MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 3232 to 3281 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	description	Interaction Map	red	green	network_comparison
1616	n-acetylglutamate synthase. [refseq;acc:nm_153006]	High confidence	223.179	226.611	1.01538
1617	ras-related protein rap-2a. [swissprot;acc:p10114]	Low confidence	202.026	197.9	1.02085
	serine hydroxymethyltransferase, cytosolic (ec 2.1.2.1) (serine methylase) (glycine hydroxymethyltransferase) (shmt). [swissprot;acc:p34896]	High confidence	221.045	217.699	1.01537
1618	rap2c, member of ras oncogene family. [refseq;acc:nm_021183]	Low confidence	202.026	197.9	1.02085
	transcription elongation factor a protein 2 (transcription elongation factor s-ii protein 2) (testis-specific s-ii) (transcription elongation factor tfiis.l). [swissprot;acc:q15560]	High confidence	227.768	231.246	1.01527
1619	ctf18, chromosome transmission fidelity factor 18 homolog; homolog of yeast chl12. [refseq;acc:nm_022092]	Low confidence	200.714	196.617	1.02084
	transcription elongation factor a protein 1 (transcription elongation factor s-ii protein 1) (transcription elongation factor tfiis.o). [swissprot;acc:p23193]	High confidence	227.768	231.246	1.01527
1620	adam-ts related protein 1 isoform 1; adam-ts related protein 1; thrombospondin; punctin. [refseq;acc:nm_139238]	Low confidence	203.893	199.732	1.02083
	transcription initiation factor iib (general transcription factor tfiib) (s300-ii). [swissprot;acc:q00403]	High confidence	228.611	225.185	1.01521
1621	follicular variant translocation protein 1 precursor (fvt-1). [swissprot;acc:q06136]	Low confidence	199.312	195.248	1.02081
	thyroid receptor interacting protein 3 (trip-3) (fragment). [swissprot;acc:q15649]	High confidence	228.611	225.185	1.01521
1622	helicase ski2w (helicase-like protein) (hlp). [swissprot;acc:q15477]	Low confidence	206.949	202.732	1.0208
	nhp2-like protein 1 (high mobility group-like nuclear protein 2 homolog 1) ([u4/u6.u5] tri-snrnp 15.5 kda protein) (otk27). [swissprot;acc:p55769]	High confidence	228.611	225.185	1.01521
1623	adam-tsl3 precursor (fragment). [sptrembl;acc:p82987]	Low confidence	203.903	199.748	1.0208
	nuclear fragile x mental retardation protein interacting protein 1; nuclear fragile x mental retardation intercating protein 1; nuclear fragile x mental retardation protein-interacting protein 1. [refseq;acc:nm_012345]	High confidence	228.611	225.185	1.01521
1624	asparaginyl-trna synthetase, cytoplasmic (ec 6.1.1.22) (asparagine-- trna ligase) (asnrs). [swissprot;acc:o43776]	Low confidence	201.291	197.189	1.0208
	rrp5 protein homolog (programmed cell death protein 11). [swissprot;acc:q14690]	High confidence	230.643	227.194	1.01518
1625	c18b11 homolog (44.9kd). [refseq;acc:nm_152260]		217.446	214.2	1.01515
	protein bap28. [swissprot;acc:q9h583]	Low confidence	202.298	198.176	1.0208
1626	fk506-binding protein 6 (ec 5.2.1.8) (peptidyl-prolyl cis-trans isomerase) (ppiase) (rotamase) (36 kda fk506 binding protein) (fkbp- 36) (immunophilin fkbp36). [swissprot;acc:o75344]		205.372	201.187
	z-protein (protein cgi-119) (s1r protein). [swissprot;acc:q9hc24]	High confidence	217.446	214.2	1.01515
1627	epsin 3. [refseq;acc:nm_017957]	Low confidence	190.847	186.958	1.0208
	pp1201 protein. [refseq;acc:nm_022152]	High confidence	217.446	214.2	1.01515
1628	alpha adducin (erythrocyte adducin alpha subunit). [swissprot;acc:p35611]	Low confidence	205.76	201.569	1.02079
	lifeguard; kiaa0950 protein. [refseq;acc:nm_012306]	High confidence	217.446	214.2	1.01515
1629	dnaj homolog subfamily a member 1 (heat shock 40 kda protein 4) (dnaj protein homolog 2) (hsj-2) (hsdj). [swissprot;acc:p31689]	Low confidence	197.458	193.436	1.02079
	sterol regulatory element binding protein-2 (srebp-2) (sterol regulatory element-binding transcription factor 2). [swissprot;acc:q12772]	High confidence	217.446	214.2	1.01515
1630	40s ribosomal protein s17. [swissprot;acc:p08708]	Low confidence	204.428	200.265	1.02079
