MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	Value Type	Filtered	red	Hugo	description	green	Interaction Map	network_comparison	Network Comparison Type

Results: HTML CSV LaTeX

Showing element 501 to 550 of 3228 in total

Value Type  : Ranked
Filtered  : 1
Interaction Map  : High confidence
Network Comparison Type  : Divided

Rank	red	Hugo	description	green	network_comparison
501	238.704	CYC1	cytochrome c1, heme protein, mitochondrial precursor (cytochrome c-1). [swissprot;acc:p08574]	255.68	1.07112
502		ARHGAP26	oligophrenin-1 like protein (gtpase regulator associated with focal adhesion kinase). [swissprot;acc:q9una1]
503		RGN	senescence marker protein-30 (smp-30) (regucalcin) (rc). [swissprot;acc:q15493]
504		OPHN1	oligophrenin 1. [swissprot;acc:o60890]
505	251.334	NOC3L	ad24 protein. [refseq;acc:nm_022451]	234.672	1.071
506	224.535	ING1	inhibitor of growth family, member 1; inhibitor of growth 1. [refseq;acc:nm_005537]	240.476
507	251.299	WDR12	wd-repeat protein 12 (ytm1 homolog). [swissprot;acc:q9gzl7]	234.729	1.07059
508	177.698	CPA3	mast cell carboxypeptidase a precursor (ec 3.4.17.1) (mc-cpa) (carboxypeptidase a3). [swissprot;acc:p15088]	190.24	1.07058
509		CPA6	carboxypeptidase b precursor. [refseq;acc:nm_020361]	190.239	1.07057
510	177.699	CPB2	plasma carboxypeptidase b2 isoform a preproprotein; carboxypeptidase u; thrombin-activatable fibrinolysis inhibitor; carboxypeptidase b-like protein; thrombin-activable fibrinolysis inhibitor. [refseq;acc:nm_001872]	190.24
511	250.053	NOL1	proliferating-cell nucleolar antigen p120 (proliferation-associated nucleolar protein p120). [swissprot;acc:p46087]	233.725	1.06986
512	250.794	BOP1	block of proliferation 1. [swissprot;acc:q14137]	234.433	1.06979
513	218.596	DVL1	segment polarity protein dishevelled homolog dvl-1 (dishevelled-1) (dsh homolog 1). [swissprot;acc:o14640]	204.344	1.06975
514	218.613	DVL2	segment polarity protein dishevelled homolog dvl-2 (dishevelled-2) (dsh homolog 2). [swissprot;acc:o14641]	204.382	1.06963
515	251.297	PES1	pescadillo homolog 1. [swissprot;acc:o00541]	234.941	1.06962
516	228.255	LSM8	u6 snrna-associated sm-like protein lsm8. [swissprot;acc:o95777]	213.422	1.0695
517	219.537	MTX2	metaxin 2. [swissprot;acc:o75431]	234.793	1.06949
518	250.858	GNL3	nucleostemin; putative nucleotide binding protein, estradiol-induced. [refseq;acc:nm_014366]	234.563	1.06947
519	218.702	DVL3	segment polarity protein dishevelled homolog dvl-3 (dishevelled-3) (dsh homolog 3). [swissprot;acc:q92997]	204.582	1.06902
520	214.754	SLC35D2	sqv-7-like protein (fragment). [sptrembl;acc:o95454]	229.565	1.06897
521	215.237	EXOSC4	exosome complex exonuclease rrp41 (ec 3.1.13.-) (ribosomal rna processing protein 41) (p12a). [swissprot;acc:q9npd3]	230.07	1.06891
522	222.893	PLRG1	pleiotropic regulator 1 (prl1homolog, arabidopsis); pleiotropic regulator 1 (prl1, arabidopsis homolog). [refseq;acc:nm_002669]	208.523
523	215.237	EXOSC2	exosome complex exonuclease rrp4 (ec 3.1.13.-) (ribosomal rna processing protein 4). [swissprot;acc:q13868]	230.07
524		EXOSC3	exosome complex exonuclease rrp40 (ec 3.1.13.-) (ribosomal rna processing protein 40) (p10) (cgi-102). [swissprot;acc:q9nqt5]
525		EXOSC5	exosome complex exonuclease rrp46 (ec 3.1.13.-) (ribosomal rna processing protein 46) (p12b) (chronic myelogenous leukemia tumor antigen 28). [swissprot;acc:q9nqt4]
