MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1280 to 1329 of 8289 in total

Value Type  : Ranked
Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Interaction Map	red	green	network_comparison
640	MEGF6	megf6 (fragment). [sptrembl;acc:o75095]	Low confidence	207.235	201.402	1.02896
641	PRAM1	pram-1 protein; pml-rara target gene encoding an adaptor molecule-1. [refseq;acc:nm_032152]	High confidence	217.67	230.596	1.05938
	RABEP1	rabaptin, rab gtpase binding effector protein 1; rabaptin-5; neurocrescin. [refseq;acc:nm_004703]	Low confidence	198.493	192.907	1.02896
642	no value	intersectin 2 (sh3 domain-containing protein 1b) (sh3p18) (sh3p18-like wasp associated protein). [swissprot;acc:q9nzm3]	High confidence	217.67	230.596	1.05938
	CUL2	cullin homolog 2 (cul-2). [swissprot;acc:q13617]	Low confidence	203.883	198.148	1.02894
643	HEMK1	hemk protein homolog (ec 2.1.1.-) (m.hsahemkp). [swissprot;acc:q9y5r4]		203.104	197.399	1.0289
	HRBL	hiv-1 rev binding protein-like; rev/rex activation domain binding protein-related. [refseq;acc:nm_006076]	High confidence	217.67	230.596	1.05938
644	C16orf35	cgthba protein (-14 gene protein). [swissprot;acc:q12980]
	GULP1	ptb domain adaptor protein ced-6; engulfment adapter protein. [refseq;acc:nm_016315]	Low confidence	203.911	198.193	1.02885
645	HTATSF1	hiv tat specific factor 1; cofactor required for tat activation of hiv-1 transcription. [refseq;acc:nm_014500]	High confidence	217.67	230.596	1.05938
	PDIA2	protein disulfide isomerase a2 precursor (ec 5.3.4.1) (pdip). [swissprot;acc:q13087]	Low confidence	204.488	198.765	1.02879
646	BTF3L1	transcription factor btf3 homolog 1. [swissprot;acc:q13890]		204.634	198.914	1.02876
	SCOC	short coiled-coil protein; short coiled coil protein. [refseq;acc:nm_032547]	High confidence	216.731	229.549	1.05914
647	ARFGEF1	brefeldin a-inhibited guanine nucleotide-exchange protein 1 (brefeldin a-inhibited gep 1) (p200 arf-gep1) (p200 arf guanine nucleotide exchange factor). [swissprot;acc:q9y6d6]	Low confidence	203.293	197.621	1.0287
	DYNLL2	dynein light chain 2. [refseq;acc:nm_080677]	High confidence	216.731	229.549	1.05914
648	ALDH3B1	aldehyde dehydrogenase 7 (ec 1.2.1.5). [swissprot;acc:p43353]	Low confidence	210.325	216.359	1.02869
	MARS	methionyl-trna synthetase (ec 6.1.1.10) (methionine--trna ligase) (metrs). [swissprot;acc:p56192]	High confidence	218.227	206.078	1.05895
649	ARFGEF2	brefeldin a-inhibited guanine nucleotide-exchange protein 2 (brefeldin a-inhibited gep 2). [swissprot;acc:q9y6d5]	Low confidence	203.283	197.617	1.02867
	EIF4E	eukaryotic translation initiation factor 4e (eif-4e) (eif4e) (mrna cap-binding protein) (eif-4f 25 kda subunit). [swissprot;acc:p06730]	High confidence	233.725	220.751	1.05877
650	no value	u6 snrna-associated sm-like protein lsm7. [swissprot;acc:q9uk45]		228.986	216.276
	MARCH6	similar to s. cerevisiae ssm4. [refseq;acc:nm_005885]	Low confidence	207.662	201.876	1.02866
651	no value	large proline-rich protein bat3 (hla-b-associated transcript 3) (g3). [swissprot;acc:p46379]
	BAIAP3	bai1-associated protein 3; bai-associated protein 3. [refseq;acc:nm_003933]	High confidence	233.725	220.751	1.05877
652	no value	tgf beta-inducible nuclear protein 1; hairy cell leukemia protein 1. [refseq;acc:nm_014886]		248.994	235.255	1.0584
	ZNF593	zinc finger protein t86. [swissprot;acc:o00488]	Low confidence	205.897	200.163	1.02865
653	no value	dok-like protein. [refseq;acc:nm_024872]	High confidence	216.504	204.622	1.05807
