MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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Rank	Gene	description	Hugo	Network Comparison Type	Value Type	Interaction Map	red	Filtered	green	network_comparison

Results: HTML CSV LaTeX

Showing element 1251 to 1300 of 25824 in total

Interaction Map  : High confidence
Filtered  : 1

Rank	description	Hugo	Network Comparison Type	Value Type	red	green	network_comparison
157	hepatocellular carcinoma-associated protein hca1. [refseq;acc:nm_020932]	no value	Divided	Measured	23693.7	18263	1.29736
	huntingtin interacting protein 1 (hip-i). [swissprot;acc:o00291]	HIP1	Subtracted	Squared	76438	58889.7	17548.3
	huntingtin-interacting protein hypa/fbp11 (fragment). [sptrembl;acc:o75404]	no value		Rooted	55.1113	67.5537	12.4424
	myosin heavy chain, fast skeletal muscle, embryonic (muscle embryonic myosin heavy chain) (smhce). [swissprot;acc:p11055]	MYH3		Measured	9035	7279.6	1755.4
	neurogenic differentiation factor 2 (neurod2). [swissprot;acc:q15784]	NEUROD2		Ranked	312	284	28
	transcription factor lbx1. [swissprot;acc:p52954]	LBX1	Divided		249.663	298.263	1.19466
158	breast cancer antiestrogen resistance 3. [refseq;acc:nm_003567]	BCAR3		Rooted	56.3507	66.1252	1.17346
	chromodomain helicase-dna-binding protein 3 (chd-3) (mi-2 autoantigen 240 kda protein) (mi2-alpha). [swissprot;acc:q12873]	CHD3	Subtracted	Ranked	312	284	28
	goodpasture antigen-binding protein (ec 2.7.1.37) (gpbp) (collagen type iv alpha 3 binding protein) (star-related lipid transfer protein 11) (stard11) (start domain-containing protein 11). [swissprot;acc:q9y5p4]	COL4A3BP		Squared	76360.8	58841.7	17519.1
	melanoma-associated antigen 6 (mage-6 antigen) (mage3b). [swissprot;acc:p43360]	MAGEA6	Divided	Measured	23693.7	18263	1.29736
	mosaic protein lgn. [swissprot;acc:p81274]	GPSM2		Ranked	249.663	298.263	1.19466
	myosin heavy chain, skeletal muscle, adult 1 (myosin heavy chain iix/d) (myhc-iix/d). [swissprot;acc:p12882]	MYH1	Subtracted	Measured	9035	7279.6	1755.4
	protein phosphatase 1, regulatory subunit 7; sds22. [refseq;acc:nm_002712]	PPP1R7		Rooted	149.397	136.972	12.425
	septin 7 (cdc10 protein homolog). [swissprot;acc:q16181]	SEPT7	Divided	Squared	89182.8	125229	1.40418
159	doc-1 related protein (doc-1r). [swissprot;acc:o75956]	CDK2AP2	Subtracted	Ranked	312	284	28
	huntingtin interacting protein 1 related (hip1-related) (hip 12). [swissprot;acc:o75146]	HIP1R		Squared	76296.4	58801.6	17494.8
	myosin heavy chain, cardiac muscle beta isoform (myhc-beta). [swissprot;acc:p12883]	no value		Measured	9035	7279.6	1755.4
	necdin. [swissprot;acc:q99608]	NDN	Divided		23693.7	18263	1.29736
	regulator of g-protein signaling 17 (rgs17). [swissprot;acc:q9ugc6]	RGS17		Ranked	249.663	298.263	1.19466
	rna-binding protein. [refseq;acc:nm_019027]	no value		Rooted	52.7642	61.9019	1.17318
	septin 6. [swissprot;acc:q14141]	SEPT6		Squared	88953.6	124854	1.40359
	ubiquitin activating enzyme e1-like protein. [refseq;acc:nm_006395]	no value	Subtracted	Rooted	113.983	101.979	12.004
160	apobec-1 complementation factor isoform 1; apobec-1 stimulating protein; apo-b rna editing protein. [refseq;acc:nm_014576]		Divided		52.7642	61.9019	1.17318
	dj756n5.1.1 (continues in em:al133324 as dj1161h23.3) (fragment). [sptrembl;acc:q9h430]	MYH7B	Subtracted	Measured	9035	7279.6	1755.4
