.-) (vlcad). [swissprot;acc:p49748]		164	155.961	1.05154
	TSNAX	translin-associated protein x (translin-associated factor x). [swissprot;acc:q99598]	Subtracted	224.385	235.131	10.746
734	no value	presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	Divided	232.601	244.534	1.0513
	PQBP1	polyglutamine binding protein 1; nuclear protein containing ww domain 38 kd. [refseq;acc:nm_005710]	Subtracted	224.385	235.131	10.746
735	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]		229.045	218.343	10.702
	RANP1	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	Divided	232.601	244.534	1.0513
736	no value	presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	N6AMT1	putative n6-dna-methyltransferase (ec 2.1.1.-) (protein pred28) (m.hsahemk2p). [swissprot;acc:q9y5n5]	Subtracted	228.78	218.091	10.689
737	EXOC6B	exocyst complex component sec15b. [swissprot;acc:q9y2d4]		221.968	211.326	10.642
	SEPT10	septin 10 isoform 1. [refseq;acc:nm_144710]	Divided	125.526	119.402	1.05129
738	EXOC6	exocyst complex component sec15a. [swissprot;acc:q8tag9]	Subtracted	222.138	211.503	10.635
	XAB2	xpa-binding protein 2 (hcnp protein) (pp3898). [swissprot;acc:q9hcs7]	Divided	222.825	211.966	1.05123
739	PDPK1	3-phosphoinositide dependent protein kinase-1 (ec 2.7.1.37) (hpdk1). [swissprot;acc:o15530]	Subtracted	272.878	283.472	10.594
	PFAS	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Divided	223.58	235.027	1.0512
740	no value	u2 small nuclear ribonucleoprotein auxiliary factor 35 kda subunit related-protein 1. [swissprot;acc:q15695]	Subtracted	223.463	212.875	10.588
	ATIC	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]	Divided	223.58	235.027	1.0512
741	PAICS	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.