MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Interaction Map	Network Comparison Type	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1351 to 1400 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	description	Network Comparison Type	red	green	network_comparison
676	MRTO4	ribosomal protein p0-like protein; 60s acidic ribosomal protein po; ribosomal protein, large, p0-like. [refseq;acc:nm_016183]	Subtracted	245.84	257.636	11.796
	POLR2G	dna-directed rna polymerase ii 19 kda polypeptide (ec 2.7.7.6) (rpb7). [swissprot;acc:p52433]	Divided	232.469	245.613	1.05654
677	FBL	fibrillarin (34 kda nucleolar scleroderma antigen). [swissprot;acc:p22087]	Subtracted	245.246	233.483	11.763
	LSM4	u6 snrna-associated sm-like protein lsm4 (glycine-rich protein) (grp). [swissprot;acc:q9y4z0]	Divided	228.944	216.745	1.05628
678	PPIL4	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Subtracted	226.135	214.405	11.73
	SNX5	sorting nexin 5. [swissprot;acc:q9y5x3]	Divided	208.482	220.175	1.05609
679	no value	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		132.413	125.389	1.05602
	SNX5	sorting nexin 5. [swissprot;acc:q9y5x3]	Subtracted	208.482	220.175	11.693
680	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Divided	132.413	125.389	1.05602
	SFRS18	sr rich protein. [refseq;acc:nm_032870]	Subtracted	225.293	213.64	11.653
681	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Divided	132.413	125.389	1.05602
	SNW1	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	Subtracted	220.593	208.987	11.606
682	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Divided	132.413	125.389	1.05602
	NAT10	upf0202 protein kiaa1709. [swissprot;acc:q9h0a0]	Subtracted	246.055	234.458	11.597
683	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Divided	132.413	125.389	1.05602
	OSTF1	osteoclast stimulating factor 1. [swissprot;acc:q92882]	Subtracted	231.809	243.289	11.48
684	HOXB5	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Divided	132.413	125.389	1.05602
	PFAS	phosphoribosylformylglycinamidine synthase (ec 6.3.5.3) (fgam synthase) (fgams) (formylglycinamide ribotide amidotransferase) (fgarat) (formylglycinamide ribotide synthetase). [swissprot;acc:o15067]	Subtracted	223.58	235.027	11.447
685	ATIC	bifunctional purine biosynthesis protein purh [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (ec 2.1.2.3) (aicar transformylase); imp cyclohydrolase (ec 3.5.4.10) (inosinicase) (imp synthetase) (atic)]. [swissprot;acc:p31939]
	HOXA5	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Divided	132.413	125.389	1.05602
686	no value	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]
	PAICS	multifunctional protein ade2 [includes: phosphoribosylaminoimidazole- succinocarboxamide synthase (ec 6.3.2.6) (saicar synthetase); phosphoribosylaminoimidazole carboxylase (ec 4.1.1.21) (air carboxylase) (airc)]. [swissprot;acc:p22234]	Subtracted	223.58	235.027	11.447
687	EIF3M	dendritic cell protein. [refseq;acc:nm_006360]		223.121	211.685	11.436
	HSD17B14	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	Divided	132.413	125.389	1.05602
688	CPXM2	potential carboxypeptidase-like protein x2 precursor. [swissprot;acc:q8n436]	Subtracted	223.121	211.685	11.436
	POLR2D	dna-directed rna polymerase ii 16 kda polypeptide (ec 2.7.7.6) (rpb4). [swissprot;acc:o15514]	Divided	237.554	250.823	1.05586
689	CPN1	carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]	Subtracted	223.121	211.685	11.436
	TCP1	t-complex protein 1, alpha subunit (tcp-1-alpha) (cct-alpha). [swissprot;acc:p17987]	Divided	135.379	128.225	1.05579
690	CPZ	cpz gene product. [refseq;acc:nm_003652]	Subtracted	223.121	211.685	11.436
	SNW1	nuclear protein skip (ski-interacting protein) (snw1 protein) (nuclear receptor coactivator ncoa-62). [swissprot;acc:q13573]	Divided	220.593	208.987	1.05553
691	BCAS2	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		217.602	206.195	1.05532
	CPE	carboxypeptidase h precursor (ec 3.4.17.10) (cph) (carboxypeptidase e) (cpe) (enkephalin convertase) (prohormone processing carboxypeptidase). [swissprot;acc:p16870]	Subtracted	223.121	211.685	11.436
692	CDC5L	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Divided	217.602	206.195	1.05532
	CPXM1	potential carboxypeptidase x precursor (ec 3.4.17.-) (metallocarboxypeptidase cpx-1). [swissprot;acc:q96sm3]	Subtracted	223.121	211.685	11.436
693	BCAS2	breast carcinoma amplified sequence 2; spliceosome associated protein, amplified in breast cancer. [refseq;acc:nm_005872]		217.602	206.195	11.407
	NOVA1	rna-binding protein nova-1 (neuro-oncological ventral antigen 1) (onconeural ventral antigen-1) (paraneoplastic ri antigen) (ventral neuron-specific protein 1). [swissprot;acc:p51513]	Divided	222.554	234.847	1.05524
694	CDC5L	cdc5-like; cdc5 (cell division cycle 5, s. pombe, homolog)-like; cell division cycle 5, s. pombe, homolog-like; cdc5-related protein. [refseq;acc:nm_001253]	Subtracted	217.602	206.195	11.407
	POLE	dna polymerase epsilon, catalytic subunit a (ec 2.7.7.7) (dna polymerase ii subunit a). [swissprot;acc:q07864]	Divided	241.907	229.35	1.05475
695	NUBP1	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	Subtracted	210.739	199.398	11.341
	PPIL4	peptidylprolyl isomerase-like 4; cyclophilin-type peptidyl-prolyl cis-trans isomerase; ppiase; serologically defined breast cancer antigen ny-br-18. [refseq;acc:nm_139126]	Divided	226.135	214.405	1.05471
696	NUBP2	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	Subtracted	210.739	199.398	11.341
	SFRS18	sr rich protein. [refseq;acc:nm_032870]	Divided	225.293	213.64	1.05455
697	FTH1	ferritin heavy chain (ferritin h subunit). [swissprot;acc:p02794]		220.444	209.113	1.05419
			Subtracted			11.331
698	CREG2	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]		220.438	209.118	11.32
	FTMT	mitochondrial ferritin; ferritin heavy chain-like; ferritin h subunit. [refseq;acc:nm_177478]	Divided	220.437		1.05413
699	no value	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]	Subtracted	220.438		11.32
	CREG2	cellular repressor of e1a-stimulated genes 2. [refseq;acc:nm_153836]	Divided			1.05413
700	no value	dj681n20.2 (novel protein similar to ferritin, light polypeptide (ftl)). [sptrembl;acc:q9byw6]
	DLGAP1	disks large-associated protein 1 (dap-1) (guanylate kinase-associated protein) (hgkap) (sap90/psd-95-associated protein 1) (sapap1) (psd- 95/sap90 binding protein 1). [swissprot;acc:o14490]	Subtracted			11.32

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.