MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Network Comparison Type	Hugo	Value Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1275 to 1324 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Network Comparison Type	Hugo	Value Type	red	network_comparison	green
160	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Divided	GNAO1	Ranked	249.663	1.19466	298.263
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		no value	Squared	173408	1.40126	242989
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	Subtracted	KCNIP1	Rooted	43.4291	11.7132	31.7159
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Divided	MAGED1	Measured	23693.7	1.29736	18263
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	Subtracted	NEUROD6	Ranked	312	28	284
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]		CCT3	Squared	42788.3	17374.3	60162.6
161	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Divided	HOXB4		173408	1.40126	242989
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		MAGEF1	Measured	23693.7	1.29736	18263
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	Subtracted	MYH13		9035	1755.4	7279.6
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]		NEUROD1	Ranked	312	28	284
	ns1-associated protein 1. [refseq;acc:nm_006372]	Divided	SYNCRIP	Rooted	52.7642	1.17318	61.9019
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	Subtracted	KCNIP4		43.4519	11.6997	31.7522
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Divided	RAP1GAP	Ranked	249.663	1.19466	298.263
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	Subtracted	TRMU	Squared	52591.3	17253.8	69845.1
162	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]		no value	Ranked	142	28	170
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Divided	HNRNPR	Rooted	52.7642	1.17318	61.9019
	high-mobility group 20a. [refseq;acc:nm_018200]	Subtracted	HMG20A	Measured	5140.14	1753.39	6893.53
	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Divided	HOXC5	Squared	173408	1.40126	242989
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	Subtracted	KCNIP2	Rooted	43.4554	11.6978	31.7576
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Divided	MAGEB6B	Measured	23693.7	1.29736	18263
	nostrin. [refseq;acc:nm_052946]		NOSTRIN	Ranked	209.299	1.19058	249.187
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	Subtracted	CLEC11A	Squared	59704	16756.4	76460.4
163	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]		NCBP2	Rooted	54.935	11.6751	66.6101
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]		ARRB2	Ranked	133	28	105
	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]		CLEC3A	Squared	59464	16656.8	76120.8
	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Divided	SNF8	Ranked	209.299	1.19058	249.187
	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]		EIF4G1	Rooted	52.7702	1.17285	61.8915
	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		no value	Squared	173408	1.40126	242989
	likely ortholog of mouse variant polyadenylation protein cstf-64. [refseq;acc:nm_015235]	Subtracted	CSTF2T	Measured	14976.4	1729.8	13246.6
	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Divided	no value		23693.7	1.29736	18263
164	1,4-alpha-glucan branching enzyme (ec 2.4.1.18) (glycogen branching enzyme) (brancher enzyme). [swissprot;acc:q04446]	Subtracted	GBE1		4489.19	1723.37	2765.82
	beta-arrestin 1 (arrestin, beta 1). [swissprot;acc:p49407]		ARRB1	Ranked	133	28	105
	deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor (ec 3.6.1.23) (dutpase) (dutp pyrophosphatase). [swissprot;acc:p33316]		DUT	Squared	61733.5	16509.4	45224.1
	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	Divided	HOXD4		173408	1.40126	242989
	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]		SLC39A6	Ranked	209.299	1.19058	249.187
	mad protein (max dimerizer). [swissprot;acc:q05195]		MXD1	Rooted	55.646	1.17086	65.1534
	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		MAGEA9	Measured	23693.7	1.29736	18263
	musashi 2 isoform a. [refseq;acc:nm_138962]	Subtracted	MSI2	Rooted	54.9787	11.2629	66.2416
165	glutamate decarboxylase, 65 kda isoform (ec 4.1.1.15) (gad-65) (65 kda glutamic acid decarboxylase). [swissprot;acc:q05329]	Divided	GAD2	Ranked	209.299	1.19058	249.187
	glycogen phosphorylase, brain form (ec 2.4.1.1). [swissprot;acc:p11216]	Subtracted	PYGB	Measured	4489.19	1723.37	2765.82
	homeobox protein hox-b5 (hox-2a) (hho.c10) (hu-1). [swissprot;acc:p09067]	Divided	HOXB5	Squared	173408	1.40126	242989
	max interacting protein 1 (mxi1 protein). [swissprot;acc:p50539]		MXI1	Rooted	55.6486	1.1707	65.1478
	melanoma-associated antigen 8 (mage-8 antigen). [swissprot;acc:p43361]		MAGEA8	Measured	23693.7	1.29736	18263
	musashi 1. [refseq;acc:nm_002442]	Subtracted	MSI1	Rooted	54.9787	11.2629	66.2416
	spermatogenesis associated 6. [refseq;acc:nm_019073]		SPATA6	Ranked	133	28	105
	tetranectin precursor (tn) (plasminogen-kringle 4 binding protein). [swissprot;acc:p05452]		CLEC3B	Squared	59016.1	16470.8	75486.9
166	c-terminal binding protein 2 (ctbp2). [swissprot;acc:p56545]		CTBP2		69201.8	16188.4	53013.4
	gamma-soluble nsf attachment protein (snap-gamma) (n-ethylmaleimide- sensitive factor attachment protein, gamma). [swissprot;acc:q99747]	Divided	NAPG	Ranked	209.299	1.19058	249.187
	glycogen phosphorylase, liver form (ec 2.4.1.1). [swissprot;acc:p06737]	Subtracted	PYGL	Measured	4489.19	1723.37	2765.82
	homeobox protein hox-a5 (hox-1c). [swissprot;acc:p20719]	Divided	HOXA5	Squared	173408	1.40126	242989

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.