MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Network Comparison Type	Gene	Value Type	Hugo	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1280 to 1329 of 6456 in total

Value Type  : Ranked
Interaction Map  : High confidence
Filtered  : 1

description	Rank	Network Comparison Type	Hugo	red	network_comparison	green
copper-transporting atpase 2 (ec 3.6.3.4) (copper pump 2) (wilson disease-associated protein). [swissprot;acc:p35670]	2354	Divided	ATP7B	215.078	1.00434	214.148
coproporphyrinogen iii oxidase, mitochondrial precursor (ec 1.3.3.3) (coproporphyrinogenase) (coprogen oxidase) (cox). [swissprot;acc:p36551]	2617		CPOX	202.821	1.00139	202.54
	2632	Subtracted			0.281
core-binding factor, beta subunit (cbf-beta) (polyomavirus enhancer binding protein 2 beta subunit) (pebp2-beta) (pea2-beta) (sl3-3 enhancer factor 1 beta subunit) (sl3/akv core-binding factor beta subunit). [swissprot;acc:q13951]	3183	Divided	CBFB	0.00001	1	0.00001
		Subtracted		0	0	0
cox15 homolog isoform 2 precursor; cytochrome c oxidase subunit 15; cytochrome c oxidase assembly protein. [refseq;acc:nm_004376]	1513	Divided	COX15	213.268	1.01794	209.509
	1523	Subtracted			3.759
cpg binding protein (protein containing phd finger and cxxc domain 1). [swissprot;acc:q9p0u4]	1136		CXXC1	219.399	5.615	213.784
	1168	Divided			1.02626
cpz gene product. [refseq;acc:nm_003652]	690	Subtracted	CPZ	223.121	11.436	211.685
	716	Divided			1.05402
creatine kinase, b chain (ec 2.7.3.2) (b-ck). [swissprot;acc:p12277]	1940		CKB	198.19	1.00988	196.252
	1998	Subtracted			1.938
creatine kinase, m chain (ec 2.7.3.2) (m-ck). [swissprot;acc:p06732]	1971	Divided	CKM	198.258	1.00974	196.346
	2001	Subtracted			1.912
creatine kinase, sarcomeric mitochondrial precursor (ec 2.7.3.2) (s- mtck) (mib-ck) (basic-type mitochondrial creatine kinase). [swissprot;acc:p17540]	1936	Divided	CKMT2	198.3	1.00995	196.347
	1993	Subtracted			1.953
creatine kinase, ubiquitous mitochondrial precursor (ec 2.7.3.2) (u- mtck) (mia-ck) (acidic-type mitochondrial creatine kinase). [swissprot;acc:p12532]	1938	Divided	no value	198.293	1.00994	196.341
	1994	Subtracted			1.952
crk-associated substrate (p130cas) (breast cancer anti-estrogen resistance 1 protein). [swissprot;acc:p56945]	284	Divided	BCAR1	224.657	1.10541	203.235
	330	Subtracted			21.422
crk-like protein. [swissprot;acc:p46109]	552	Divided	CRKL	207.26	1.06645	194.346
	599	Subtracted			12.914
crooked neck-like protein 1 (crooked neck homolog) (hcrn) (cgi-201) (mstp021). [swissprot;acc:q9bzj0]	564	Divided	CRNKL1	220.744	1.06577	207.121
	566	Subtracted			13.623
ctcl tumor antigen l14-2. [refseq;acc:nm_018017]	2846	Divided	C10orf118	0.00001	1	0.00001
		Subtracted		0	0	0
ctp synthase (ec 6.3.4.2) (utp--ammonia ligase) (ctp synthetase). [swissprot;acc:p17812]	1755	Divided	CTPS	180.609	1.01242	178.393
	1885	Subtracted			2.216
cug triplet repeat rna-binding protein 1 (cug-bp1) (rna-binding protein brunol-2) (deadenylation factor cug-bp) (50 kda nuclear polyadenylated rna-binding protein) (eden-bp). [swissprot;acc:q92879]	1778		CUGBP1	217.984	2.543	215.441
	1801	Divided			1.0118
cug triplet repeat, rna binding protein 2; elav-type rna-binding protein; cug triplet repeat,rna-binding protein 2; cug triplet repeat, rna-binding protein 2; neuroblastoma apoptosis-related rna-binding protein. [refseq;acc:nm_006561]	1780	Subtracted	CUGBP2		2.542	215.442
	1804	Divided			1.0118
cullin homolog 1 (cul-1). [swissprot;acc:q13616]	129	Subtracted	CUL1	285.684	33.45	252.234
	212	Divided			1.13261
cullin homolog 2 (cul-2). [swissprot;acc:q13617]	127	Subtracted	CUL2		33.45
	210	Divided			1.13261
cyclic-amp-dependent transcription factor atf-2 (activating transcription factor 2) (camp response element binding protein cre- bp1) (hb16). [swissprot;acc:p15336]	1357	Subtracted	ATF2	218.657	4.547	214.11
	1401	Divided			1.02124
cyclic-amp-dependent transcription factor atf-3 (activating transcription factor 3). [swissprot;acc:p18847]	28		ATF3	201.949	1.31416	153.671
	96	Subtracted			48.278
cyclic-amp-dependent transcription factor atf-6 alpha (activating transcription factor 6 alpha) (atf6-alpha). [swissprot;acc:p18850]	1669		ATF6	216.899	3.01	213.889
	1683	Divided			1.01407
cyclic-amp-dependent transcription factor atf-6 beta (activating transcription factor 6 beta) (atf6-beta) (camp responsive element binding protein-like 1) (camp response element binding protein-related protein) (creb-rp) (g13 protein). [swissprot;acc:q99941]	1666	Subtracted	CREBL1		3.01
	1680	Divided			1.01407
cyclic-amp-dependent transcription factor atf-7 (activating transcription factor 7) (transcription factor atf-a). [swissprot;acc:p17544]	1356	Subtracted	ATF7	218.667	4.549	214.118
	1400	Divided			1.02125
cyclin c. [swissprot;acc:p24863]	1794	Subtracted	CCNC	217.071	2.507	214.564
	1812	Divided			1.01168
cyclin g1 (cyclin g). [swissprot;acc:p51959]	963		CCNG1	130.066	1.0343	134.527

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.