MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Value Type	Hugo	description	Interaction Map	network_comparison	Filtered	red	green

Results: HTML CSV LaTeX

Showing element 12864 to 12913 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Value Type	Hugo	description	Interaction Map	network_comparison	red	green
1608	Rooted	SFRS10	arginine/serine-rich splicing factor 10 (transformer-2-beta) (htra2- beta) (transformer 2 protein homolog) (silica-induced protein 41) (ra301). [swissprot;acc:q15815]	Low confidence	1.0361	71.6531	74.2401
1609	Measured	HSF4	heat shock factor protein 4 (hsf 4) (heat shock transcription factor 4) (hstf 4) (hhsf4). [swissprot;acc:q9ulv5]		1.0336	8141.75	8415.33
		PSMD10	26s proteasome non-atpase regulatory subunit 10 (26s proteasome regulatory subunit p28) (gankyrin). [swissprot;acc:o75832]	High confidence	1.07134	5826.74	6242.44
	Ranked	DUSP13	dual specificity protein phosphatase 13 (ec 3.1.3.48) (ec 3.1.3.16) (testis- and skeletal-muscle-specific dsp). [swissprot;acc:q9uii6]	Low confidence	1.02088	199.691	195.607
		UGP2	utp--glucose-1-phosphate uridylyltransferase 2 (ec 2.7.7.9) (udp- glucose pyrophosphorylase 2) (udpgp 2) (ugpase 2). [swissprot;acc:q16851]	High confidence	1.0158	208.113	204.876
	Squared	C20orf4	protein c20orf4 (protein cgi-23) (pro0225). [swissprot;acc:q9y312]	Low confidence	1.04277	46189.9	44295.3
		WTAP	wilms' tumor 1-associating protein (wt1-associated protein). [swissprot;acc:q15007]	High confidence	1.10876	28992.5	32145.6
	Rooted	PSMB5	proteasome subunit beta type 5 precursor (ec 3.4.25.1) (proteasome epsilon chain) (macropain epsilon chain) (multicatalytic endopeptidase complex epsilon chain) (proteasome subunit x) (proteasome chain 6) (proteasome subunit mb1). [swissprot;acc:p28074]		1.03494	65.5919	67.884
		SFRS6	splicing factor, arginine/serine-rich 6 (pre-mrna splicing factor srp55). [swissprot;acc:q13247]	Low confidence	1.0361	71.6217	74.2075
1610	Measured	EIF5A2	eif-5a2 protein. [refseq;acc:nm_020390]	High confidence	1.07126	6222.4	6665.83
		IKBKAP	ikappab kinase complex-associated protein (ikk complex-associated protein) (p150). [swissprot;acc:o95163]	Low confidence	1.0336	7843.41	8106.95
	Ranked	MUS81	mus81 endonuclease. [refseq;acc:nm_025128]		1.02087	195.31	191.317
		UBE2V2	ubiquitin-conjugating enzyme e2 variant 2; 1 alpha,25-dihydroxyvitamin d3-inducible; enterocyte differentiation promoting factor; methyl methanesulfonate sensitive 2, s. cerevisiae, homolog of. [refseq;acc:nm_003350]	High confidence	1.01579	208.122	204.886
	Squared	KRR1	hiv-1 rev binding protein 2; rev interacting protein. [refseq;acc:nm_007043]		1.10866	15639.2	17338.5
		SORCS2	vps10 domain-containing receptor sorcs2 precursor. [swissprot;acc:q96pq0]	Low confidence	1.04276	51308.3	49204.2
	Rooted	SFRS4	splicing factor, arginine/serine-rich 4 (pre-mrna splicing factor srp75) (srp001lb). [swissprot;acc:q08170]		1.0361	71.6217	74.2075
		SLC5A5	sodium/iodide cotransporter (na(+)/i(-) cotransporter) (sodium-iodide symporter) (na+/i-symporter). [swissprot;acc:q92911]	High confidence	1.03489	67.4766	69.831
1611	Measured	CDC25A	m-phase inducer phosphatase 1 (ec 3.1.3.48) (dual specificity phosphatase cdc25a). [swissprot;acc:p30304]	Low confidence	1.03359	7703.86	7962.64
		TRIP10	cdc42-interacting protein 4 (thyroid receptor interacting protein 10) (trip-10). [swissprot;acc:q15642]	High confidence	1.07119	5497.73	5132.35
	Ranked	CEP70	p10-binding protein. [refseq;acc:nm_024491]		1.01577	221.313	217.877
		FAM119A	similar to hepatocellular carcinoma-associated antigen hca557b. [refseq;acc:nm_145280]	Low confidence	1.02087	195.31	191.317
	Squared	no value	heat shock factor binding protein 1. [swissprot;acc:o75506]	High confidence	1.10865	27263.5	30225.7
		SORCS3	vps10 domain-containing receptor sorcs3 precursor. [swissprot;acc:q9upu3]	Low confidence	1.04276	51308.3	49204.2
