MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 144 to 193 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Value Type	description	Network Comparison Type	red	green	network_comparison
18	PSCD2	Rooted	cytohesin 2 (arf nucleotide-binding site opener) (arno protein) (arf exchange factor). [swissprot;acc:q99418]	Subtracted	203.673	182.638	21.035
19	no value	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-5 like subunit. [swissprot;acc:q9y3k8]		266.865	336.178	69.313
	ATG4B	Measured	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]		24250	18164.9	6085.1
	MAGEF1	Squared	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		219048	129762	89286
	MFAP4	Measured	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]	Divided	677.5	1865.5	2.75351
		Squared			108.641	823.69	7.58176
	PRKRAP1	Rooted	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]		25.6987	43.561	1.69507
	PSCD4		cytohesin 4. [swissprot;acc:q9uia0]	Subtracted	203.673	182.638	21.035
	PYGB	Ranked	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Divided	185.678	245.247	1.32082
20	no value	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		40.3337	24.2744	1.66157
	GABARAP	Measured	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Subtracted	23421.5	17580.4	5841.1
	GNG11	Ranked	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-11 subunit. [swissprot;acc:p50152]		266.868	336.159	69.291
	MAGEB6B	Squared	melanoma antigen, family b, 6. [refseq;acc:nm_173523]		219048	129762	89286
	PPP1R14D	Measured	protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Divided	677.5	1865.5	2.75351
		Squared			108.641	823.69	7.58176
	PSCD3	Rooted	cytohesin 3 (arf nucleotide-binding site opener 3) (arno3 protein) (general receptor of phosphoinositides 1) (grp1). [swissprot;acc:o43739]	Subtracted	203.673	182.638	21.035
	PYGL	Ranked	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Divided	185.678	245.247	1.32082
21	no value	Squared	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Subtracted	219048	129762	89286
	ATG4A	Rooted	cysteine endopeptidase aut-like 2 isoform a; autophagy-related cysteine endopeptidase 2; autophagin 2. [refseq;acc:nm_052936]		153.602	133.195	20.407
	FCN2	Measured	ficolin 2 precursor (collagen/fibrinogen domain-containing protein 2) (ficolin-b) (ficolin b) (serum lectin p35) (ebp-37) (hucolin) (l- ficolin). [swissprot;acc:q15485]	Divided	677.5	1865.5	2.75351
		Squared			108.641	823.69	7.58176
	GNG12	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-12 subunit. [swissprot;acc:q9ubi6]		40.3337	24.2744	1.66157
	MAGED4	Measured	melanoma antigen, family d, 4 isoform 1; mage1 protein; mage-e1 protein; maged4 protein. [refseq;acc:nm_030801]	Subtracted	23693.7	18263	5430.7
	MYO15A	Ranked	myosin xv (unconventional myosin-15). [swissprot;acc:q9ukn7]	Divided	185.678	245.247	1.32082
	TMEM132A		gbp protein isoform a. [refseq;acc:nm_017870]	Subtracted	325.586	256.492	69.094
22	no value	Measured	protein phosphatase 1, regulatory (inhibitor) subunit 14c; serologically defined breast cancer antigen ny-br-81; pkc-potentiated pp1 inhibitory protein. [refseq;acc:nm_030949]	Divided	677.5	1865.5	2.75351
		Squared			108.641	823.69	7.58176
	GNG4	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-4 subunit. [swissprot;acc:p50150]		40.3357	24.2915	1.66049
	MAGEA9	Squared	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Subtracted	219048	129762	89286
	MAGEE2	Measured	hepatocellular carcinoma-associated protein hca3. [refseq;acc:nm_138703]		23693.7	18263	5430.7
	MAP1LC3B	Rooted	microtubule-associated proteins 1a/1b light chain 3b (map1a/map1b lc3 b) (map1a/1b light chain 3 b). [swissprot;acc:q9gzq8]		153.578	133.176	20.402
	PPP1R14A	Ranked	protein phosphatase 1, regulatory (inhibitor) subunit 14a; 17-kda pkc-potentiated inhibitory protein of pp1. [refseq;acc:nm_033256]		322	253	69
	PYGM		glycogen phosphorylase, muscle form (ec 2.4.1.1) (myophosphorylase). [swissprot;acc:p11217]	Divided	185.678	245.247	1.32082
23	no value	Measured	melanoma-associated antigen 3 (mage-3 antigen) (antigen mz2-d). [swissprot;acc:p43357]	Subtracted	23693.7	18263	5430.7
	GNG3	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-3 subunit. [swissprot;acc:p29798]	Divided	40.3358	24.2919	1.66046
	MAGEA8	Squared	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]	Subtracted	219048	129762	89286
	MAP1LC3A	Rooted	microtubule-associated proteins 1a/1b light chain 3a (map1a/map1b lc3 a) (map1a/1b light chain 3 a). [swissprot;acc:q9h492]		153.578	133.176	20.402
	MFAP4	Ranked	microfibril-associated glycoprotein 4 precursor. [swissprot;acc:p55083]		322	253	69
	MRPS17		28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]	Divided	58	44	1.31818
	NEUROD2	Squared	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]		143.692	457.521	3.18404
	TMEM132A	Measured	gbp protein isoform a. [refseq;acc:nm_017870]		699.76	1894.39	2.7072
24	ATG4B	Rooted	cysteine endopeptidase aut-like isoform b. [refseq;acc:nm_178326]	Subtracted	153.548	133.153	20.395
	CHD3	Squared	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	Divided	143.692	457.521	3.18404
	GNG8	Rooted	guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-8 subunit (gamma-9). [swissprot;acc:q9uk08]		40.336	24.2941	1.66032
	MAGEA11	Measured	melanoma-associated antigen 11 (mage-11 antigen). [swissprot;acc:p43364]	Subtracted	23693.7	18263	5430.7
	MAGEC1	Squared	melanoma-associated antigen c1 (mage-c1 antigen) (cancer-testis antigen ct7). [swissprot;acc:o60732]		219048	129762	89286
	PANK1	Ranked	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]	Divided	58	44	1.31818
	PPP1R14D		protein phosphatase 1, regulatory subunit 14d; pkc-dependent pp1 inhibitory protein. [refseq;acc:nm_017726]	Subtracted	322	253	69
	PRKRAP1	Measured	protein kinase, interferon-inducible double stranded rna dependent activator; protein activator of the interferon-induced protein kinase. [refseq;acc:nm_003690]	Divided	950.561	2108.52	2.21818
25	no value		guanine nucleotide-binding protein g(i)/g(s)/g(o) gamma-7 subunit. [swissprot;acc:o60262]		1833.01	892.67	2.0534

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.