MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Value Type	Hugo	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1280 to 1329 of 1660 in total

Value Type  : Ranked
Hugo  : no value
Filtered  : 1

description	Rank	Network Comparison Type	Interaction Map	red	network_comparison	green
serine/threonine protein phosphatase 2a, 55 kda regulatory subunit b, alpha isoform (pp2a, subunit b, b-alpha isoform) (pp2a, subunit b, b55-alpha isoform) (pp2a, subunit b, pr55-alpha isoform) (pp2a, subunit b, r2-alpha isoform). [swissprot;acc:q00007]	3924	Subtracted	Low confidence	199.187	2.495	196.692
serpin b11. [swissprot;acc:q96p15]	761		High confidence	224.244	10.267	234.511
	795	Divided			1.04578
	3797	Subtracted	Low confidence	202.443	2.656	199.787
	3799	Divided			1.01329
seven in absentia homolog 1. [refseq;acc:nm_003031]	2186	Subtracted	High confidence	223.608	1.397	225.005
	2234	Divided			1.00625
	4178		Low confidence	202.646	1.01037	200.567
	4185	Subtracted			2.079
sh2 domain binding protein 1; tpr-containing, sh2-binding phosphoprotein. [refseq;acc:nm_014633]	662			206.115	5.653	200.462
	681	Divided			1.0282
	924	Subtracted	High confidence	238.725	7.666	231.059
	1004	Divided			1.03318
sh3 adapter protein spin90 (sh3 protein interacting with nck, 90 kda) (vaca-interacting protein, 54 kda) (vip54) (af3p21) (diaphanous protein interacting protein) (dia interacting protein-1) (dip-1). [swissprot;acc:q9nzq3]	2867			0.00001	1	0.00001
		Subtracted		0	0	0
	4881		Low confidence	205.789	0.483	205.306
	4887	Divided			1.00235
sh3 domain-binding glutamic acid-rich-like protein 2 (fovea-associated sh3 domain binding protein). [swissprot;acc:q9ujc5]	2037	Subtracted	High confidence	218.79	1.809	216.981
	2058	Divided			1.00834
	4113		Low confidence	202.688	1.0107	200.543
	4116	Subtracted			2.145
signal recognition particle receptor alpha subunit (sr-alpha) (docking protein alpha) (dp-alpha). [swissprot;acc:p08240]	1148		High confidence	224.878	5.536	219.342
	1208	Divided			1.02524
	2980	Subtracted	Low confidence	201.258	3.308	197.95
	3010	Divided			1.01671
signal-induced proliferation-associated 1-like 1. [refseq;acc:nm_015556]	2141	Subtracted	High confidence	215.925	1.444	214.481
	2164	Divided			1.00673
	2519	Subtracted	Low confidence	201.54	3.574	197.966
	2556	Divided			1.01805
similar to peptidylprolyl isomerase a (cyclophilin a); cyclophilin-lc; cyclophilin homolog overexpressed in liver cancer; chromosome 1 amplified sequence 2. [refseq;acc:nm_178230]	3238	Subtracted		204.389	3.151	201.238
	3295	Divided			1.01566
similar to phosphatidylinositol 4-kinase, catalytic, alpha polypeptide. [sptrembl;acc:q8wuk7]	1830			200.699	1.01998	196.767
	1845	Subtracted			3.932
similar to ribosomal protein, large, p0. [sptrembl;acc:q96fq9]	1020		High confidence	226.218	6.662	232.88
	1090	Divided			1.02945
	3896	Subtracted	Low confidence	202.201	2.526	199.675
	3899	Divided			1.01265
similar to rna polymerase i transcription factor rrn3. [refseq;acc:nm_145237]	3517			201.1	1.01483	198.161
	3518	Subtracted			2.939
similar to zinc finger protein 136. [refseq;acc:nm_145295]	4319	Divided		197.793	1.00934	195.963
	4337	Subtracted			1.83
similar to zinc finger protein 20 (zinc finger protein kox13) (dkfzp572p0920). [refseq;acc:nm_145233]	4347	Divided			1.00934
	4366	Subtracted			1.83
similar to zinc finger protein 277. [sptrembl;acc:q8wwa6]	988		High confidence	236.679	7	243.679
	1086	Divided			1.02958
	2287	Subtracted	Low confidence	204.169	3.689	200.48
	2427	Divided			1.0184
similar to zinc finger protein 85 (zinc finger protein hpf4) (htf1). [refseq;acc:nm_033196]	4410			197.793	1.00934	195.963
	4429	Subtracted			1.83
sirtuin 7; sir2-related protein type 7; sirtuin type 7; sirtuin (silent mating type information regulation 2, s.cerevisiae, homolog) 7; silent mating type information regulation 2, s.cerevisiae, homolog 7; sirtuin silent mating type information regulation 2 homolog 7 (s. cerevisiae). [refseq;acc:nm_016538]	399			205.017	7.154	197.863

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.