	Rooted	BOLA2B	my016 protein. [sptrembl;acc:q9h3k6]		1.03609	73.8923	76.5593
		PRODH2	kidney and liver proline oxidase 1. [refseq;acc:nm_021232]	High confidence	1.03486	67.4958	69.8487
1612	Measured	no value	zinc finger protein 277. [swissprot;acc:q9nrm2]	Low confidence	1.03358	7691.32	7949.57
		EIF5AP1	eukaryotic translation initiation factor 5a (eif-5a) (eif-4d) (rev- binding factor). [swissprot;acc:p10159]	High confidence	1.07116	6212.98	6655.12
	Ranked	no value	enthoprotin; epsin 4; clathrin interacting protein localized in the trans-golgi region. [refseq;acc:nm_014666]		1.0157	221.426	224.902
		FAM119B	hepatocellularcarcinoma-associated antigen hca557a. [refseq;acc:nm_015433]	Low confidence	1.02087	195.31	191.317
	Squared	no value	brain protein 16. [refseq;acc:nm_016458]	High confidence	1.10845	26202.2	29043.8
		SORL1	sortilin-related receptor precursor (sorting protein-related receptor containing ldlr class a repeats) (sorla) (sorla-1) (low-density lipoprotein receptor relative with 11 ligand-binding repeats) (ldlr relative with 11 ligand-binding repeats) (lr11). [swissprot;acc:q92673]	Low confidence	1.04276	51308.3	49204.2
	Rooted	SF1	splicing factor 1; zinc finger protein 162. [refseq;acc:nm_004630]		1.03609	72.2859	74.8944
		SLC5A8	solute carrier family 5 (iodide transporter), member 8; apical iodide transporter. [refseq;acc:nm_145913]	High confidence	1.03485	67.5045	69.8568
1613	Measured	IGF2BP1	igf-ii mrna-binding protein 1. [refseq;acc:nm_006546]	Low confidence	1.03356	7815.17	8077.42
		MRPS22	mitochondrial 28s ribosomal protein s22 (s22mt) (mrp-s22) (gk002). [swissprot;acc:p82650]	High confidence	1.07106	6035.6	6464.5
	Ranked	GTPBP3	mitochondrial gtp binding protein isoform v. [refseq;acc:nm_032620]	Low confidence	1.02086	192.787	188.847
		HTATIP2	hiv-1 tat interactive protein 2, 30kda; tat-interacting protein (30kd); hiv-1 tat interactive protein 2, 30 kda; hiv-1 tat interactive protein 2, 30 kd. [refseq;acc:nm_006410]	High confidence	1.0157	182.378	185.241
	Squared	NETO2	neuropilin- and tolloid-like protein 2 precursor. [refseq;acc:nm_018092]		1.10834	15399.5	17067.9
		SORCS1	vps10 domain-containing receptor sorcs1 precursor (hsorcs). [swissprot;acc:q8wy21]	Low confidence	1.04276	51308.3	49204.2
	Rooted	MRPL39	mitochondrial 39s ribosomal protein l39 (l39mt) (mrp-l39) (mrp-l5) (pred22 protein). [swissprot;acc:q9nyk5]		1.03609	69.7446	72.2614
		SLC5A6	sodium-dependent multivitamin transporter (na(+)-dependent multivitamin transporter). [swissprot;acc:q9y289]	High confidence	1.03484	67.511	69.8628
1614	Measured	no value	nefa-interacting nuclear protein nip30. [refseq;acc:nm_024946]		1.07106	6035.6	6464.5
		RAB5A	ras-related protein rab-5a. [swissprot;acc:p20339]	Low confidence	1.03356	7968.53	8235.92
	Ranked	FOXA2	hepatocyte nuclear factor 3-beta (hnf-3b) (forkhead box protein a2). [swissprot;acc:q9y261]	High confidence	1.0156	217.233	213.897
		RAP2B	ras-related protein rap-2b. [swissprot;acc:p17964]	Low confidence	1.02085	202.026	197.9
	Squared	no value	suppressor of ty 5 homolog; suppressor of ty (s.cerevisiae) 5 homolog. [refseq;acc:nm_003169]		1.04276	43732.3	41938.9
		NETO1	neuropilin- and tolloid-like protein 1 isoform 3 precursor. [refseq;acc:nm_138966]	High confidence	1.10834	15399.5	17067.9
	Rooted	ADD3	gamma adducin (adducin-like protein 70). [swissprot;acc:q9uey8]	Low confidence	1.03609	70.2663	72.8023
		PDSS1	trans-prenyltransferase; polyprenyl pyrophosphate synthetase. [refseq;acc:nm_014317]	High confidence	1.03482	54.1932	56.0802
1615	Measured	LMX1A	lim homeobox transcription factor 1 alpha (lim/homeobox protein lmx1a) (lim-homeobox protein 1.1) (lmx-1.1). [swissprot;acc:q8te12]		1.07106	6035.6	6464.5

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.