MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	description	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1336 to 1385 of 12912 in total

Network Comparison Type  : Divided
Interaction Map  : High confidence
Filtered  : 1

Rank	Value Type	description	red	green	network_comparison
334	Rooted	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	58.6096	64.9655	1.10844
335	Measured	probable atp-dependent 61 kda nucleolar rna helicase (dead-box protein 21). [swissprot;acc:q9ny93]	3494.31	4129.6	1.18181
	Ranked	chromodomain helicase dna binding protein 5. [refseq;acc:nm_015557]	312	284	1.09859
	Squared	ribosomal protein l24-like; 60s ribosomal protein l30 isolog; my024 protein; homolog of yeast ribosomal like protein 24. [refseq;acc:nm_016304]	30651.3	38253.3	1.24802
	Rooted	40s ribosomal protein s11. [swissprot;acc:p04643]	50.4705	45.5342	1.10841
336	Measured	dna polymerase epsilon p12 subunit (dna polymerase epsilon subunit 4). [swissprot;acc:q9nr33]	3751.3	4431.34	1.18128
	Ranked	cyclin-dependent kinase 2-associated protein 1 (cdk2-associated protein 1) (putative oral cancer suppressor) (deleted in oral cancer- 1) (doc-1). [swissprot;acc:o14519]	312	284	1.09859
	Squared	j kappa-recombination signal binding protein (rbp-j kappa). [swissprot;acc:q06330]	46785.7	58383.2	1.24789
	Rooted	60s ribosomal protein l11. [swissprot;acc:p39026]	50.3167	45.4063	1.10814
337	Measured	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	20446.1	24136.4	1.18049
	Ranked	60s ribosomal protein l12. [swissprot;acc:p30050]	243.583	267.527	1.0983
	Squared	human immunodeficiency virus type i enhancer binding protein 3. [refseq;acc:nm_024503]	46785.7	58383.2	1.24789
	Rooted	carboxypeptidase b precursor. [refseq;acc:nm_020361]	77.5801	70.0182	1.108
338	Measured	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	20446.1	24136.4	1.18049
	Ranked	60s ribosomal protein l12 like protein. [sptrembl;acc:o60886]	243.583	267.528	1.0983
	Squared	zinc finger protein 40 (human immunodeficiency virus type i enhancer- binding protein 1) (hiv-ep1) (major histocompatibility complex binding protein 1) (mbp-1) (positive regulatory domain ii binding factor 1) (prdii-bf1). [swissprot;acc:p15822]	46785.7	58383.2	1.24789
	Rooted	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	77.58	70.0181	1.108
339	Measured	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	20446.1	24136.4	1.18049
	Ranked	dj999l4.1 (novel protein similar to ribosomal protein l12 (rpl12)). [sptrembl;acc:q9nq02]	243.583	267.527	1.0983
	Squared	human immunodeficiency virus type i enhancer-binding protein 2 (hiv-ep2). [swissprot;acc:p31629]	46785.7	58383.2	1.24789
	Rooted	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	77.5797	70.0179	1.108
340	Measured	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	20446.1	24136.4	1.18049
	Ranked	myelin gene expression factor 2. [refseq;acc:nm_016132]	235.383	258.476	1.09811
	Squared	ribonucleotide reductase m2 b (tp53 inducible); p53-inducible ribonucleotide reductase small subunit 2 homolog. [refseq;acc:nm_015713]	32117	40054	1.24713
	Rooted	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	58.4926	64.8047	1.10791
341	Measured	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	20446.1	24136.4	1.18049
	Ranked	60s ribosomal protein l9. [swissprot;acc:p32969]	240.243	263.798	1.09805
	Squared	ribonucleoside-diphosphate reductase m1 chain (ec 1.17.4.1) (ribonucleotide reductase large chain). [swissprot;acc:p23921]	32056.4	39965.8	1.24673
	Rooted	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	51.9812	57.5858	1.10782
342	Measured	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	20446.1	24136.4	1.18049
	Ranked	40s ribosomal protein s20. [swissprot;acc:p17075]	243.5	267.21	1.09737
	Squared	hepatocyte growth factor-regulated tyrosine kinase substrate; human growth factor-regulated tyrosine kinase substrate. [refseq;acc:nm_004712]	70830.5	56822	1.24653
	Rooted	probable rrna processing protein ebp2 (ebna1 binding protein 2) (nucleolar protein p40). [swissprot;acc:q99848]	49.2715	54.5757	1.10765
343	Measured	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	20446.1	24136.4	1.18049
	Ranked	protein arginine n-methyltransferase 3 (ec 2.1.1.-) (fragment). [swissprot;acc:o60678]	241.625	265.136	1.0973
	Squared	conserved oligomeric golgi complex component 7. [swissprot;acc:p83436]	70830.5	56822	1.24653
	Rooted	60s ribosomal protein l17 (l23). [swissprot;acc:p18621]	50.3169	45.4333	1.10749
344	Measured	homeobox protein hox-a4 (hox-1d) (hox-1.4). [swissprot;acc:q00056]	20446.1	24136.4	1.18049
	Ranked	40s ribosomal protein s2 (s4) (llrep3 protein). [swissprot;acc:p15880]	241.625	265.136	1.0973
	Squared	isocitrate dehydrogenase [nadp], mitochondrial precursor (ec 1.1.1.42) (oxalosuccinate decarboxylase) (idh) (nadp+-specific icdh) (idp) (icd-m). [swissprot;acc:p48735]	37226.9	46400.1	1.24641
	Rooted	suppressor of swi4 1 homolog (ssf-1) (peter pan homolog). [swissprot;acc:q9nq55]	49.4233	54.7327	1.10743
345	Measured	retinal short-chain dehydrogenase/reductase 3. [refseq;acc:nm_016246]	20446.1	24136.4	1.18049
	Ranked	ump-cmp kinase (ec 2.7.4.14) (cytidylate kinase) (deoxycytidylate kinase) (cytidine monophosphate kinase). [swissprot;acc:p30085]	242.14	265.697	1.09729
	Squared	sh3-containing grb2-like protein 1 (sh3 domain protein 2b) (extra eleven-nineteen leukemia fusion gene) (een) (een fusion partner of mll). [swissprot;acc:q99961]	35793	44595.3	1.24592
	Rooted	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	56.2615	62.2958	1.10725
346	Measured	septin 1 (larp) (serologically defined breast cancer antigen ny-br- 24). [swissprot;acc:q8wyj6]	14229.2	16780.7	1.17931
	Ranked	40s ribosomal protein s3. [swissprot;acc:p23396]	241.612	265.119	1.09729
	Squared	importin-alpha re-exporter (chromosome segregation 1-like protein) (cellular apoptosis susceptibility protein). [swissprot;acc:p55060]	34018.3	42373	1.24559
	Rooted	grb2-related adaptor protein. [swissprot;acc:q13588]	61.4282	68.0107	1.10716
347	Measured	enteropeptidase precursor (ec 3.4.21.9) (enterokinase). [swissprot;acc:p98073]	4991.02	5885.09	1.17914

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.