MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 1380 to 1429 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
173	Ranked	UNC84A	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	Low confidence	1.05664	221.678	209.795
	Squared	ELAC2	elac homolog 2; putative prostate cancer susceptibility protein; elac (e. coli) homolog 2. [refseq;acc:nm_018127]		1.11437	67872.2	60906.5
		SEPT4	septin 4 (peanut-like protein 2) (brain protein h5) (cell division control-related protein 2) (hcdcrel-2) (bradeion beta) (ce5b3 beta) (cerebral protein-7) (hucep-7). [swissprot;acc:o43236]	High confidence	1.39258	82624.3	115061
	Rooted	MRPS17	28s ribosomal protein s17, mitochondrial precursor (mrp-s17) (hspc011). [swissprot;acc:q9y2r5]		1.1597	145.551	168.796
		SNRPA	u1 small nuclear ribonucleoprotein a (u1 snrnp a protein). [swissprot;acc:p09012]	Low confidence	1.06408	70.5964	75.1199
174	Measured	MXD1	mad protein (max dimerizer). [swissprot;acc:q05195]	High confidence	1.2958	4455.95	5774.03
		PSCD4	cytohesin 4. [swissprot;acc:q9uia0]	Low confidence	1.08115	12315	11390.6
	Ranked	DGCR14	dgcr14 protein (digeorge syndrome critical region 14) (es2 protein). [swissprot;acc:q96df8]	High confidence	1.17133	335	286
		FOXP1	forkhead box protein p1 (hspc215). [swissprot;acc:q9h334]	Low confidence	1.05624	219.6	207.907
	Squared	RBM5	rna-binding protein 5 (rna binding motif protein 5) (putative tumor suppressor luca15) (g15 protein). [swissprot;acc:p52756]		1.11409	67801.5	60858
		ZNF547	sedlin. [swissprot;acc:o14582]	High confidence	1.39189	112820	157033
	Rooted	PANK1	pantothenate kinase 1 (ec 2.7.1.33) (pantothenic acid kinase 1) (hpank1) (hpank). [swissprot;acc:q8te04]		1.1597	145.551	168.796
		TNS3	tumor endothelial marker 6; thyroid specific ptb domain protein; tensin 3. [refseq;acc:nm_022748]	Low confidence	1.06398	65.8885	70.104
175	Measured	MAN1B1	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ec 3.2.1.113) (er alpha-1,2-mannosidase) (mannosidase alpha class 1b member 1) (man9glcnac2-specific processing alpha-mannosidase). [swissprot;acc:q9ukm7]		1.08076	7004.28	7569.94
		MXI1	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]	High confidence	1.29553	4456.67	5773.77
	Ranked	COPS3	cop9 constitutive photomorphogenic homolog subunit 3; cop9 complex subunit 3; jab1-containing signalosome subunit 3. [refseq;acc:nm_003653]		1.17123	199.949	234.187
		FOXP4	forkhead box p4; fork head-related protein like a; winged-helix repressor foxp4. [refseq;acc:nm_138457]	Low confidence	1.05623	219.593	207.903
	Squared	no value	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	High confidence	1.39189	112820	157033
		CTPS2	cytidine triphosphate synthase ii; ctp synthetase type 2; utp-ammonia ligase; ctp synthetase isoform; cytidine 5'-triphosphate synthetase 2. [refseq;acc:nm_019857]	Low confidence	1.11223	65119.3	58548.3
	Rooted	FOXP3	forkhead box protein p3 (zinc finger protein jm2) (scurfin). [swissprot;acc:q9bzs1]		1.06343	63.3478	67.3658
		PANK2	pantothenate kinase 2, mitochondrial precursor (ec 2.7.1.33) (pantothenic acid kinase 2) (hpank2). [swissprot;acc:q9bz23]	High confidence	1.1597	145.551	168.796
176	Measured	MXD4	max-interacting transcriptional repressor mad4 (max-associated protein 4) (max dimerization protein 4). [swissprot;acc:q14582]		1.29544	4456.93	5773.67
		PSEN2	presenilin 2 (ps-2) (stm-2) (e5-1) (ad3lp) (ad5). [swissprot;acc:p49810]	Low confidence	1.08076	7004.28	7569.94
	Ranked	POLE4	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	High confidence	1.1689	275.754	235.908