	DHODH	dihydroorotate dehydrogenase, mitochondrial precursor (ec 1.3.3.1) (dihydroorotate oxidase) (dhodehase) (fragment). [swissprot;acc:q02127]	Low confidence	203.975	198.304	1.0286
654	DOK2	docking protein 2 (p56(dok-2)) (downstream of tyrosine kinase 2). [swissprot;acc:o60496]	High confidence	216.504	204.622	1.05807
	ZEB2	zinc finger homeobox protein 1b (smad interacting protein 1) (smadip1) (hrihfb2411). [swissprot;acc:o60315]	Low confidence	205.995	200.27	1.02859
655	DOK1	docking protein 1 (p62(dok)) (downstream of tyrosine kinase 1) (pp62). [swissprot;acc:q99704]	High confidence	216.504	204.622	1.05807
	ZEB1	transcription factor 8 (nil-2-a zinc finger protein) (negative regulator of il2). [swissprot;acc:p37275]	Low confidence	205.995	200.27	1.02859
656	FRK	tyrosine-protein kinase frk (ec 2.7.1.112) (nuclear tyrosine protein kinase rak). [swissprot;acc:p42685]	High confidence	216.504	204.622	1.05807
	ITGB2	integrin beta-2 precursor (cell surface adhesion glycoproteins lfa- 1/cr3/p150,95 beta-subunit) (cd18) (complement receptor c3 beta- subunit). [swissprot;acc:p05107]	Low confidence	206.339	200.608	1.02857
657	ITGB7	integrin beta-7 precursor. [swissprot;acc:p26010]		206.341	200.609
	SYN3	synapsin iii. [swissprot;acc:o14994]	High confidence	229.072	216.576	1.0577
658	no value	aspartate beta-hydroxylase isoform b; junctin isoform 1; junctate; aspartyl/asparaginyl-beta-hydroxylase; peptide-aspartate beta-dioxygenase; humbug. [refseq;acc:nm_032468]
	ITGB3	integrin beta-3 precursor (platelet membrane glycoprotein iiia) (gpiiia) (cd61 antigen). [swissprot;acc:p05106]	Low confidence	206.342	200.61	1.02857
659	HEY1	hairy/enhancer-of-split related with yrpw motif 1 (hairy and enhancer of split related-1) (hesr-1) (cardiovascular helix-loop-helix factor 2) (hes-related repressor protein 2 herp2). [swissprot;acc:q9y5j3]	High confidence	229.072	216.576	1.0577
	TP53I3	tumor protein p53 inducible protein 3; quinone oxidoreductase homolog; p53-induced gene 3 protein. [refseq;acc:nm_004881]	Low confidence	175.504	170.633	1.02855
660	ABLIM2	actin binding lim protein 2. [refseq;acc:nm_032432]	High confidence	229.072	216.576	1.0577
	ITGA7	integrin alpha-7 precursor. [swissprot;acc:q13683]	Low confidence	206.32	200.601	1.02851
661	HEYL	hairy/enhancer-of-split related with yrpw motif-like. [refseq;acc:nm_014571]	High confidence	229.072	216.576	1.0577
	SOS1	son of sevenless protein homolog 1 (sos-1). [swissprot;acc:q07889]	Low confidence	200.62	195.059	1.02851
662	ITGA6	integrin alpha-6 precursor (vla-6) (cd49f). [swissprot;acc:p23229]		206.321	200.601
	SYN2	synapsin ii. [swissprot;acc:q92777]	High confidence	229.072	216.576	1.0577
663	ITGA3	integrin alpha-3 precursor (galactoprotein b3) (gapb3) (vla-3 alpha chain) (cd49c). [swissprot;acc:p26006]	Low confidence	206.32	200.601	1.02851
	MRRF	mitochondrial ribosome recycling factor. [refseq;acc:nm_138777]	High confidence	229.072	216.576	1.0577
664	PEX5	peroxisomal targeting signal 1 receptor (peroxismore receptor 1) (peroxisomal c-terminal targeting signal import receptor) (pts1-bp) (peroxin-5) (pts1 receptor). [swissprot;acc:p50542]
	PRPF31	pre-mrna processing factor 31 homolog; pre-mrna processing factor 31 homolog (yeast). [refseq;acc:nm_015629]	Low confidence	201.821	196.233	1.02848
665	HEY2	hairy/enhancer-of-split related with yrpw motif 2; gridlock; hes-related repressor protein 1. [refseq;acc:nm_012259]	High confidence	229.072	216.576	1.0577

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.