MK5 Microarray Data

These are the micro-array results of a differential gene expression microarray experiments and the subsequent analysis steps performed on them. The up/down- regulation ratio was obtained by measuring WT cells against MK5 activated cells. See material and methods for technical information as well as the data usage policy.

Proteome Analysis

Below the proteome analysis is presented. The analysis methods are presented in the paper Propagating Differential Gene Expression in Protein Interaction Networks. If you are interested in the most reliable results choose the

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description	Rank	Gene	Hugo	Network Comparison Type	Value Type	Interaction Map	Filtered	red	green	network_comparison

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Showing element 1251 to 1300 of 8289 in total

Network Comparison Type  : Divided
Value Type  : Ranked
Filtered  : 1

description	Rank	Hugo	Interaction Map	red	green	network_comparison
carboxypeptidase n 83 kda chain (carboxypeptidase n regulatory subunit) (fragment). [swissprot;acc:p22792]	4834	CPN2	Low confidence	184.376	183.711	1.00362
carboxypeptidase n catalytic chain precursor (ec 3.4.17.3) (arginine carboxypeptidase) (kininase 1) (serum carboxypeptidase n) (scpn) (anaphylatoxin inactivator) (plasma carboxypeptidase b). [swissprot;acc:p15169]	715	CPN1	High confidence	223.121	211.685	1.05402
	3432		Low confidence	201.289	198.276	1.0152
carcinoma related gene. [refseq;acc:nm_016041]	3179	DERL2	High confidence	0.00001	0.00001	1
	5058		Low confidence
carnitine o-acetyltransferase (ec 2.3.1.7) (carnitine acetylase) (cat). [swissprot;acc:p43155]	1698	CRAT	High confidence	217.624	214.69	1.01367
	4463		Low confidence	202.986	201.152	1.00912
carnitine o-palmitoyltransferase i, mitochondrial liver isoform (ec 2.3.1.21) (cpt i) (cpti-l). [swissprot;acc:p50416]	1099	CPT1A		203.519	198.789	1.02379
carnitine o-palmitoyltransferase i, mitochondrial muscle isoform (ec 2.3.1.21) (cpt i) (cpti-m) (carnitine palmitoyltransferase i like protein). [swissprot;acc:q92523]	1631	CHKB		199.793	195.725	1.02078
carnitine o-palmitoyltransferase ii, mitochondrial precursor (ec 2.3.1.21) (cpt ii). [swissprot;acc:p23786]	2885	CPT2	High confidence	0.00001	0.00001	1
	3335		Low confidence	196.512	193.497	1.01558
carnitine palmitoyltransferase i related c. [refseq;acc:nm_152359]	1091	CPT1C		203.519	198.789	1.02379
cartilage oligomeric matrix protein precursor (comp). [swissprot;acc:p49747]	226	COMP	High confidence	239.991	269.238	1.12187
	4745		Low confidence	213.766	214.907	1.00534
casein kinase i alpha s-like. [refseq;acc:nm_145203]	1495	CSNK1A1L	High confidence	229.459	225.237	1.01874
	3590		Low confidence	199.578	196.734	1.01446
casein kinase i, alpha isoform (ec 2.7.1.-) (cki-alpha) (ck1). [swissprot;acc:p48729]	1496	CSNK1A1	High confidence	229.459	225.237	1.01874
	3591		Low confidence	199.578	196.734	1.01446
casein kinase i, delta isoform (ec 2.7.1.-) (cki-delta) (ckid). [swissprot;acc:p48730]	1721	CSNK1D	High confidence	227.125	224.164	1.01321
	3521		Low confidence	199.471	196.561	1.0148
casein kinase i, epsilon isoform (ec 2.7.1.-) (cki-epsilon) (ckie). [swissprot;acc:p49674]	1710	no value	High confidence	227.225	224.21	1.01345
	3527		Low confidence	199.463	196.557	1.01478
casein kinase i, gamma 1 isoform (ec 2.7.1.-) (cki-gamma 1). [swissprot;acc:q9hcp0]	2830	CSNK1G1	High confidence	0.00001	0.00001	1
