MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	Value Type	Network Comparison Type	description	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1301 to 1350 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

Rank	Hugo	Network Comparison Type	description	red	green	network_comparison
651	BAIAP3	Divided	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]	233.725	220.751	1.05877
	GABRG3	Subtracted	gamma-aminobutyric-acid receptor gamma-3 subunit precursor (gaba(a) receptor). [swissprot;acc:q99928]	214.256	202.139	12.117
652	no value	Divided	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]	248.994	235.255	1.0584
	FOXG1	Subtracted	forkhead box protein g1c (forkhead-related protein fkhl3) (hfk3) (fragment). [swissprot;acc:q14488]	214.256	202.139	12.117
653	no value	Divided	dok-like protein. [refseq;acc:nm_024872]	216.504	204.622	1.05807
		Subtracted	interleukin-1 receptor-associated kinase 4; interleukin-1 receptor associated kinase 4. [refseq;acc:nm_016123]	214.256	202.139	12.117
654	DOK2	Divided	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	216.504	204.622	1.05807
	JMJD6	Subtracted	phosphatidylserine receptor; phosphatidylserine receptor beta. [refseq;acc:nm_015167]	214.256	202.139	12.117
655	DOK1	Divided	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	216.504	204.622	1.05807
	GABRG1	Subtracted	gamma-aminobutyric-acid receptor gamma-1 subunit precursor (gaba(a) receptor). [swissprot;acc:q8n1c3]	214.256	202.14	12.116
656	FRK	Divided	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	216.504	204.622	1.05807
	GABRA2	Subtracted	gamma-aminobutyric-acid receptor alpha-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p47869]	214.256	202.14	12.116
657	GABRA6		gamma-aminobutyric-acid receptor alpha-6 subunit precursor (gaba(a) receptor). [swissprot;acc:q16445]
	SYN3	Divided	synapsin iii. [swissprot;acc:o14994]	229.072	216.576	1.0577
658	no value		aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	GABRG2	Subtracted	gamma-aminobutyric-acid receptor gamma-2 subunit precursor (gaba(a) receptor). [swissprot;acc:p18507]	214.256	202.14	12.116
659	GABRA4		gamma-aminobutyric-acid receptor alpha-4 subunit precursor (gaba(a) receptor). [swissprot;acc:p48169]
	HEY1	Divided	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	229.072	216.576	1.0577
660	ABLIM2		actin binding lim protein 2. [refseq;acc:nm_032432]
	GABRE	Subtracted	gamma-aminobutyric-acid receptor epsilon subunit precursor (gaba(a) receptor). [swissprot;acc:p78334]	214.256	202.14	12.116
661	GABRA1		gamma-aminobutyric-acid receptor alpha-1 subunit precursor (gaba(a) receptor). [swissprot;acc:p14867]
	HEYL	Divided	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	229.072	216.576	1.0577
662	GABRA3	Subtracted	gamma-aminobutyric-acid receptor alpha-3 subunit precursor (gaba(a) receptor). [swissprot;acc:p34903]	214.256	202.14	12.116
	SYN2	Divided	synapsin ii. [swissprot;acc:q92777]	229.072	216.576	1.0577
663	MRRF		mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]
	NDUFA6	Subtracted	nadh-ubiquinone oxidoreductase b14 subunit (ec 1.6.5.3) (ec 1.6.99.3) (complex i-b14) (ci-b14). [swissprot;acc:p56556]	214.256	202.141	12.115
664	PDXDC1		similar to expressed sequence aa415817. [sptrembl;acc:q8n4q9]
	PEX5	Divided	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]	229.072	216.576	1.0577
665	HEY2		hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]
	HOXD9	Subtracted	homeobox protein hox-d9 (hox-4c) (hox-5.2). [swissprot;acc:p28356]	214.254	202.166	12.088
666	EIF3I		eukaryotic translation initiation factor 3 subunit 2 (eif-3 beta) (eif3 p36) (eif3i) (tgf-beta receptor interacting protein 1) (trip-1). [swissprot;acc:q13347]	250.465	238.38	12.085
	HES1	Divided	transcription factor hes-1 (hairy and enhancer of split 1) (hairy- like) (hhl) (hairy homolog). [swissprot;acc:q14469]	229.072	216.576	1.0577
667	no value	Subtracted	trinucleotide repeat containing 15. [refseq;acc:nm_015575]	250.465	238.38	12.085
	ECH1	Divided	delta3,5-delta2,4-dienoyl-coa isomerase, mitochondrial precursor (ec 5.3.3.-). [swissprot;acc:q13011]	229.072	216.576	1.0577
668	ABLIM1		actin-binding lim protein 1 isoform a; lim actin-binding protein 1; limatin; actin-binding lim protein. [refseq;acc:nm_002313]
	FTSJ3	Subtracted	ftsj homolog 3; likely ortholog of mouse ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 3. [refseq;acc:nm_017647]	244.495	232.419	12.076
669	no value		presenilin-like protein 2 (ec 3.4.99.-) (sppl2a protein). [swissprot;acc:q8tct8]	232.601	244.534	11.933
	SYN1	Divided	synapsin i (brain protein 4.1). [swissprot;acc:p17600]	229.072	216.576	1.0577
670	GNL2		autoantigen ngp-1. [swissprot;acc:q13823]	250.302	236.817	1.05694
	RANP1	Subtracted	gtp-binding nuclear protein ran (tc4) (ran gtpase) (androgen receptor- associated protein 24). [swissprot;acc:p17080]	232.601	244.534	11.933
671	no value		presenilin-like protein 1 (ec 3.4.99.-) (sppl2b protein). [swissprot;acc:q8tct7]
	NUBP1	Divided	nucleotide-binding protein 1 (nbp 1). [swissprot;acc:p53384]	210.739	199.398	1.05688
672	no value	Subtracted	dok-like protein. [refseq;acc:nm_024872]	216.504	204.622	11.882
	NUBP2	Divided	nucleotide binding protein 2 (nbp 2). [swissprot;acc:q9y5y2]	210.739	199.398	1.05688
673	CASK		peripheral plasma membrane protein cask (ec 2.7.1.-) (hcask) (calcium/calmodulin-dependent serine protein kinase) (lin-2 homolog). [swissprot;acc:o14936]	226.497	214.355	1.05664
	DOK2	Subtracted	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	216.504	204.622	11.882
674	DOK1		docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]
	HIF3A	Divided	hypoxia-inducible factor-3 alpha isoform a; inhibitory pas domain protein. [refseq;acc:nm_152794]	226.497	214.355	1.05664
675	FRK	Subtracted	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	216.504	204.622	11.882
	SIM1	Divided	single-minded homolog 1. [swissprot;acc:p81133]	226.497	214.355	1.05664

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.