	guanine nucleotide-binding protein g(o), alpha subunit 1. [swissprot;acc:p09471]	GNAO1	Divided	Ranked	249.663	298.263	1.19466
	homeobox protein hox-c4 (hox-3e) (cp19). [swissprot;acc:p09017]	no value		Squared	173408	242989	1.40126
	kv channel interacting protein 1; vesicle apc-binding protein; a-type potassium channel modulatory protein 1. [refseq;acc:nm_014592]	KCNIP1	Subtracted	Rooted	43.4291	31.7159	11.7132
	melanoma-associated antigen d1 (mage-d1 antigen) (neurotrophin receptor-interacting mage homolog) (pro2292). [swissprot;acc:q9y5v3]	MAGED1	Divided	Measured	23693.7	18263	1.29736
	neurogenic differentiation factor 6 (neurod6) (my051 protein). [swissprot;acc:q96nk8]	NEUROD6	Subtracted	Ranked	312	284	28
	t-complex protein 1, gamma subunit (tcp-1-gamma) (cct-gamma). [swissprot;acc:p49368]	CCT3		Squared	42788.3	60162.6	17374.3
161	homeobox protein hox-b4 (hox-2f) (hox-2.6). [swissprot;acc:p17483]	HOXB4	Divided		173408	242989	1.40126
	melanoma-associated antigen f1 (mage-f1 antigen). [swissprot;acc:q9hay2]	MAGEF1		Measured	23693.7	18263	1.29736
	myosin heavy chain, skeletal muscle, extraocular (myhc-eo). [swissprot;acc:q9ukx3]	MYH13	Subtracted		9035	7279.6	1755.4
	neurogenic differentiation factor 1 (neurod1) (neurod). [swissprot;acc:q13562]	NEUROD1		Ranked	312	284	28
	ns1-associated protein 1. [refseq;acc:nm_006372]	SYNCRIP	Divided	Rooted	52.7642	61.9019	1.17318
	potassium channel-interacting protein 4 isoform 4; calsenilin-like protein. [refseq;acc:nm_147183]	KCNIP4	Subtracted		43.4519	31.7522	11.6997
	rap1 gtpase-activating protein 1 (rap1gap). [swissprot;acc:p47736]	RAP1GAP	Divided	Ranked	249.663	298.263	1.19466
	trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase (ec 2.1.1.61). [swissprot;acc:o75648]	TRMU	Subtracted	Squared	52591.3	69845.1	17253.8
162	atlastin; guanylate-binding protein 3. [refseq;acc:nm_015915]	no value		Ranked	142	170	28
	heterogeneous nuclear ribonucleoprotein r (hnrnp r). [swissprot;acc:o43390]	HNRNPR	Divided	Rooted	52.7642	61.9019	1.17318
	high-mobility group 20a. [refseq;acc:nm_018200]	HMG20A	Subtracted	Measured	5140.14	6893.53	1753.39
	homeobox protein hox-c5 (hox-3d) (cp11). [swissprot;acc:q00444]	HOXC5	Divided	Squared	173408	242989	1.40126
	kv channel interacting protein 2 isoform 4; a-type potassium channel modulatory protein 2; cardiac voltage gated potassium channel modulatory subunit. [refseq;acc:nm_173193]	KCNIP2	Subtracted	Rooted	43.4554	31.7576	11.6978
	melanoma antigen, family b, 6. [refseq;acc:nm_173523]	MAGEB6B	Divided	Measured	23693.7	18263	1.29736
	nostrin. [refseq;acc:nm_052946]	NOSTRIN		Ranked	209.299	249.187	1.19058
	stem cell growth factor; lymphocyte secreted c-type lectin; lymphocyte secreted c-type lectin. [refseq;acc:nm_002975]	CLEC11A	Subtracted	Squared	59704	76460.4	16756.4
163	20 kda nuclear cap binding protein (ncbp 20 kda subunit) (cbp20) (ncbp interacting protein 1) (nip1). [swissprot;acc:p52298]	NCBP2		Rooted	54.935	66.6101	11.6751
	beta-arrestin 2 (arrestin, beta 2). [swissprot;acc:p32121]	ARRB2		Ranked	133	105	28
	c-type lectin superfamily member 1 precursor (cartilage-derived c-type lectin). [swissprot;acc:o75596]	CLEC3A		Squared	59464	76120.8	16656.8
	eap30 subunit of ell complex. [refseq;acc:nm_007241]	SNF8	Divided	Ranked	209.299	249.187	1.19058

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.