	4010		Low confidence	196.478	194.223	1.01161
casein kinase i, gamma 2 isoform (ec 2.7.1.-) (cki-gamma 2). [swissprot;acc:p78368]	2986	CSNK1G2	High confidence	0.00001	0.00001	1
	4017		Low confidence	196.498	194.246	1.01159
casein kinase i, gamma 3 isoform (ec 2.7.1.-) (cki-gamma 3). [swissprot;acc:q9y6m4]	2901	CSNK1G3	High confidence	0.00001	0.00001	1
	4013		Low confidence	196.51	194.256	1.0116
casein kinase ii beta chain (ck ii) (phosvitin) (g5a). [swissprot;acc:p13862]	936	no value	High confidence	232.473	224.372	1.03611
	1283		Low confidence	205.134	200.628	1.02246
casein kinase ii, alpha chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19138]	863	CSNK2A1P	High confidence	240.194	230.957	1.03999
	1396		Low confidence	203.987	199.614	1.02191
casein kinase ii, alpha' chain (ck ii) (ec 2.7.1.37). [swissprot;acc:p19784]	864	CSNK2A2	High confidence	240.194	230.957	1.03999
	1344		Low confidence	204.058	199.639	1.02213
caspase-7 precursor (ec 3.4.22.-) (ice-like apoptotic protease 3) (ice-lap3) (apoptotic protease mch-3) (cmh-1). [swissprot;acc:p55210]	1292	CASP7	High confidence	233.942	228.46	1.024
	3278		Low confidence	200.06	196.969	1.01569
caspr5 protein isoform 1. [refseq;acc:nm_130773]	2096	CNTNAP5		208.784	204.84	1.01925
catalase (ec 1.11.1.6). [swissprot;acc:p04040]	3162	CAT		200.833	197.631	1.0162
catenin (cadherin-associated protein), alpha-like 1; alpha-catulin. [refseq;acc:nm_003798]	1834	CTNNAL1	High confidence	180.409	182.459	1.01136
	2169		Low confidence	199.004	195.281	1.01906
cathepsin b precursor (ec 3.4.22.1) (cathepsin b1) (app secretase). [swissprot;acc:p07858]	826	CTSB		201.026	195.916	1.02608
	1667		High confidence	214.898	211.898	1.01416
cathepsin d precursor (ec 3.4.23.5). [swissprot;acc:p07339]	1653	CTSD	Low confidence	200.398	196.334	1.0207
cathepsin f precursor (ec 3.4.22.41) (catsf). [swissprot;acc:q9ubx1]	3383	CTSF		197.398	194.412	1.01536
cathepsin l precursor (ec 3.4.22.15) (major excreted protein) (mep). [swissprot;acc:p07711]	156	CTSL1		211.808	199.761	1.06031
	1426		High confidence	214.717	219.157	1.02068
cathepsin l2 precursor (ec 3.4.22.43) (cathepsin v) (cathepsin u). [swissprot;acc:o60911]	155	CTSL2	Low confidence	211.818	199.734	1.0605
	1425		High confidence	214.717	219.157	1.02068
cathepsin z precursor (ec 3.4.22.-) (cathepsin x) (cathepsin p). [swissprot;acc:q9ubr2]	151	CTSZ	Low confidence	206.516	194.554	1.06148
cationic amino acid transporter-4 (cat-4) (cat4). [swissprot;acc:o43246]	1059	SLC7A4		200.552	195.852	1.024

Legend:
- Rank is the rank after comparing the two networks
- Gene is the ensembl human gene identifier measured by 1 or more probes on the microarray
- Hugo is the HGNC identifier if it exists
- Value Type describes how the microarray measurement was processed. Ranked indicates that we sorted all measurements and use the rank as red and green value. Measured is the normal measurement. Squared and Rooted are the square and square root respecitcely. This might be valueable to compensate for non linear light distributions.
- Network Comparison Type describes whether we divided the red and green types or whether we sutractcted them
- Interaction Map specifies whether we used only the hig hconfidence protein-protein interactions or also included the low confidence interactions.
- Filtered specifies whether we only included the high confidence microarry measurements or not.