MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Value Type	Gene	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1380 to 1429 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
345	Rooted	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	56.2615	62.2958	1.10725
346	Measured	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	14229.2	16780.7	1.17931
	Ranked	40s ribosomal protein s3. [swissprot;acc:p23396]	241.612	265.119	1.09729
	Squared	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	34018.3	42373	1.24559
	Rooted	grb2-related adaptor protein. [swissprot;acc:q13588]	61.4282	68.0107	1.10716
347	Measured	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	4991.02	5885.09	1.17914
	Ranked	gtp:amp phosphotransferase mitochondrial (ec 2.7.4.10) (ak3) (adenylate kinase 3 alpha like 1). [swissprot;acc:q9uij7]	242.14	265.697	1.09729
	Squared	small nuclear ribonucleoprotein sm d2 (snrnp core protein d2) (sm-d2). [swissprot;acc:p43330]	16573.6	20637.8	1.24522
	Rooted	cg9578-like; yeast ypr037w and worm c02c2.6 predicted proteins-like. [refseq;acc:nm_152902]	66.4284	60.0004	1.10713
348	Measured	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	4991.02	5885.09	1.17914
	Ranked	adenylate kinase isoenzyme 4, mitochondrial (ec 2.7.4.3) (atp-amp transphosphorylase). [swissprot;acc:p27144]	242.14	265.696	1.09728
	Squared	golgi reassembly stacking protein 2; golgi reassembly stacking protein 2, 55 kda. [refseq;acc:nm_015530]	42566.2	52985.3	1.24477
	Rooted	ad24 protein. [refseq;acc:nm_022451]	49.2558	54.5235	1.10695
349	Measured	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	4714.85	5554.38	1.17806
	Ranked	surfeit locus protein 5. [swissprot;acc:q15528]	242.14	265.696	1.09728
	Squared	sh3-containing grb2-like protein 2 (sh3 domain protein 2a) (endophilin 1) (een-b1). [swissprot;acc:q99962]	35533.9	44227	1.24464
	Rooted	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	56.0061	61.9704	1.10649
350	Measured	sedlin. [swissprot;acc:o14582]	17396.9	20483.9	1.17745
	Ranked	zinc finger protein 291. [swissprot;acc:q9by12]	242.14	265.696	1.09728
	Squared	armet protein precursor (arginine-rich protein). [swissprot;acc:p55145]	35508.7	44191.4	1.24452
	Rooted	neuron navigator 2 isoform l; retinoic acid inducible in neuroblastoma; pore membrane and/or filament interacting like protein 2; helicase helad1. [refseq;acc:nm_145117]	61.3383	67.8668	1.10643
351	Measured	synbindin (trs23 homolog) (hematopoietic stem/progenitor cell protein 172) (hspc172) (ptd009) (cgi-104). [swissprot;acc:q9y296]	17396.9	20483.9	1.17745
	Ranked	peroxisome biogenesis factor 1 (peroxin-1) (peroxisome biogenesis disorder protein 1). [swissprot;acc:o43933]	242.14	265.696	1.09728
	Squared	histidine decarboxylase (ec 4.1.1.22) (hdc). [swissprot;acc:p19113]	35508.6	44191.3	1.24452
	Rooted	e2a-pbx1-associated protein; putative 47 kda protein. [refseq;acc:nm_020140]	61.3352	67.8618	1.10641
352	Measured	bet3 homolog. [swissprot;acc:o43617]	17396.9	20483.9	1.17745
	Ranked	protein 1-4 (atp binding protein associated with cell differentiation). [swissprot;acc:o14530]	242.14	265.696	1.09728
	Squared	40s ribosomal protein s28. [swissprot;acc:p25112]	30682.9	38183.6	1.24446
	Rooted	neuron navigator 1; neuron navigator-1; pore membrane and/or filament interacting like protein 3. [refseq;acc:nm_020443]	61.3354	67.8621	1.10641
353	Measured	p66 alpha. [refseq;acc:nm_017660]	12839	10911.1	1.17669
	Ranked	rgs19-interacting protein 1 (gaip c-terminus interacting protein gipc) (rgs-gaip interacting protein) (tax interaction protein 2) (tip-2). [swissprot;acc:o14908]	231.73	211.252	1.09694
	Squared	54 kda nuclear rna- and dna-binding protein (p54(nrb)) (p54nrb) (55 kda nuclear protein) (nmt55) (non-pou domain-containing octamer- binding protein) (dna-binding p52/p100 complex, 52 kda subunit). [swissprot;acc:q15233]	71383	57399.3	1.24362
	Rooted	neuron navigator 3; pore membrane and/or filament interacting like protein 1; steerin 3. [refseq;acc:nm_014903]	61.3354	67.8623	1.10641
354	Measured	transcription repressor p66 beta component of the mecp1 complex. [refseq;acc:nm_020699]	12839	10911.1	1.17669
	Ranked	syntaxin 10 (syn10). [swissprot;acc:o60499]	234.691	257.442	1.09694
	Squared	paraspeckle protein 1. [refseq;acc:nm_018282]	71360.3	57385.8	1.24352
	Rooted	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	49.2848	54.5246	1.10632
355	Measured	tyrosine aminotransferase (ec 2.6.1.5) (l-tyrosine:2-oxoglutarate aminotransferase) (tat). [swissprot;acc:p17735]	12839	10911.1	1.17669
	Ranked	syntaxin 6. [swissprot;acc:o43752]	234.673	257.414	1.09691
	Squared	sad1/unc-84 protein-like 1. [swissprot;acc:o94901]	15588.1	19381.8	1.24337
	Rooted	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	58.0752	64.23	1.10598
356	Measured	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	11004.2	12944.2	1.1763
	Ranked	60s ribosomal protein l10a (csa-19). [swissprot;acc:p53025]	243.24	266.796	1.09684
	Squared	sh3-containing grb2-like protein 3 (sh3 domain protein 2c) (een-b2). [swissprot;acc:q99963]	35247.5	43820.5	1.24322
	Rooted	splicing factor 3b subunit 2 (spliceosome associated protein 145) (sap 145) (sf3b150) (pre-mrna splicing factor sf3b 145 kda subunit). [swissprot;acc:q13435]	58.0752	64.23	1.10598
357	Measured	imp2 inner mitochondrial membrane protease-like; inner mitochondrial membrane peptidase 2 like. [refseq;acc:nm_032549]	5061.11	5950.22	1.17567
	Ranked	60s ribosomal protein l10 (qm protein) (tumor suppressor qm) (laminin receptor homolog). [swissprot;acc:p27635]	243.12	266.661	1.09683
	Squared	uncharacterized hematopoietic stem/progenitor cells protein mds026. [sptrembl;acc:q9nz48]	9811.86	7908.29	1.24071
	Rooted	growth factor receptor-bound protein 2 (grb2 adapter protein) (sh2/sh3 adapter grb2) (ash protein). [swissprot;acc:p29354]	61.2684	67.755	1.10587
358	Measured	microsomal signal peptidase 18 kda subunit (ec 3.4.-.-) (spase 18 kda subunit) (spc18) (endopeptidase sp18). [swissprot;acc:p21378]	5061.11	5950.22	1.17567

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.