MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Network Comparison Type	Hugo	Value Type	description	Interaction Map	Filtered	network_comparison	red	green

Results: HTML CSV LaTeX

Showing element 1263 to 1312 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	Value Type	description	Interaction Map	network_comparison	red	green
158	STRN	Rooted	striatin. [swissprot;acc:o43815]	Low confidence	1.06851	66.4354	70.987
	WDR33	Squared	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]		1.12381	57732.3	51372.1
159	no value	Rooted	rna-binding protein. [refseq;acc:nm_019027]	High confidence	1.17318	52.7642	61.9019
			transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]	Low confidence	1.06818	65.5823	70.0536
	BRP44	Measured	brain protein 44. [swissprot;acc:o95563]		1.08349	10392.1	11259.7
	GGNBP2	Ranked	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]		1.05988	219.838	207.417
	HINT1	Squared	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]		1.12001	22187.9	19810.5
	NDN	Measured	necdin. [swissprot;acc:q99608]	High confidence	1.29736	23693.7	18263
	RGS17	Ranked	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]		1.19466	249.663	298.263
	SEPT6	Squared	septin 6. [swissprot;acc:q14141]		1.40359	88953.6	124854
160	no value		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]		1.40126	173408	242989
		Rooted	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]		1.17318	52.7642	61.9019
	APC	Ranked	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Low confidence	1.0595	222.31	235.538
	DCHS1	Rooted	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]		1.06801	65.7817	70.2555
	GNAO1	Ranked	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	High confidence	1.19466	249.663	298.263
	MAGED1	Measured	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]		1.29736	23693.7	18263
	MTHFR		methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898]	Low confidence	1.08304	10452.8	11320.8
	PCSK5	Squared	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]		1.11969	54208.6	48413.8
161	APC2	Ranked	adenomatous polyposis coli like. [refseq;acc:nm_005883]		1.0594	222.34	235.547
	HOXB4	Squared	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	High confidence	1.40126	173408	242989
	MAGEF1	Measured	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]		1.29736	23693.7	18263
	PBLD	Squared	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	Low confidence	1.11893	60522.9	67721
	RAP1GAP	Ranked	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	High confidence	1.19466	249.663	298.263
	SLC15A2	Rooted	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Low confidence	1.06801	70.5717	75.371
	SLC16A5	Measured	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]		1.08298	10351.8	11210.8
	SYNCRIP	Rooted	ns1-associated protein 1. [refseq;acc:nm_006372]	High confidence	1.17318	52.7642	61.9019
162	DAD1	Ranked	defender against cell death 1 (dad-1). [swissprot;acc:p46966]	Low confidence	1.05926	197.99	186.913
	GABARAP	Squared	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]		1.11854	53479.8	47812.1
	HNRNPR	Rooted	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	High confidence	1.17318	52.7642	61.9019
	HOXC5	Squared	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]		1.40126	173408	242989
	MAGEB6B	Measured	melanoma antigen, family b, 6. [refseq;acc:nm_173523]		1.29736	23693.7	18263
	NOSTRIN	Ranked	nostrin. [refseq;acc:nm_052946]		1.19058	209.299	249.187
	PSCD1	Measured	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Low confidence	1.08298	12424.3	11472.3
	SEPT8	Rooted	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]		1.06796	98.7481	105.459
163	no value	Measured	melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	High confidence	1.29736	23693.7	18263
		Squared	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]		1.40126	173408	242989
	CPSF1		cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	Low confidence	1.11847	56828	50808.5
	EIF4G1	Rooted	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	High confidence	1.17285	52.7702	61.8915
	SLC16A1	Measured	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Low confidence	1.08293	10348.5	11206.7
	SNF8	Ranked	eap30 subunit of ell complex. [refseq;acc:nm_007241]	High confidence	1.19058	209.299	249.187
	STRN4	Rooted	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	Low confidence	1.06757	66.5155	71.0097
	VPS41	Ranked	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]		1.05907	202.698	191.393
164	BACH1	Squared	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]		1.11844	37094.3	41487.9
	HOXD4		homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]	High confidence	1.40126	173408	242989
	MAGEA9	Measured	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]		1.29736	23693.7	18263
	MXD1	Rooted	mad protein (max dimerizer). [swissprot;acc:q05195]		1.17086	55.646	65.1534
	PPM1B	Ranked	protein phosphatase 2c beta isoform (ec 3.1.3.16) (pp2c-beta). [swissprot;acc:o75688]	Low confidence	1.05898	196.714	185.758
	SEPT10	Rooted	septin 10 isoform 1. [refseq;acc:nm_144710]		1.06735	98.1106	104.718
	SLC16A7	Measured	monocarboxylate transporter 2 (mct 2). [swissprot;acc:o60669]		1.08291	10346.9	11204.8
	SLC39A6	Ranked	liv-1 protein, estrogen regulated. [refseq;acc:nm_012319]	High confidence	1.19058	209.299	249.187

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.