MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

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Showing element 1325 to 1374 of 16578 in total

Value Type  : Ranked
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	Interaction Map	red	network_comparison	green
amp deaminase 2 (ec 3.5.4.6) (amp deaminase isoform l). [swissprot;acc:q01433]	52	Divided	AMPD2	High confidence	133	1.26667	105
	167	Subtracted				28
	799	Divided		Low confidence	201.294	1.02643	196.11
	812	Subtracted				5.184
amphiphysin. [swissprot;acc:p49418]	2332		AMPH		202.089	3.673	198.416
	2389	Divided				1.01851
amyloid beta a4 precursor protein-binding family a member 1 (neuron- specific x11 protein) (neuronal munc18-1-interacting protein 1) (mint-1) (adapter protein x11alpha). [swissprot;acc:q02410]	61	Subtracted	APBA1		229.144	20.341	208.803
	79	Divided				1.09742
	97	Subtracted		High confidence	271.752	46.072	225.68
	139	Divided				1.20415
amyloid beta a4 protein precursor (app) (abpp) (alzheimer's disease amyloid protein) (cerebral vascular amyloid peptide) (cvap) (protease nexin-ii) (pn-ii) (appi) (prea4) [contains: soluble app-alpha (s-app- alpha); soluble app-beta (s-app-beta); c99; beta-amyloid protein 42 (beta-app42); beta-amyloid protein 40 (beta-app40); c83; p3(42); p3(40); gamma-ctf(59) (gamma-secretase c-terminal fragment 59) (amyloid intracellular domain 59) (aid(59)); gamma-ctf(57) (gamma- secretase c-terminal fragment 57) (amyloid intracellular domain 57) (aid(57)); gamma-ctf(50) (gamma-secretase c-terminal fragment 50) (amyloid intracellular domain 50) (aid(50)); c31]. [swissprot;acc:p05067]	505	Subtracted	APP	Low confidence	205.157	6.442	198.715
	508	Divided				1.03242
amyloid beta precursor protein-binding protein 1; amyloid protein-binding protein 1. [refseq;acc:nm_003905]	810		APPBP1		196.326	1.02627	191.3
	875	Subtracted				5.026
	2490	Divided		High confidence	194.527	1.00284	195.08
	2501	Subtracted				0.553
amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail)-binding protein 2; protein interacting with app tail 1. [refseq;acc:nm_006380]	3191	Divided	APPBP2		0.00001	1	0.00001
		Subtracted			0	0	0
	3369			Low confidence	200.658	3.051	197.607
	3371	Divided				1.01544
amyloid-like protein 1 precursor (aplp) (aplp-1) [contains: c30]. [swissprot;acc:p51693]	509	Subtracted	APLP1		205.157	6.442	198.715
	512	Divided				1.03242
amyloid-like protein 2 precursor (amyloid protein homolog) (apph) (cdei-box binding protein) (cdebp). [swissprot;acc:q06481]	515	Subtracted	APLP2		205.156	6.441
	518	Divided				1.03241
anaphase promoting complex subunit 11 (hepatocellular carcinoma associated ring finger protein) (hspc214). [swissprot;acc:q9nyg5]	2636		ANAPC11	High confidence	195.635	1.00128	195.384
	2639	Subtracted				0.251
	4080			Low confidence	202.978	2.197	200.781
	4090	Divided				1.01094
anaphase-promoting complex 1 (meiotic checkpoint regulator). [refseq;acc:nm_022662]	4764		ANAPC1		200.161	1.00492	201.146
	4765	Subtracted				0.985
anaphase-promoting complex subunit 10; anaphase-promoting complex 10. [refseq;acc:nm_014885]	200		ANAPC10		213.495	10.251	203.244
	207	Divided				1.05044
	2663			High confidence	204.768	1.00107	204.549
	2667	Subtracted				0.219
anaphase-promoting complex subunit 2; anaphase-promoting complex 2. [refseq;acc:nm_013366]	2679	Divided	ANAPC2		190.142	1.00096	189.959
	2682	Subtracted				0.183
	4572			Low confidence	202.548	1.538	204.086
	4577	Divided				1.00759
anchor attachment protein 1; glycophosphatidylinositol anchor attachment 1; anchor attachment protein 1 (gaa1p, yeast) homolog. [refseq;acc:nm_003801]	1646	Subtracted	no value		200.535	4.067	196.468
	1649	Divided				1.0207
androgen receptor coactivator ara55; hic-5. [refseq;acc:nm_015927]	2821	Subtracted	TGFB1I1		204.222	3.414	200.808
	2926	Divided				1.017
androgen-induced 1; cgi-103 protein; androgen induced protein. [refseq;acc:nm_016108]	184	Subtracted	AIG1	High confidence	227.357	26.793	254.15
	240	Divided				1.11785
	1206	Subtracted		Low confidence	204.026	4.511	199.515
	1254	Divided				1.02261
androgen-regulated short-chain dehydrogenase/reductase 1; prostate short-chain dehydrogenase reductase 1; cgi-82 protein; hcv core-binding protein; likely ortholog of mouse cell line mc/9.il4 derived transcript 1; likely ortholog of mouse prostate short-chain steroid dehydrogenase/reductase 1; retinol dehydrogenase 11. [refseq;acc:nm_016026]	3132		RDH11		200.082	1.01639	196.855
	3152	Subtracted				3.227
angiomotin like 2; leman coiled-coil protein; angiomotin-like protein 2. [refseq;acc:nm_016201]	2586	Divided	AMOTL2	High confidence	213.422	1.00154	213.75
		Subtracted				0.328

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.