MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 2480 to 2529 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	red	green	network_comparison
1240	signal transducer and activator of transcription 1-alpha/beta (transcription factor isgf-3 components p91/p84). [swissprot;acc:p42224]	Subtracted	222.574	227.752	5.178
1241	keratin associated protein 4.9 (fragment). [sptrembl;acc:q9byq8]	Divided	219.354	224.7	1.02437
	signal transducer and activator of transcription 3 (acute-phase response factor). [swissprot;acc:p40763]	Subtracted	222.573	227.75	5.177
1242	keratin associated protein 4-12; keratin associated protein 4.12. [refseq;acc:nm_031854]	Divided	219.354	224.7	1.02437
	ral guanine nucleotide dissociation stimulator (ralgef) (ralgds). [swissprot;acc:q12967]	Subtracted	162.055	156.884	5.171
1243	keratin associated protein 1.5. [refseq;acc:nm_031957]	Divided	219.354	224.699	1.02437
	signal transducer and activator of transcription 6 (il-4 stat). [swissprot;acc:p42226]	Subtracted	222.569	227.739	5.17
1244	star-related lipid transfer protein 6 (stard6) (start domain- containing protein 6). [swissprot;acc:p59095]	Divided	219.354	224.7	1.02437
	tumor protein d53 (hd53) (d52-like 1). [swissprot;acc:q16890]	Subtracted	206.774	211.936	5.162
1245	keratin, ultra high-sulfur matrix protein b (uhs keratin b) (uhs kerb). [swissprot;acc:o75690]	Divided	219.354	224.699	1.02437
	tumor protein d52 (n8 protein). [swissprot;acc:p55327]	Subtracted	206.771	211.926	5.155
1246	keratin, ultra high-sulfur matrix protein a (uhs keratin a) (uhs kera). [swissprot;acc:p26371]	Divided	219.354	224.699	1.02437
	sestrin 3. [swissprot;acc:p58005]	Subtracted	218.368	213.219	5.149
1247	sestrin 2 (hi95). [swissprot;acc:p58004]
	star-related lipid transfer protein 5 (stard5) (start domain- containing protein 5). [swissprot;acc:q9nsy2]	Divided	219.354	224.7	1.02437
1248	cytochrome p450 4a11 precursor (ec 1.14.15.3) (cypiva11) (fatty acid omega-hydroxylase) (p-450 hk omega) (lauric acid omega-hydroxylase) (cyp4aii) (p450-hl-omega). [swissprot;acc:q02928]	Subtracted	218.368	213.22	5.148
	keratin associated protein 4.4. [refseq;acc:nm_032524]	Divided	219.354	224.699	1.02437
1249	alpha-parvin (calponin-like integrin-linked kinase binding protein) (ch-ilkbp). [swissprot;acc:q9nvd7]			224.7
	cytochrome p450 4f3 (ec 1.14.13.30) (cypivf3) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:q08477]	Subtracted	218.368	213.22	5.148
1250	cytochrome p450 4f8 (ec 1.14.14.1) (cypivf8). [swissprot;acc:p98187]
	pinch protein (particularly interesting new cys-his protein) (lim and senescent cell antigen-like domains 1). [swissprot;acc:p48059]	Divided	219.354	224.7	1.02437
1251	integrin-linked protein kinase 1 (ec 2.7.1.-) (ilk-1) (59 kda serine/threonine protein kinase) (p59ilk). [swissprot;acc:q13418]
	likely ortholog of rat cytochrome p450 4x1. [refseq;acc:nm_178033]	Subtracted	218.368	213.22	5.148
1252	cytochrome p450 4f12 (ec 1.14.14.1) (cypivf12). [swissprot;acc:q9hcs2]
	star-related lipid transfer protein 4 (stard4) (start domain- containing protein 4). [swissprot;acc:q96dr4]	Divided	219.354	224.7	1.02437
1253	cytochrome p450 4f2 (ec 1.14.13.30) (cypivf2) (leukotriene-b4 omega- hydroxylase) (leukotriene-b4 20-monooxygenase) (cytochrome p450- ltb-omega). [swissprot;acc:p78329]	Subtracted	218.368	213.22	5.148
