MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Hugo	description	Value Type	Network Comparison Type	Interaction Map	Filtered	red	network_comparison	green

Results: HTML CSV LaTeX

Showing element 1258 to 1307 of 33156 in total

Network Comparison Type  : Divided
Filtered  : 1

Rank	Hugo	description	Value Type	Interaction Map	red	network_comparison	green
158	DNAJC8	dnaj homolog subfamily c member 8 (splicing protein spf31) (hspc315). [swissprot;acc:o75937]	Ranked	Low confidence	219.838	1.05988	207.417
	GPSM2	mosaic protein lgn. [swissprot;acc:p81274]		High confidence	249.663	1.19466	298.263
	MAGEA6	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	Measured		23693.7	1.29736	18263
	MTUS1	mitochondrial tumor suppressor gene 1; transcription factor mtsg1; at2 receptor-interacting protein 1; erythroid differentiation-related gene. [refseq;acc:nm_020749]		Low confidence	6434.71	1.08416	6976.28
	SEPT7	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	Squared	High confidence	89182.8	1.40418	125229
	STRN	striatin. [swissprot;acc:o43815]	Rooted	Low confidence	66.4354	1.06851	70.987
	WDR33	wd-repeat protein wdc146. [swissprot;acc:q9c0j8]	Squared		57732.3	1.12381	51372.1
159	no value	rna-binding protein. [refseq;acc:nm_019027]	Rooted	High confidence	52.7642	1.17318	61.9019
		transgelin 2 (sm22-alpha homolog). [swissprot;acc:p37802]		Low confidence	65.5823	1.06818	70.0536
	BRP44	brain protein 44. [swissprot;acc:o95563]	Measured		10392.1	1.08349	11259.7
	GGNBP2	c3hc4-type zinc finger protein; likely ortholog of mouse dioxin inducible factor 3. [refseq;acc:nm_024835]	Ranked		219.838	1.05988	207.417
	HINT1	histidine triad nucleotide-binding protein 1 (adenosine 5'- monophosphoramidase) (protein kinase c inhibitor 1) (protein kinase c- interacting protein 1) (pkci-1). [swissprot;acc:p49773]	Squared		22187.9	1.12001	19810.5
	NDN	necdin. [swissprot;acc:q99608]	Measured	High confidence	23693.7	1.29736	18263
	RGS17	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	Ranked		249.663	1.19466	298.263
	SEPT6	septin 6. [swissprot;acc:q14141]	Squared		88953.6	1.40359	124854
160	no value	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]	Rooted		52.7642	1.17318	61.9019
		homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	Squared		173408	1.40126	242989
	APC	adenomatous polyposis coli protein (apc protein). [swissprot;acc:p25054]	Ranked	Low confidence	222.31	1.0595	235.538
	DCHS1	protocadherin 16 precursor (cadherin 19) (cadherin fibroblast 1). [swissprot;acc:q96jq0]	Rooted		65.7817	1.06801	70.2555
	GNAO1	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	Ranked	High confidence	249.663	1.19466	298.263
	MAGED1	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	Measured		23693.7	1.29736	18263
	MTHFR	methylenetetrahydrofolate reductase (ec 1.5.1.20). [swissprot;acc:p42898]		Low confidence	10452.8	1.08304	11320.8
	PCSK5	proprotein convertase subtilisin/kexin type 5 precursor (ec 3.4.21.-) (proprotein convertase pc5) (subtilisin/kexin-like protease pc5) (convertase pc5) (pc6) (hpc6). [swissprot;acc:q92824]	Squared		54208.6	1.11969	48413.8
161	APC2	adenomatous polyposis coli like. [refseq;acc:nm_005883]	Ranked		222.34	1.0594	235.547
	HOXB4	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	Squared	High confidence	173408	1.40126	242989
	MAGEF1	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	Measured		23693.7	1.29736	18263
	PBLD	mawd binding protein (unknown protein 32 from 2d-page of liver tissue). [swissprot;acc:p30039]	Squared	Low confidence	60522.9	1.11893	67721
	RAP1GAP	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	Ranked	High confidence	249.663	1.19466	298.263
	SLC15A2	oligopeptide transporter, kidney isoform (peptide transporter 2) (kidney h+/peptide cotransporter) (solute carrier family 15, member 2). [swissprot;acc:q16348]	Rooted	Low confidence	70.5717	1.06801	75.371
	SLC16A5	monocarboxylate transporter 6 (mct 6) (mct 5). [swissprot;acc:o15375]	Measured		10351.8	1.08298	11210.8
	SYNCRIP	ns1-associated protein 1. [refseq;acc:nm_006372]	Rooted	High confidence	52.7642	1.17318	61.9019
162	DAD1	defender against cell death 1 (dad-1). [swissprot;acc:p46966]	Ranked	Low confidence	197.99	1.05926	186.913
	GABARAP	gaba(a) receptor-associated protein; gaba(a)-receptor-associated protein. [refseq;acc:nm_007278]	Squared		53479.8	1.11854	47812.1
	HNRNPR	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	Rooted	High confidence	52.7642	1.17318	61.9019
	HOXC5	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	Squared		173408	1.40126	242989
	MAGEB6B	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	Measured		23693.7	1.29736	18263
	NOSTRIN	nostrin. [refseq;acc:nm_052946]	Ranked		209.299	1.19058	249.187
	PSCD1	cytohesin 1 (sec7 homolog b2-1). [swissprot;acc:q15438]	Measured	Low confidence	12424.3	1.08298	11472.3
	SEPT8	septin-like protein kiaa0202 (fragment). [swissprot;acc:q92599]	Rooted		98.7481	1.06796	105.459
163	no value	homeobox protein hox-c6 (hox-3c) (hho.c8) (cp25). [swissprot;acc:p09630]	Squared	High confidence	173408	1.40126	242989
		melanoma-associated antigen 4 (mage-4 antigen) (mage-x2) (mage-41). [swissprot;acc:p43358]	Measured		23693.7	1.29736	18263
	CPSF1	cleavage and polyadenylation specificity factor, 160 kda subunit (cpsf 160 kda subunit). [swissprot;acc:q10570]	Squared	Low confidence	56828	1.11847	50808.5
	EIF4G1	eukaryotic translation initiation factor 4 gamma (eif-4-gamma) (eif- 4g) (eif4g) (p220). [swissprot;acc:q04637]	Rooted	High confidence	52.7702	1.17285	61.8915
	SLC16A1	monocarboxylate transporter 1 (mct 1). [swissprot;acc:p53985]	Measured	Low confidence	10348.5	1.08293	11206.7
	SNF8	eap30 subunit of ell complex. [refseq;acc:nm_007241]	Ranked	High confidence	209.299	1.19058	249.187
	STRN4	striatin 4 (zinedin). [swissprot;acc:q9nrl3]	Rooted	Low confidence	66.5155	1.06757	71.0097
	VPS41	vacuolar assembly protein vps41 homolog (s53). [swissprot;acc:p49754]	Ranked		202.698	1.05907	191.393
164	BACH1	transcription regulator protein bach1 (btb and cnc homolog 1) (ha2303). [swissprot;acc:o14867]	Squared		37094.3	1.11844	41487.9
	HOXD4	homeobox protein hox-d4 (hox-4b) (hox-5.1) (hho.c13). [swissprot;acc:p09016]		High confidence	173408	1.40126	242989
	MAGEA9	melanoma-associated antigen 9 (mage-9 antigen). [swissprot;acc:p43362]	Measured		23693.7	1.29736	18263

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.