		TNS3	tumor endothelial marker 6; thyroid specific ptb domain protein; tensin 3. [refseq;acc:nm_022748]	Low confidence	1.05601	219.336	207.703
	Squared	CTPS	ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]		1.11214	65033.7	58476.1
		TRAPPC3	bet3 homolog. [swissprot;acc:o43617]	High confidence	1.39189	112820	157033
	Rooted	FER	proto-oncogene tyrosine-protein kinase fer (ec 2.7.1.112) (p94-fer) (c-fer). [swissprot;acc:p16591]	Low confidence	1.06339	66.7098	70.9384
		PANK3	pantothenate kinase 3 (ec 2.7.1.33) (pantothenic acid kinase 3) (hpank3). [swissprot;acc:q9h999]	High confidence	1.1597	145.551	168.796
177	Measured	RAB24	max dimerization protein 3; likely ortholog of mouse max dimerization protein 3. [refseq;acc:nm_031300]		1.29539	4457.06	5773.63
		RHBDL3	rhomboid-related protein 4 (ec 3.4.21.-) (ventrhoid transmembrane protein). [swissprot;acc:p58872]	Low confidence	1.08076	23239.9	21503.3
	Ranked	NCBP2L	dj820b18.1 (similar to nuclear cap binding protein) (fragment). [sptrembl;acc:q8wwk2]	High confidence	1.1663	229.406	196.695
		POP7	ribonuclease p protein subunit p20 (ec 3.1.26.5) (rnasep protein p20) (hpop7). [swissprot;acc:o75817]	Low confidence	1.0555	209.954	221.607
	Squared	PAPOLA	poly(a) polymerase alpha (ec 2.7.7.19) (pap) (polynucleotide adenylyltransferase alpha) (fragment). [swissprot;acc:p51003]		1.11181	51835.4	46622.5
		SEPT1	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	High confidence	1.38401	78383	108483
	Rooted	RPL29	60s ribosomal protein l29 (cell surface heparin binding protein hip). [swissprot;acc:p47914]	Low confidence	1.06338	66.7116	70.9396
		SLC25A43	mitochondrial solute carrier protein. [refseq;acc:nm_145305]	High confidence	1.1597	145.551	168.796
178	Measured	MYO5B	myosin vb (myosin 5b) (fragment). [swissprot;acc:q9ulv0]		1.29238	21591.5	27904.5
		TEGT	bax inhibitor-1 (bi-1) (testis enhanced gene transcript). [swissprot;acc:p55061]	Low confidence	1.08076	23239.9	21503.3
	Ranked	no value	formin binding protein 3; fas-ligand associated factor 1; huntingtin-interacting protein a; ny-ren-6 antigen. [refseq;acc:nm_017892]	High confidence	1.1652	226.887	194.72
		BPNT1	3'(2'), 5'-bisphosphate nucleotidase 1; bisphosphate 3'-nucleotidase; bpntase; pap-inositol-1,4-phosphatase. [refseq;acc:nm_006085]	Low confidence	1.0555	209.954	221.607
	Squared	CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	High confidence	1.37988	25326.4	18354.1
		PRKAG2	5'-amp-activated protein kinase, gamma-2 subunit (ampk gamma-2 chain) (ampk gamma2) (h91620p). [swissprot;acc:q9ugj0]	Low confidence	1.11179	54860.1	49344.1
	Rooted	FES	proto-oncogene tyrosine-protein kinase fes/fps (ec 2.7.1.112) (c-fes). [swissprot;acc:p07332]		1.06336	66.7139	70.9412
		TFDP2	transcription factor dp-2 (e2f dimerization partner 2). [swissprot;acc:q14188]	High confidence	1.1572	45.7414	52.932
179	Measured	FBXW7	f-box protein fbw7 isoform 2; archipelago, drosophila, homolog of; f-box protein fbw7; f-box protein sel-10; homolog of c elegans sel-10. [refseq;acc:nm_018315]	Low confidence	1.08076	7004.28	7569.94
		MYO5C	myosin vc (myosin 5c). [swissprot;acc:q9nqx4]	High confidence	1.29238	21591.5	27904.5
	Ranked	no value	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]		1.16476	226.884	194.79
		RPL6	60s ribosomal protein l6 (tax-responsive enhancer element binding protein 107) (taxreb107) (neoplasm-related protein c140). [swissprot;acc:q02878]	Low confidence	1.0555	209.954	221.607
	Squared	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	High confidence	1.37987	25326.3	18354.1

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.