526	250.538	RRP1	nnp-1 protein (novel nuclear protein 1) (nucleolar protein nop52) (nop52) (d21s2056e). [swissprot;acc:p56182]	234.401	1.06884
527	248.56	DDX31	dead (asp-glu-ala-asp) box polypeptide 31 isoform 1; dead/dexh helicase ddx31. [refseq;acc:nm_022779]	232.579	1.06871
528	222.146	YME1L1	yme1-like 1 isoform 3; atp-dependent metalloprotease ftsh1 homolog. [refseq;acc:nm_014263]	237.393	1.06864
529	251.653	DDX18	atp-dependent rna helicase ddx18 (dead-box protein 18) (myc-regulated dead-box protein) (mrdb). [swissprot;acc:q9nvp1]	235.506	1.06856
530	227.483	LSM6	u6 snrna-associated sm-like protein lsm6 (sm protein f). [swissprot;acc:q9y4y8]	212.994	1.06803
531	223.356	PRPF19	nuclear matrix protein nmp200 related to splicing factor prp19. [refseq;acc:nm_014502]	209.149	1.06793
532	250.942	ZNF622	zinc finger-like protein 9. [refseq;acc:nm_033414]	235.004	1.06782
533		SLC45A2	membrane-associated transporter protein (aim-1 protein) (melanoma antigen aim1). [swissprot;acc:q9umx9]
534		no value	guanine nucleotide-binding protein-like 1 (gtp-binding protein hsr1). [swissprot;acc:p36915]
535	236.662	POLR2H	dna-directed rna polymerases i, ii, and iii 17.1 kda polypeptide (ec 2.7.7.6) (rpb17) (rpb8) (rpabc3). [swissprot;acc:p52434]	252.708	1.0678
536	242.531	SSB	lupus la protein (sjogren syndrome type b antigen) (ss-b) (la ribonucleoprotein) (la autoantigen). [swissprot;acc:p05455]	227.136	1.06778
537	229.803	DHX15	putative pre-mrna splicing factor rna helicase (deah box protein 15) (atp-dependent rna helicase #46). [swissprot;acc:o43143]	215.301	1.06736
538	237.627	POLR2L	dna-directed rna polymerase ii 7.6 kda polypeptide (ec 2.7.7.6) (rpb10) (rpb7.6) (rpabc5). [swissprot;acc:p52436]	253.604	1.06724
539	236.964	MEMO1P	protein cgi-27 (c21orf19-like protein). [swissprot;acc:q9y316]	252.86	1.06708
540	222.156	SEPHS2	selenide,water dikinase 2 (ec 2.7.9.3) (selenophosphate synthetase 2) (selenium donor protein 2). [swissprot;acc:q99611]	208.201	1.06703
541		MICAL2	flavoprotein oxidoreductase mical2. [refseq;acc:nm_014632]
542		INPP4B	inositol polyphosphate-4-phosphatase, type ii, 105kd; inositol polyphosphate 4-phosphatase ii; 4-phosphatase ii. [refseq;acc:nm_003866]
543		SEPHS1	selenide,water dikinase 1 (ec 2.7.9.3) (selenophosphate synthetase 1) (selenium donor protein 1). [swissprot;acc:p49903]
544		INPP4A	inositol polyphosphate-4-phosphatase, type 1 isoform b; inositol polyphosphate-4-phosphatase, type i, 107kd; 4-phosphatase i; inositol polyphosphate-4-phosphatase i. [refseq;acc:nm_001566]
545	248.866	EIF6	eukaryotic translation initiation factor 6 (eif-6) (b4 integrin interactor) (cab) (p27(bbp)) (b(2)gcn homolog). [swissprot;acc:p56537]	233.287	1.06678
546	207.222	WAS	wiskott-aldrich syndrome protein (wasp). [swissprot;acc:p42768]	194.262	1.06671
547	207.26	CRK	proto-oncogene c-crk (p38) (adapter molecule crk). [swissprot;acc:p46108]	194.346	1.06645
548		ABL2	tyrosine-protein kinase abl2 (ec 2.7.1.112) (tyrosine kinase arg). [swissprot;acc:p42684]
549		no value	proto-oncogene tyrosine-protein kinase src (ec 2.7.1.112) (p60-src) (c-src). [swissprot;acc:p12931]
550		HCK	tyrosine-protein kinase hck (ec 2.7.1.112) (p59-hck/p60-hck) (hemopoietic cell kinase). [swissprot;acc:p08631]

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.