	ras suppressor protein 1 (rsu-1) (rsp-1). [swissprot;acc:q15404]	Divided	219.354	224.7	1.02437
1254	cytochrome p450 4f11 (ec 1.14.14.1) (cypivf11). [swissprot;acc:q9hbi6]	Subtracted	218.368	213.22	5.148
	ras-gtpase-activating protein binding protein 1 (gap sh3-domain binding protein 1) (g3bp-1). [swissprot;acc:q13283]	Divided	219.354	224.7	1.02437
1255	dj18d14.4 (cytochrome p450, subfamily iva, polypeptide 11). [sptrembl;acc:q9ntl5]	Subtracted	218.368	213.22	5.148
	ras-gtpase-activating protein binding protein 2 (gap sh3-domain binding protein 2) (g3bp-2). [swissprot;acc:q9un86]	Divided	219.354	224.7	1.02437
1256	cytochrome p450 4b1 (ec 1.14.14.1) (cypivb1) (p450-hp). [swissprot;acc:p13584]	Subtracted	218.368	213.22	5.148
	keratin associated protein 1-3; keratin associated protein 1.3. [refseq;acc:nm_030966]	Divided	219.354	224.699	1.02437
1257	espin. [refseq;acc:nm_031475]			224.7
	flotillin-1. [swissprot;acc:o75955]	Subtracted	218.368	213.22	5.148
1258	cytochrome p450 2d6 (ec 1.14.14.1) (cypiid6) (p450-db1) (debrisoquine 4-hydroxylase). [swissprot;acc:p10635]	Divided	219.354	224.7	1.02437
	sestrin 1 (p53-regulated protein pa26). [swissprot;acc:q9y6p5]	Subtracted	218.368	213.22	5.148
1259	pleckstrin homology domain containing, family c (with ferm domain) member 1; mitogen inducible 2; kindlin 2. [refseq;acc:nm_006832]	Divided	219.354	224.7	1.02437
	signal transducer and activator of transcription 5a. [swissprot;acc:p42229]	Subtracted	222.546	227.673	5.127
1260	lim and senescent cell antigen-like domains 2; ilk-binding protein. [refseq;acc:nm_017980]	Divided	219.354	224.7	1.02437
	signal transducer and activator of transcription 5b. [swissprot;acc:p51692]	Subtracted	222.544	227.667	5.123
1261	d(4) dopamine receptor (d(2c) dopamine receptor). [swissprot;acc:p21917]	Divided	219.354	224.7	1.02437
	t-complex protein 1, epsilon subunit (tcp-1-epsilon) (cct-epsilon). [swissprot;acc:p48643]	Subtracted	163.24	168.359	5.119
1262	keratin associated protein 9.2. [refseq;acc:nm_031961]	Divided	219.353	224.678	1.02428
	probable dimethyladenosine transferase (ec 2.1.1.-) (s- adenosylmethionine-6-n',n'-adenosyl(rrna) dimethyltransferase) (18s rrna dimethylase). [swissprot;acc:q9unq2]	Subtracted	226.347	221.259	5.088
1263	mitogen-activated protein kinase 12 (ec 2.7.1.37) (extracellular signal-regulated kinase 6) (erk-6) (erk5) (stress-activated protein kinase-3) (mitogen-activated protein kinase p38 gamma) (map kinase p38 gamma). [swissprot;acc:p53778]	Divided	171.231	167.177	1.02425
	putative phosphoglycerate mutase 3 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13). [swissprot;acc:q8n0y7]	Subtracted	212.724	207.637	5.087
1264	phosphoglycerate mutase 1 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme b) (pgam-b) (bpg-dependent pgam 1). [swissprot;acc:p18669]
	sphingosine kinase 1 (ec 2.7.1.-) (sk 1) (spk 1). [swissprot;acc:q9nya1]	Divided	171.231	167.177	1.02425
1265	phosphoglycerate mutase 2 (ec 5.4.2.1) (ec 5.4.2.4) (ec 3.1.3.13) (phosphoglycerate mutase isozyme m) (pgam-m) (bpg-dependent pgam 2) (muscle-specific phosphoglycerate mutase). [swissprot;acc:p15259]	Subtracted	212.724	207.637	5.087

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.