	sterol regulatory element binding protein-1 (srebp-1) (sterol regulatory element-binding transcription factor 1). [swissprot;acc:p36956]	High confidence	217.446	214.2	1.01515
1631	carnitine o-palmitoyltransferase i, mitochondrial muscle isoform (ec 2.3.1.21) (cpt i) (cpti-m) (carnitine palmitoyltransferase i like protein). [swissprot;acc:q92523]	Low confidence	199.793	195.725	1.02078
	g1 to s phase transition protein 1 homolog (gtp-binding protein gst1-hs). [swissprot;acc:p15170]	High confidence	218.789	215.533	1.01511
1632	isocitrate dehydrogenase [nadp], mitochondrial precursor (ec 1.1.1.42) (oxalosuccinate decarboxylase) (idh) (nadp+-specific icdh) (idp) (icd-m). [swissprot;acc:p48735]	Low confidence	192.879	188.955	1.02077
	mitotic checkpoint protein bub3. [swissprot;acc:o43684]	High confidence	221.934	218.658	1.01498
1633	zinc binding alcohol dehydrogenase, domain containing 1. [refseq;acc:nm_152444]	Low confidence	197.514	193.498	1.02075
	zinc finger protein 207. [swissprot;acc:o43670]	High confidence	221.934	218.658	1.01498
1634	glycylpeptide n-tetradecanoyltransferase 1 (ec 2.3.1.97) (peptide n- myristoyltransferase 1) (myristoyl-coa:protein n-myristoyltransferase 1) (nmt 1) (type i n-myristoyltransferase). [swissprot;acc:p30419]	Low confidence	200.654	196.575	1.02075
	malonyl-coa decarboxylase, mitochondrial precursor (ec 4.1.1.9) (mcd). [swissprot;acc:o95822]	High confidence	215.772	212.596	1.01494
1635	itchy homolog e3 ubiquitin protein ligase; atrophin-1 interacting protein 4; itchy (mouse homolog) e3 ubiquitin protein ligase; nfe2-associated polypeptide 1; ubiquitin protein ligase itch. [refseq;acc:nm_031483]
	peroxiredoxin 5, mitochondrial precursor (prx-v) (peroxisomal antioxidant enzyme) (plp) (thioredoxin peroxidase pmp20) (antioxidant enzyme b166) (aoeb166) (tpx type vi) (liver tissue 2d-page spot 71b) (alu co-repressor 1) (sbbi10). [swissprot;acc:p30044]	Low confidence	201.901	197.797	1.02075
1636	beclin 1 (coiled-coil myosin-like bcl2-interacting protein) (protein gt197). [swissprot;acc:q14457]	High confidence	202.358	199.408	1.01479
	gtp-binding protein rad (ras associated with diabetes) (rad1). [swissprot;acc:p55042]	Low confidence	202.784	198.663	1.02074
1637	26s protease regulatory subunit 8 (proteasome subunit p45) (thyroid hormone receptor interacting protein 1) (trip1) (msug1 protein) (tat-binding protein homolog 10) (tbp10) (p45/sug). [swissprot;acc:p47210]	High confidence	202.358	199.408	1.01479
	gtp-binding protein gem (gtp-binding mitogen-induced t-cell protein) (ras-like protein kir). [swissprot;acc:p55040]	Low confidence	202.784	198.663	1.02074
1638	alpha-1-acid glycoprotein 2 precursor (agp 2) (orosomucoid 2) (omd 2). [swissprot;acc:p19652]		203.742	199.603
	serine hydroxymethyltransferase, mitochondrial precursor (ec 2.1.2.1) (serine methylase) (glycine hydroxymethyltransferase) (shmt). [swissprot;acc:p34897]	High confidence	220.686	217.481	1.01474
1639	ras (rad and gem)-like gtp-binding; gtpase ges; rem protein. [refseq;acc:nm_014012]	Low confidence	202.784	198.663	1.02074
	yl-1 protein (transcription factor-like 1). [swissprot;acc:q15906]	High confidence	194.516	197.364	1.01464
1640	adapter-related protein complex 3 mu 2 subunit (clathrin coat assembly protein ap47 homolog 2) (clathrin coat associated protein ap47 homolog 2) (golgi adaptor ap-1 47 kda protein homolog 2) (ha1 47 kda subunit homolog 2) (clathrin assembly protein assembly protein complex 1 medium chain homolog 2) (p47b). [swissprot;acc:p53677]	Low confidence	202.787	198.666	1.02074
	hydroxyacylglutathione hydrolase (ec 3.1.2.6) (glyoxalase ii) (glx ii). [swissprot;acc:q16775]	High confidence	194.516	197.364	1.01464
1641	adapter-related protein complex 3 mu 1 subunit (mu-adaptin 3a) (ap-3 adapter complex mu3a subunit). [swissprot;acc:q9y2t2]	Low confidence	202.78	198.661	1.02073

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.