MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1280 to 1329 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	1283	no value	Low confidence	205.134	200.628	1.02246
casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	863	CSNK2A1P	High confidence	240.194	230.957	1.03999
	1396		Low confidence	203.987	199.614	1.02191
casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	864	CSNK2A2	High confidence	240.194	230.957	1.03999
	1344		Low confidence	204.058	199.639	1.02213
caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	1292	CASP7	High confidence	233.942	228.46	1.024
	3278		Low confidence	200.06	196.969	1.01569
caspr5 protein isoform 1. [refseq;acc:nm_130773]	2096	CNTNAP5		208.784	204.84	1.01925
catalase (ec 1.11.1.6). [swissprot;acc:p04040]	3162	CAT		200.833	197.631	1.0162
catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	1834	CTNNAL1	High confidence	180.409	182.459	1.01136
	2169		Low confidence	199.004	195.281	1.01906
cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	826	CTSB		201.026	195.916	1.02608
	1667		High confidence	214.898	211.898	1.01416
cathepsin d precursor (ec 3.4.23.5). [swissprot;acc:p07339]	1653	CTSD	Low confidence	200.398	196.334	1.0207
cathepsin f precursor (ec 3.4.22.41) (catsf). [swissprot;acc:q9ubx1]	3383	CTSF		197.398	194.412	1.01536
cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	156	CTSL1		211.808	199.761	1.06031
	1426		High confidence	214.717	219.157	1.02068
cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	155	CTSL2	Low confidence	211.818	199.734	1.0605
	1425		High confidence	214.717	219.157	1.02068
cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	151	CTSZ	Low confidence	206.516	194.554	1.06148
cationic amino acid transporter-4 (cat-4) (cat4). [swissprot;acc:o43246]	1059	SLC7A4		200.552	195.852	1.024
caveolin-1. [swissprot;acc:q03135]	2948	CAV1		203.908	200.509	1.01695
	3099		High confidence	0.00001	0.00001	1
caveolin-3 (m-caveolin). [swissprot;acc:p56539]	2779	CAV3
	2945		Low confidence	203.908	200.509	1.01695
cbf1 interacting corepressor. [refseq;acc:nm_004882]	572	no value	High confidence	227.86	213.945	1.06504
	1317		Low confidence	203.649	199.217	1.02225
cbl e3 ubiquitin protein ligase (ec 6.3.2.-) (signal transduction protein cbl) (proto-oncogene c-cbl). [swissprot;acc:p22681]	762	CBL	High confidence	213.256	203.237	1.0493
	2808		Low confidence	201.49	198.065	1.01729
ccaat displacement protein (cdp) (cut-like 1). [swissprot;acc:p39880]	556	CUTL1	High confidence	207.27	194.368	1.06638
	927		Low confidence	198.264	193.42	1.02504
ccaat-binding transcription factor subunit b (cbf-b) (nf-y protein chain a) (nf-ya) (caat-box dna binding protein subunit a). [swissprot;acc:p23511]	36	NFYA	High confidence	260.532	204.309	1.27519
	232		Low confidence	214.032	204.284	1.04772
ccaat-box-binding transcription factor (ccaat-binding factor) (cbf). [swissprot;acc:q03701]	408	CEBPZ	High confidence	255.112	234.804	1.08649
	581		Low confidence	205.428	199.293	1.03078
ccr4-not transcription complex, subunit 3; not3 (negative regulator of transcription 3, yeast) homolog. [refseq;acc:nm_014516]	2949	CNOT3		203.908	200.509	1.01695
	3163		High confidence	0.00001	0.00001	1
ccr4-not transcription complex, subunit 4; not4 (negative regulator of transcription 4, yeast) homolog; ccr4-not transcription complex, subunit. [refseq;acc:nm_013316]	1390	CNOT4		218.47	213.875	1.02148
	2422		Low confidence	201.298	197.652	1.01845
ccr4-not transcription complex, subunit 6-like. [refseq;acc:nm_144571]	2958	CNOT6L	High confidence	0.00001	0.00001	1
	4214		Low confidence	196.65	194.692	1.01006
ccr4-not transcription complex, subunit 7 (ccr4-associated factor 1) (caf1) (btg1 binding factor 1). [swissprot;acc:q9uiv1]	1238	no value		202.15	197.664	1.0227
	3226		High confidence	0.00001	0.00001	1
ccr4-not transcription complex, subunit 8 (caf1-like protein) (califp). [swissprot;acc:q9uff9]	1247	CNOT8	Low confidence	202.14	197.663	1.02265
	2890		High confidence	0.00001	0.00001	1
cd109; gov system alloantigens on platelets. [refseq;acc:nm_133493]	1206	CD109	Low confidence	203.629	208.303	1.02295
	2075		High confidence	221.703	223.483	1.00803
cd209 antigen-like; putative type ii membrane protein. [refseq;acc:nm_014257]	418	CLEC4M		233.539	253.197	1.08417
	4590		Low confidence	204.076	202.598	1.0073
cd209 antigen; dendritic cell-specific icam3-grabbing nonintegrin. [refseq;acc:nm_021155]	420	CD209	High confidence	233.539	253.197	1.08417

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.